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Literature DB >> 20116089

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.

Akiko Kumagai¹, Anna Shevchenko, Andrej Shevchenko, William G Dunphy.

Abstract

TopBP1 has important roles in both DNA replication and checkpoint regulation in vertebrates. We have identified a protein called Treslin that associates with TopBP1 in Xenopus egg extracts. Depletion of Treslin from egg extracts strongly inhibits chromosomal DNA replication. Binding of Treslin to chromatin in egg extracts occurs independently of TopBP1. However, loading of the initiator protein Cdc45 onto chromatin cannot take place in the absence of Treslin. Prior to the initiation of DNA replication, Treslin associates with TopBP1 in a Cdk2-dependent manner. Ablation of Treslin from human cells also strongly inhibits DNA replication. Taken together, these results indicate that Treslin and TopBP1 collaborate in the Cdk2-mediated loading of Cdc45 onto replication origins. Thus, Treslin regulates a pivotal step in the initiation of DNA replication in vertebrates. 2010 Elsevier Inc. All rights reserved.

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Year: 2010 PMID： 20116089 PMCID： PMC2857569 DOI： 10.1016/j.cell.2009.12.049

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

34 in total

Review 1. Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins.

Authors: Juan Méndez; Bruce Stillman
Journal: Bioessays Date: 2003-12 Impact factor: 4.345

2. The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication.

Authors: Kumiko Matsuno; Maya Kumano; Yumiko Kubota; Yoshitami Hashimoto; Haruhiko Takisawa
Journal: Mol Cell Biol Date: 2006-07 Impact factor: 4.272

3. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

Authors: Philip Zegerman; John F X Diffley
Journal: Nature Date: 2006-12-13 Impact factor: 49.962

4. Cell biology: a switch for S phase.

Authors: Michael Botchan
Journal: Nature Date: 2007-01-18 Impact factor: 49.962

5. In-gel digestion for mass spectrometric characterization of proteins and proteomes.

Authors: Andrej Shevchenko; Henrik Tomas; Jan Havlis; Jesper V Olsen; Matthias Mann
Journal: Nat Protoc Date: 2006 Impact factor: 13.491

6. TopBP1 activates the ATR-ATRIP complex.

Authors: Akiko Kumagai; Joon Lee; Hae Yong Yoo; William G Dunphy
Journal: Cell Date: 2006-03-10 Impact factor: 41.582

7. Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification.

Authors: Magno Junqueira; Victor Spirin; Tiago Santana Balbuena; Patrice Waridel; Vineeth Surendranath; Grigoriy Kryukov; Ivan Adzhubei; Henrik Thomas; Shamil Sunyaev; Andrej Shevchenko
Journal: J Proteome Res Date: 2008-06-18 Impact factor: 4.466

8. The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.

Authors: Yoshitami Hashimoto; Tsuyoshi Tsujimura; Akio Sugino; Haruhiko Takisawa
Journal: Genes Cells Date: 2006-09 Impact factor: 1.891

9. Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.

Authors: David G Monroe; Barbara J Getz; Steven A Johnsen; B Lawrence Riggs; Sundeep Khosla; Thomas C Spelsberg
Journal: J Cell Biochem Date: 2003-10-01 Impact factor: 4.429

10. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

Authors: Daniel A Mordes; Gloria G Glick; Runxiang Zhao; David Cortez
Journal: Genes Dev Date: 2008-06-01 Impact factor: 11.361

122 in total

1. TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

Authors: Kang Liu; Shiyun Ling; Weei-Chin Lin
Journal: Mol Cell Biol Date: 2011-09-19 Impact factor: 4.272

2. Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.

Authors: Young-Hoon Kang; Wiebke Chemnitz Galal; Andrea Farina; Inger Tappin; Jerard Hurwitz
Journal: Proc Natl Acad Sci U S A Date: 2012-04-02 Impact factor: 11.205

Treslin collaborates with TopBP1 in triggering the initiation of DNA replication.

Review 1. Perpetuating the double helix: molecular machines at eukaryotic DNA replication origins.

2. The N-terminal noncatalytic region of Xenopus RecQ4 is required for chromatin binding of DNA polymerase alpha in the initiation of DNA replication.

3. Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

4. Cell biology: a switch for S phase.

5. In-gel digestion for mass spectrometric characterization of proteins and proteomes.

6. TopBP1 activates the ATR-ATRIP complex.

7. Separating the wheat from the chaff: unbiased filtering of background tandem mass spectra improves protein identification.

8. The phosphorylated C-terminal domain of Xenopus Cut5 directly mediates ATR-dependent activation of Chk1.

9. Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta.

10. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain.

1. TopBP1 mediates mutant p53 gain of function through NF-Y and p63/p73.

2. Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its action with DNA polymerase epsilon in rolling circle DNA synthesis.

3. Role for Rif1 in the checkpoint response to damaged DNA in Xenopus egg extracts.

4. GEMC1 is a novel TopBP1-interacting protein involved in chromosomal DNA replication.

Review 5. Regulation of the initiation step of DNA replication by cyclin-dependent kinases.

Review 6. How do Cdc7 and cyclin-dependent kinases trigger the initiation of chromosome replication in eukaryotic cells?

7. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control.

Review 8. Eukaryotic DNA replication origins: many choices for appropriate answers.

9. TopBP1 functions with 53BP1 in the G1 DNA damage checkpoint.

10. Mutant p53 perturbs DNA replication checkpoint control through TopBP1 and Treslin.