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Literature DB >> 20109583

Comparative cellular biogerontology: primer and prospectus.

Richard A Miller¹, Joseph B Williams, J Veronika Kiklevich, Steve Austad, James M Harper.

Abstract

Most prior work on the biological basis of aging has focused on describing differences between young and old individuals but provided only limited insight into the mechanisms controlling the rate of aging. Natural selection has produced a goldmine of experimental material, in the form of species of differing aging rate, whose longevity can vary by 10-fold or more within mammalian orders, but these resources remain largely unexplored at the cellular level. In this review article we focus on one approach to comparative biogerontology: the strategy of evaluating the properties of cultured cells from organisms of varying lifespan and aging rate. In addition, we discuss problems associated with the analysis and interpretations of interspecific variation of cellular trait data among species with disparate longevity. Given the impressive array of 'natural experiments' in aging rate, overcoming the technical and conceptual obstacles confronting research in comparative cellular gerontology will be well worth the effort.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20109583 PMCID： PMC2889236 DOI： 10.1016/j.arr.2010.01.002

Source DB: PubMed Journal: Ageing Res Rev ISSN： 1568-1637 Impact factor: 10.895

93 in total

1. Telomere loss in relation to age and early environment in long-lived birds.

Authors: Margaret E Hall; Lubna Nasir; Francis Daunt; Elizabeth A Gault; John P Croxall; Sarah Wanless; Pat Monaghan
Journal: Proc Biol Sci Date: 2004-08-07 Impact factor: 5.349

Review 2. Body size, energy metabolism and lifespan.

Authors: John R Speakman
Journal: J Exp Biol Date: 2005-05 Impact factor: 3.312

Review 3. Cellular senescence as a tumor-suppressor mechanism.

Authors: J Campisi
Journal: Trends Cell Biol Date: 2001-11 Impact factor: 20.808

4. On the importance of fatty acid composition of membranes for aging.

Authors: A J Hulbert
Journal: J Theor Biol Date: 2005-01-24 Impact factor: 2.691

5. Telomerase expression is differentially regulated in birds of differing life span.

Authors: Mark F Haussmann; David W Winkler; Charles E Huntington; Ian C T Nisbet; Carol M Vleck
Journal: Ann N Y Acad Sci Date: 2004-06 Impact factor: 5.691

6. Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture.

Authors: R N Venkatesan; C Price
Journal: Proc Natl Acad Sci U S A Date: 1998-12-08 Impact factor: 11.205

7. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture.

Authors: Rita A Busuttil; Miguel Rubio; Martijn E T Dollé; Judith Campisi; Jan Vijg
Journal: Aging Cell Date: 2003-12 Impact factor: 9.304

8. Height and body mass index in relation to esophageal cancer; 23-year follow-up of two million Norwegian men and women.

Authors: Anders Engeland; Steinar Tretli; Tone Bjørge
Journal: Cancer Causes Control Date: 2004-10 Impact factor: 2.506

Review 9. RNA-Seq: a revolutionary tool for transcriptomics.

Authors: Zhong Wang; Mark Gerstein; Michael Snyder
Journal: Nat Rev Genet Date: 2009-01 Impact factor: 53.242

10. Correlation of mitochondrial superoxide dismutase and DNA polymerase beta in mammalian dermal fibroblasts with species maximal lifespan.

Authors: Melanie F Brown; Jeffrey A Stuart
Journal: Mech Ageing Dev Date: 2007-10-23 Impact factor: 5.432

8 in total

1. Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity.

Authors: Amir A Sadighi Akha; James M Harper; Adam B Salmon; Bethany A Schroeder; Heather M Tyra; D Thomas Rutkowski; Richard A Miller
Journal: J Biol Chem Date: 2011-07-12 Impact factor: 5.157

Comparative cellular biogerontology: primer and prospectus.

1. Telomere loss in relation to age and early environment in long-lived birds.

Review 2. Body size, energy metabolism and lifespan.

Review 3. Cellular senescence as a tumor-suppressor mechanism.

4. On the importance of fatty acid composition of membranes for aging.

5. Telomerase expression is differentially regulated in birds of differing life span.

6. Telomerase expression in chickens: constitutive activity in somatic tissues and down-regulation in culture.

7. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture.

8. Height and body mass index in relation to esophageal cancer; 23-year follow-up of two million Norwegian men and women.

Review 9. RNA-Seq: a revolutionary tool for transcriptomics.

10. Correlation of mitochondrial superoxide dismutase and DNA polymerase beta in mammalian dermal fibroblasts with species maximal lifespan.

1. Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity.

2. Functional linkages for the pace of life, life-history, and environment in birds.

3. Fibroblasts from long-lived bird species are resistant to multiple forms of stress.

4. Longevity and life history coevolve with oxidative stress in birds.

5. Enhanced protein repair and recycling are not correlated with longevity in 15 vertebrate endotherm species.

6. Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice.

7. Cellular metabolism and oxidative stress as a possible determinant for longevity in small breed and large breed dogs.

8. Report: NIA workshop on translating genetic variants associated with longevity into drug targets.