BACKGROUND: Mucinous and clear cell histology have been associated with adverse prognosis in ovarian carcinomas. The authors compared the outcome of these subtypes with that of serous tumors in patients who were treated with combination paclitaxel/platinum at their center. METHODS: Four hundred twenty patients with histologically confirmed, serous (n = 367), mucinous (n = 24), or clear cell (n = 29) ovarian carcinomas, International Federation of Gynecology and Obstetrics stage III or IV disease, and who were treated with paclitaxel/platinum after cytoreductive surgery were included in this analysis. RESULTS: The median overall survival for each histological subtype was 47.7 months (95% confidence interval [CI], 37.7-57.7 months) for serous, 15.4 months (95% CI, 4.2-26.6 months) for mucinous, and 36.6 months (95% CI, 22.7-50.5 months) for clear cell carcinomas. Cox regression analysis showed that mucinous histology was an independent predictor of poor prognosis compared with serous tumors (hazard ratio, 0.360; 95% CI, 0.215-0.603; P = .001). In contrast, such a difference between clear cell and serous carcinomas was not found (P = .337). Median survival of patients with mucinous tumors and residual disease >2 cm was poor, averaging 7.1 months (95% CI, 4.6-9.6 months). CONCLUSIONS: Mucinous but not clear cell histology is associated with significantly worse prognosis in advanced ovarian cancer treated with combination platinum/paclitaxel. Different therapeutic strategies should be studied in this entity.
BACKGROUND: Mucinous and clear cell histology have been associated with adverse prognosis in ovarian carcinomas. The authors compared the outcome of these subtypes with that of serous tumors in patients who were treated with combination paclitaxel/platinum at their center. METHODS: Four hundred twenty patients with histologically confirmed, serous (n = 367), mucinous (n = 24), or clear cell (n = 29) ovarian carcinomas, International Federation of Gynecology and Obstetrics stage III or IV disease, and who were treated with paclitaxel/platinum after cytoreductive surgery were included in this analysis. RESULTS: The median overall survival for each histological subtype was 47.7 months (95% confidence interval [CI], 37.7-57.7 months) for serous, 15.4 months (95% CI, 4.2-26.6 months) for mucinous, and 36.6 months (95% CI, 22.7-50.5 months) for clear cell carcinomas. Cox regression analysis showed that mucinous histology was an independent predictor of poor prognosis compared with serous tumors (hazard ratio, 0.360; 95% CI, 0.215-0.603; P = .001). In contrast, such a difference between clear cell and serous carcinomas was not found (P = .337). Median survival of patients with mucinous tumors and residual disease >2 cm was poor, averaging 7.1 months (95% CI, 4.6-9.6 months). CONCLUSIONS: Mucinous but not clear cell histology is associated with significantly worse prognosis in advanced ovarian cancer treated with combination platinum/paclitaxel. Different therapeutic strategies should be studied in this entity.
Authors: Koji Matsuo; Masato Nishimura; Justin N Bottsford-Miller; Jie Huang; Kakajan Komurov; Guillermo N Armaiz-Pena; Mian M K Shahzad; Rebecca L Stone; Ju Won Roh; Angela M Sanguino; Chunhua Lu; Dwight D Im; Neil B Rosenshien; Atsuko Sakakibara; Tadayoshi Nagano; Masato Yamasaki; Takayuki Enomoto; Tadashi Kimura; Prahlad T Ram; Kathleen M Schmeler; Gary E Gallick; Kwong K Wong; Michael Frumovitz; Anil K Sood Journal: Clin Cancer Res Date: 2011-07-07 Impact factor: 12.531
Authors: Tao Liu; Wei Hu; Heather J Dalton; Hyun Jin Choi; Jie Huang; Yu Kang; Sunila Pradeep; Takahito Miyake; Jian H Song; Yunfei Wen; Chunhua Lu; Chad V Pecot; Justin Bottsford-Miller; Behrouz Zand; Nicholas B Jennings; Cristina Ivan; Gary E Gallick; Keith A Baggerly; David G Hangauer; Robert L Coleman; Michael Frumovitz; Anil K Sood Journal: Clin Cancer Res Date: 2013-10-07 Impact factor: 12.531
Authors: Takeshi Hisamatsu; Michael McGuire; Sherry Y Wu; Rajesha Rupaimoole; Sunila Pradeep; Emine Bayraktar; Kyunghee Noh; Wei Hu; Jean M Hansen; Yasmin Lyons; Kshipra M Gharpure; Archana S Nagaraja; Lingegowda S Mangala; Takashi Mitamura; Cristian Rodriguez-Aguayo; Young Gyu Eun; Johnathon Rose; Geoffrey Bartholomeusz; Cristina Ivan; Ju-Seog Lee; Koji Matsuo; Michael Frumovitz; Kwong K Wong; Gabriel Lopez-Berestein; Anil K Sood Journal: Mol Cancer Ther Date: 2018-10-10 Impact factor: 6.261
Authors: Kate E Oliver; William E Brady; Michael Birrer; David M Gershenson; Gini Fleming; Larry J Copeland; Krishnansu Tewari; Peter A Argenta; Robert S Mannel; Angeles Alvarez Secord; Jean-Marie Stephan; David G Mutch; Frederick B Stehman; Franco M Muggia; Peter G Rose; Deborah K Armstrong; Michael A Bookman; Robert A Burger; John H Farley Journal: Gynecol Oncol Date: 2017-08-12 Impact factor: 5.482