Literature DB >> 20116908

Synthesis and in vitro activity of limonene derivatives against Leishmania and Trypanosoma.

Cedric S Graebin1, Maria de F Madeira, Jenicer K U Yokoyama-Yasunaka, Danilo C Miguel, Silvia R B Uliana, Diego Benitez, Hugo Cerecetto, Mercedes González, Ricardo Gomes da Rosa, Vera Lucia Eifler-Lima.   

Abstract

The synthesis and in vitro activity of R(+)-Limonene derivatives against Leishmania and Trypanosoma cruzi strains are reported. Seven compounds have shown better in vitro activity against Leishmania (V.)braziliensis than the standard drug pentamidine. Additionally, we have identified two promising new anti-T. cruzi limonene derivatives. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20116908     DOI： 10.1016/j.ejmech.2009.12.061

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  5 in total

1.  Anthelmintic activity of Eucalyptus staigeriana encapsulated oil on sheep gastrointestinal nematodes.

Authors:  Mayara de Aquino Mesquita; João Batista E Silva Júnior; Andressa Machado Panassol; Erick Falcão de Oliveira; Ana Lourdes Camurça Fernandes Vasconcelos; Haroldo Cesar Beserra de Paula; Claudia Maria Leal Bevilaqua
Journal:  Parasitol Res       Date:  2013-06-20       Impact factor: 2.289

2.  Benzaldehyde thiosemicarbazone derived from limonene complexed with copper induced mitochondrial dysfunction in Leishmania amazonensis.

Authors:  Elizandra Aparecida Britta; Ana Paula Barbosa Silva; Tânia Ueda-Nakamura; Benedito Prado Dias-Filho; Cleuza Conceição Silva; Rosana Lázara Sernaglia; Celso Vataru Nakamura
Journal:  PLoS One       Date:  2012-08-01       Impact factor: 3.240

3.  Cell death and ultrastructural alterations in Leishmania amazonensis caused by new compound 4-Nitrobenzaldehyde thiosemicarbazone derived from S-limonene.

Authors:  Elizandra Aparecida Britta; Débora Botura Scariot; Hugo Falzirolli; Tânia Ueda-Nakamura; Cleuza Conceição Silva; Benedito Prado Dias Filho; Redouane Borsali; Celso Vataru Nakamura
Journal:  BMC Microbiol       Date:  2014-09-26       Impact factor: 3.605

4.  Effect of Chilled Storage on Antioxidant Capacities and Volatile Flavors of Synbiotic Yogurt Made with Probiotic Yeast Saccharomyces boulardii CNCM I-745 in Combination with Inulin.

Authors:  Abid Sarwar; Sam Al-Dalali; Tariq Aziz; Zhennai Yang; Jalal Ud Din; Ayaz Ali Khan; Zubaida Daudzai; Quratulain Syed; Rubina Nelofer; Nazif Ullah Qazi; Zhang Jian; Anas S Dablool
Journal:  J Fungi (Basel)       Date:  2022-07-06

Review 5.  Synthetic Medicinal Chemistry in Chagas' Disease: Compounds at The Final Stage of "Hit-To-Lead" Phase.

Authors:  Hugo Cerecetto; Mercedes González
Journal:  Pharmaceuticals (Basel)       Date:  2010-03-25
  5 in total

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