Literature DB >> 16387496

Anti-HBV nucleotide prodrug analogs: synthesis, bioreversibility, and cytotoxicity studies.

Seetharamaiyer Padmanabhan1, John E Coughlin, Guangrong Zhang, Cassandra J Kirk, Radhakrishnan P Iyer.   

Abstract

Several pronucleotide analogs of the model anti-HBV dinucleotide 3'-dA-U(2'OMe) have been synthesized and evaluated for stability, bioreversibility and cytotoxicity. These studies have helped identify potential candidates for further evaluation.

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Year:  2006        PMID： 16387496     DOI： 10.1016/j.bmcl.2005.12.058

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  Orally bioavailable anti-HBV dinucleotide acyloxyalkyl prodrugs.

Authors:  John E Coughlin; Seetharamaiyer Padmanabhan; Guangrong Zhang; Cassandra J Kirk; Chandrika P Govardhan; Brent E Korba; Kathleen O'Loughlin; Carol E Green; Jon Mirsalis; John D Morrey; Radhakrishnan P Iyer
Journal:  Bioorg Med Chem Lett       Date:  2010-01-11       Impact factor: 2.823

2.  Site-specific labeling of DNA and RNA using an efficiently replicated and transcribed class of unnatural base pairs.

Authors:  Young Jun Seo; Denis A Malyshev; Thomas Lavergne; Phillip Ordoukhanian; Floyd E Romesberg
Journal:  J Am Chem Soc       Date:  2011-11-18       Impact factor: 15.419

3.  Metabolism, pharmacokinetics, tissue distribution, and stability studies of the prodrug analog of an anti-hepatitis B virus dinucleoside phosphorothioate.

Authors:  John E Coughlin; Rajendra K Pandey; Seetharamaiyer Padmanabhan; Kathleen G O'Loughlin; Judith Marquis; Carol E Green; Jon C Mirsalis; Radhakrishnan P Iyer
Journal:  Drug Metab Dispos       Date:  2012-02-10       Impact factor: 3.922

4.  3-Acetyloxy-2-cyano-2-(alkylaminocarbamoyl)propyl groups as biodegradable protecting groups of nucleoside 5´-mono-phosphates.

Authors:  Mikko Ora; Anne Mäntyvaara; Harri Lönnberg
Journal:  Molecules       Date:  2011-01-14       Impact factor: 4.411
  4 in total

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