Literature DB >> 20107641

Coordination complex SH2 domain proteomimetics: an alternative approach to disrupting oncogenic protein-protein interactions.

Joel A Drewry1, Steven Fletcher, Peibin Yue, Denys Marushchak, Wei Zhao, Sumaiya Sharmeen, Xiaolei Zhang, Aaron D Schimmer, Claudiu Gradinaru, James Turkson, Patrick T Gunning.   

Abstract

We report the first application of coordination complexes as functional proteomimetics of the Src homology 2 (SH2) phosphopeptide-binding domain. As a proof-of-concept, functionalized bis-dipicolylamine (BDPA) copper(ii) complexes are shown to disrupt oncogenic Stat3-Stat3 protein complexes and elicit promising anti-tumour activity.

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Year:  2009        PMID： 20107641      PMCID： PMC2910512          DOI： 10.1039/b919608k

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  24 in total

1.  Ion-pairing molecular recognition in water: aggregation at low concentrations that is entropy-driven.

Authors:  Mikhail Rekharsky; Yoshihisa Inoue; Suzanne Tobey; Axel Metzger; Eric Anslyn
Journal:  J Am Chem Soc       Date:  2002-12-18       Impact factor: 15.419

2.  Activation of stat3 in primary tumors from high-risk breast cancer patients is associated with elevated levels of activated SRC and survivin expression.

Authors:  Nills Diaz; Susan Minton; Charles Cox; Tammy Bowman; Tanya Gritsko; Roy Garcia; Ibrahim Eweis; Marek Wloch; Sandy Livingston; Ed Seijo; Alan Cantor; Ji-Hyun Lee; Craig A Beam; Daniel Sullivan; Richard Jove; Carlos A Muro-Cacho
Journal:  Clin Cancer Res       Date:  2006-01-01       Impact factor: 12.531

3.  Effective disruption of phosphoprotein-protein surface interaction using Zn(II) dipicolylamine-based artificial receptors via two-point interaction.

Authors:  Akio Ojida; Masa-aki Inoue; Yasuko Mito-oka; Hiroshi Tsutsumi; Kazuki Sada; Itaru Hamachi
Journal:  J Am Chem Soc       Date:  2006-02-15       Impact factor: 15.419

4.  Stat3 activation by Src induces specific gene regulation and is required for cell transformation.

Authors:  J Turkson; T Bowman; R Garcia; E Caldenhoven; R P De Groot; R Jove
Journal:  Mol Cell Biol       Date:  1998-05       Impact factor: 4.272

5.  Dinuclear lanthanum(III) complex for efficient hydrolysis of RNA.

Authors:  M Yashiro; A Ishikubo; M Komiyama
Journal:  J Biochem       Date:  1996-12       Impact factor: 3.387

6.  Anaplastic lymphoma kinase (ALK) activates Stat3 and protects hematopoietic cells from cell death.

Authors:  Alberto Zamo; Roberto Chiarle; Roberto Piva; Jennifer Howes; Yan Fan; Marco Chilosi; David E Levy; Giorgio Inghirami
Journal:  Oncogene       Date:  2002-02-07       Impact factor: 9.867

7.  Synthesis and binding properties of hybrid cyclophane-azamacrocyclic receptors.

Authors:  Andrew C Benniston; Patrick Gunning; Robert D Peacock
Journal:  J Org Chem       Date:  2005-01-07       Impact factor: 4.354

8.  An oxazole-based small-molecule Stat3 inhibitor modulates Stat3 stability and processing and induces antitumor cell effects.

Authors:  Khandaker A Z Siddiquee; Patrick T Gunning; Matthew Glenn; William P Katt; Shumin Zhang; Christopher Schrock; Christopher Schroeck; Said M Sebti; Richard Jove; Andrew D Hamilton; James Turkson
Journal:  ACS Chem Biol       Date:  2007-12-21       Impact factor: 5.100

9.  Disruption of transcriptionally active Stat3 dimers with non-phosphorylated, salicylic acid-based small molecules: potent in vitro and tumor cell activities.

Authors:  Steven Fletcher; Jagdeep Singh; Xiaolei Zhang; Peibin Yue; Brent D G Page; Sumaiya Sharmeen; Vijay M Shahani; Wei Zhao; Aaron D Schimmer; James Turkson; Patrick T Gunning
Journal:  Chembiochem       Date:  2009-08-17       Impact factor: 3.164

10.  Molecular recognition and fluorescence sensing of monophosphorylated peptides in aqueous solution by bis(zinc(II)-dipicolylamine)-based artificial receptors.

Authors:  Akio Ojida; Yasuko Mito-oka; Kazuki Sada; Itaru Hamachi
Journal:  J Am Chem Soc       Date:  2004-03-03       Impact factor: 15.419
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  6 in total

1.  Applying Small Molecule Signal Transducer and Activator of Transcription-3 (STAT3) Protein Inhibitors as Pancreatic Cancer Therapeutics.

Authors:  Carolyn C Arpin; Stephen Mac; Yanlin Jiang; Huiwen Cheng; Michelle Grimard; Brent D G Page; Malgorzata M Kamocka; Sina Haftchenary; Han Su; Daniel P Ball; David A Rosa; Ping-Shan Lai; Rodolfo F Gómez-Biagi; Ahmed M Ali; Rahul Rana; Helmut Hanenberg; Kagan Kerman; Kyle C McElyea; George E Sandusky; Patrick T Gunning; Melissa L Fishel
Journal:  Mol Cancer Ther       Date:  2016-02-12       Impact factor: 6.261

2.  Antagonizing STAT5B dimerization with an osmium complex.

Authors:  Li-Juan Liu; Wanhe Wang; Tian-Shu Kang; Jia-Xin Liang; Chenfu Liu; Daniel W J Kwong; Vincent Kam Wai Wong; Dik-Lung Ma; Chung-Hang Leung
Journal:  Sci Rep       Date:  2016-11-17       Impact factor: 4.379

3.  Metal complexes as potential modulators of inflammatory and autoimmune responses.

Authors:  Chung-Hang Leung; Sheng Lin; Hai-Jing Zhong; Dik-Lung Ma
Journal:  Chem Sci       Date:  2014-11-07       Impact factor: 9.825

4.  Library synthesis, screening, and discovery of modified Zinc(II)-Bis(dipicolylamine) probe for enhanced molecular imaging of cell death.

Authors:  Adam J Plaunt; Kara M Harmatys; William R Wolter; Mark A Suckow; Bradley D Smith
Journal:  Bioconjug Chem       Date:  2014-03-13       Impact factor: 4.774

5.  Signal transducer and activator of transcription 3 (STAT3) inhibitor, S3I-201, acts as a potent and non-selective alkylating agent.

Authors:  Daniel P Ball; Andrew M Lewis; Declan Williams; Diana Resetca; Derek J Wilson; Patrick T Gunning
Journal:  Oncotarget       Date:  2016-04-12

6.  Direct inhibition of STAT signaling by platinum drugs contributes to their anti-cancer activity.

Authors:  Stanleyson V Hato; Carl G Figdor; Susumu Takahashi; Anja E Pen; Altuna Halilovic; Kalijn F Bol; Angela Vasaturo; Yukie Inoue; Nienke de Haas; Dagmar Verweij; Carla M L Van Herpen; Johannes H Kaanders; Johan H J M van Krieken; Hanneke W M Van Laarhoven; Gerrit K J Hooijer; Cornelis J A Punt; Akira Asai; I Jolanda M de Vries; W Joost Lesterhuis
Journal:  Oncotarget       Date:  2017-05-07
  6 in total

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