Literature DB >> 20117930

Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.

John E Coughlin1, Seetharamaiyer Padmanabhan, Guangrong Zhang, Cassandra J Kirk, Chandrika P Govardhan, Brent E Korba, Kathleen O'Loughlin, Carol E Green, Jon Mirsalis, John D Morrey, Radhakrishnan P Iyer.   

Abstract

The acyloxyalkyl derivatives of a model anti-HBV dinucleotide were synthesized and evaluated as orally bioavailable prodrugs. Our studies have led to the identification of the first orally bioavailable dinucleotide prodrugs for further therapeutic development against the hepatitis B virus (HBV). Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20117930      PMCID： PMC2826611          DOI： 10.1016/j.bmcl.2010.01.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Anti-HBV nucleotide prodrug analogs: synthesis, bioreversibility, and cytotoxicity studies.

Authors:  Seetharamaiyer Padmanabhan; John E Coughlin; Guangrong Zhang; Cassandra J Kirk; Radhakrishnan P Iyer
Journal:  Bioorg Med Chem Lett       Date:  2006-01-04       Impact factor: 2.823

2.  RAPID FUNCTIONALIZATION AND LOADING OF SOLID SUPPORTS.

Authors:  Radhakrishnan P Iyer; John E Coughlin; Seetharamaiyer Padmanabhan
Journal:  Org Prep Proced Int       Date:  2005-06       Impact factor: 1.628

Review 3.  Nucleotide analogs as novel anti-hepatitis B virus agents.

Authors:  Radhakrishnan P Iyer; Seetharamaiyer Padmanabhan; Guangrong Zhang; John D Morrey; Brent E Korba
Journal:  Curr Opin Pharmacol       Date:  2005-10       Impact factor: 5.547

4.  Bioorganic chemistry of phosphorus.

Authors:  R Singleton
Journal:  J Chem Educ       Date:  1973-08       Impact factor: 2.979

5.  Transport of L-valine-acyclovir via the oligopeptide transporter in the human intestinal cell line, Caco-2.

Authors:  R L de Vrueh; P L Smith; C P Lee
Journal:  J Pharmacol Exp Ther       Date:  1998-09       Impact factor: 4.030

6.  New bis(SATE) prodrug of AZT 5'-monophosphate: in vitro anti-HIV activity, stability, and potential oral absorption.

Authors:  M Shafiee; S Deferme; A L Villard; D Egron; G Gosselin; J L Imbach; T Lioux; A Pompon; S Varray; A M Aubertin; G Van Den Mooter; R Kinget; C Périgaud; P Augustijns
Journal:  J Pharm Sci       Date:  2001-04       Impact factor: 3.534

Review 7.  Overview of treatment of hepatitis B: key approaches and clinical challenges.

Authors:  Robert P Perrillo
Journal:  Semin Liver Dis       Date:  2004       Impact factor: 6.115

Review 8.  Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures.

Authors:  D Lavanchy
Journal:  J Viral Hepat       Date:  2004-03       Impact factor: 3.728

9.  Phosphorothioate di- and trinucleotides as a novel class of anti-hepatitis B virus agents.

Authors:  Radhakrishnan P Iyer; Yi Jin; Arlene Roland; John D Morrey; Samir Mounir; Brent Korba
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191

10.  Anti-hepatitis B virus activity of ORI-9020, a novel phosphorothioate dinucleotide, in a transgenic mouse model.

Authors:  Radhakrishnan P Iyer; Arlene Roland; Yi Jin; Samir Mounir; Brent Korba; Justin G Julander; John D Morrey
Journal:  Antimicrob Agents Chemother       Date:  2004-06       Impact factor: 5.191
  10 in total
  3 in total

1.  Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate.

Authors:  John E Coughlin; Rajendra K Pandey; Seetharamaiyer Padmanabhan; Kathleen G O'Loughlin; Judith Marquis; Carol E Green; Jon C Mirsalis; Radhakrishnan P Iyer
Journal:  Drug Metab Dispos       Date:  2012-02-10       Impact factor: 3.922

2.  Antiviral Efficacy and Host Innate Immunity Associated with SB 9200 Treatment in the Woodchuck Model of Chronic Hepatitis B.

Authors:  Kyle E Korolowicz; Radhakrishnan P Iyer; Stefanie Czerwinski; Manasa Suresh; Junming Yang; Seetharamaiyer Padmanabhan; Anjaneyulu Sheri; Rajendra K Pandey; Jeffrey Skell; Judith K Marquis; Bhaskar V Kallakury; Robin D Tucker; Stephan Menne
Journal:  PLoS One       Date:  2016-08-23       Impact factor: 3.240

Review 3.  Recent Drug Development in the Woodchuck Model of Chronic Hepatitis B.

Authors:  Manasa Suresh; Stephan Menne
Journal:  Viruses       Date:  2022-08-03       Impact factor: 5.818
  3 in total

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