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Literature DB >> 2011535

RecA-dependent incision of psoralen-crosslinked DNA by (A)BC excinuclease.

Abstract

Previous work to elucidate the mechanism of crosslink repair by (A)BC excinuclease has shown that a psoralen-crosslinked duplex is selectively incised in the furan-side strand, while a three-stranded structure is incised in the pyrone-side strand of the crosslink. These observations support a sequential incision and recombination model for the complete error-free repair of a psoralen crosslink. The work presented here extends these findings by demonstrating that in the presence of RecA protein and a homologous DNA oligonucleotide, (A)BC excinuclease is induced to incise the pyrone-side strand of a crosslinked double-stranded plasmid molecule. This finding adds further support to the current model for error-free crosslink repair.

Entities: Chemical Disease Gene

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Year: 1991 PMID： 2011535 PMCID： PMC333662 DOI： 10.1093/nar/19.3.657

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

20 in total

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Authors: T Kodadek; H Gamper
Journal: Biochemistry Date: 1988-05-03 Impact factor: 3.162

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Authors: M T Tomic; D E Wemmer; S H Kim
Journal: Science Date: 1987-12-18 Impact factor: 47.728

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26 in total

1. DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts.

Authors: D Mu; T Bessho; L V Nechev; D J Chen; T M Harris; J E Hearst; A Sancar
Journal: Mol Cell Biol Date: 2000-04 Impact factor: 4.272

2. DNA crosslinking damage and cancer - a tale of friend and foe.

Authors: Yaling Huang; Lei Li
Journal: Transl Cancer Res Date: 2013-06 Impact factor: 1.241

3. The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.

Authors: Katsuhiro Hanada; Magda Budzowska; Mauro Modesti; Alex Maas; Claire Wyman; Jeroen Essers; Roland Kanaar
Journal: EMBO J Date: 2006-10-12 Impact factor: 11.598

RecA-dependent incision of psoralen-crosslinked DNA by (A)BC excinuclease.

1. Amplification and purification of UvrA, UvrB, and UvrC proteins of Escherichia coli.

2. Construction of DNA substrates modified with psoralen at a unique site and study of the action mechanism of ABC excinuclease on these uniformly modified substrates.

Review 3. DNA repair.

4. Efficient synthesis of a supercoiled M13 DNA molecule containing a site specifically placed psoralen adduct and its use as a substrate for DNA replication.

5. Structure of a psoralen cross-linked DNA in solution by nuclear magnetic resonance.

6. Action mechanism of ABC excision nuclease on a DNA substrate containing a psoralen crosslink at a defined position.

7. Purification of Escherichia coli DNA photolyase.

8. Specific strand loss in N-2-acetylaminofluorene-modified DNA.

9. Repair of DNA containing interstrand crosslinks in Escherichia coli: sequential excision and recombination.

10. Postreplication repair in E. coli: strand exchange reactions of gapped DNA by RecA protein.

1. DNA interstrand cross-links induce futile repair synthesis in mammalian cell extracts.

2. DNA crosslinking damage and cancer - a tale of friend and foe.

3. The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaks.

Review 4. Formation and repair of interstrand cross-links in DNA.

5. A specific 3' exonuclease activity of UvrABC.

6. Recombination induced by triple-helix-targeted DNA damage in mammalian cells.

7. Repair of intermediate structures produced at DNA interstrand cross-links in Saccharomyces cerevisiae.

8. Methods for the large-scale synthesis of psoralen furan-side monoadducts and diadducts.

Review 9. REV1 and DNA polymerase zeta in DNA interstrand crosslink repair.

10. Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks.