Literature DB >> 20103728

Cancer chemoprevention locks onto a new polyamine metabolic target.

Eugene W Gerner1.   

Abstract

Ornithine decarboxylase has a relatively long history as a target for cancer chemoprevention and chemotherapy. Plym Forshell et al. report new evidence (beginning on p. 140 in this issue of the journal) indicating that spermidine synthase, a fellow enzyme of ornithine decarboxylase in polyamine metabolism, is transactivated in part by the MYC gene and is a potential target for chemoprevention of B-cell lymphomas.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20103728      PMCID： PMC3574814          DOI： 10.1158/1940-6207.CAPR-09-0252

Source DB:  PubMed          Journal:  Cancer Prev Res (Phila)        ISSN： 1940-6215


  35 in total

1.  Wild-type APC regulates caveolin-1 expression in human colon adenocarcinoma cell lines via FOXO1a and C-myc.

Authors:  Upal K Basu Roy; Rebecca S Henkhaus; Natalia A Ignatenko; Jessica Mora; Kimberly E Fultz; Eugene W Gerner
Journal:  Mol Carcinog       Date:  2008-12       Impact factor: 4.784

2.  Dietary putrescine reduces the intestinal anticarcinogenic activity of sulindac in a murine model of familial adenomatous polyposis.

Authors:  Natalia A Ignatenko; David G Besselsen; Upal K Basu Roy; David E Stringer; Karen A Blohm-Mangone; Jose L Padilla-Torres; Jose M Guillen-R; Eugene W Gerner
Journal:  Nutr Cancer       Date:  2006       Impact factor: 2.900

Review 3.  Combination chemoprevention for colon cancer targeting polyamine synthesis and inflammation.

Authors:  Eugene W Gerner; Frank L Meyskens
Journal:  Clin Cancer Res       Date:  2009-02-01       Impact factor: 12.531

Review 4.  Rationale for, and design of, a clinical trial targeting polyamine metabolism for colon cancer chemoprevention.

Authors:  E W Gerner; F L Meyskens; S Goldschmid; P Lance; D Pelot
Journal:  Amino Acids       Date:  2007-03-30       Impact factor: 3.520

5.  Activated K-RAS increases polyamine uptake in human colon cancer cells through modulation of caveolar endocytosis.

Authors:  Upal K Basu Roy; Nathaniel S Rial; Karen L Kachel; Eugene W Gerner
Journal:  Mol Carcinog       Date:  2008-07       Impact factor: 4.784

6.  Longitudinal assessment of air conduction audiograms in a phase III clinical trial of difluoromethylornithine and sulindac for prevention of sporadic colorectal adenomas.

Authors:  Christine E McLaren; Sharon Fujikawa-Brooks; Wen-Pin Chen; Daniel L Gillen; Daniel Pelot; Eugene W Gerner; Frank L Meyskens
Journal:  Cancer Prev Res (Phila)       Date:  2008-12

7.  Ornithine decarboxylase G316A genotype is prognostic for colorectal adenoma recurrence and predicts efficacy of aspirin chemoprevention.

Authors:  Richard A Hubner; Kenneth R Muir; Jo-Fen Liu; Richard F A Logan; Matthew J Grainge; Richard S Houlston
Journal:  Clin Cancer Res       Date:  2008-04-15       Impact factor: 12.531

8.  Difluoromethylornithine plus sulindac for the prevention of sporadic colorectal adenomas: a randomized placebo-controlled, double-blind trial.

Authors:  Frank L Meyskens; Christine E McLaren; Daniel Pelot; Sharon Fujikawa-Brooks; Philip M Carpenter; Ernest Hawk; Gary Kelloff; Michael J Lawson; Jayashri Kidao; John McCracken; C Gregory Albers; Dennis J Ahnen; D Kim Turgeon; Steven Goldschmid; Peter Lance; Curt H Hagedorn; Daniel L Gillen; Eugene W Gerner
Journal:  Cancer Prev Res (Phila)       Date:  2008-06

Review 9.  Myc's broad reach.

Authors:  Martin Eilers; Robert N Eisenman
Journal:  Genes Dev       Date:  2008-10-15       Impact factor: 11.361

10.  An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer.

Authors:  Lars Zender; Wen Xue; Johannes Zuber; Camile P Semighini; Alexander Krasnitz; Beicong Ma; Peggy Zender; Stefan Kubicka; John M Luk; Peter Schirmacher; W Richard McCombie; Michael Wigler; James Hicks; Gregory J Hannon; Scott Powers; Scott W Lowe
Journal:  Cell       Date:  2008-11-13       Impact factor: 41.582
View more
  14 in total

1.  Dietary polyamine intake and risk of colorectal adenomatous polyps.

Authors:  Ashley J Vargas; Betsy C Wertheim; Eugene W Gerner; Cynthia A Thomson; Cheryl L Rock; Patricia A Thompson
Journal:  Am J Clin Nutr       Date:  2012-05-30       Impact factor: 7.045

2.  Deoxyhypusine synthase (DHPS) inhibitor GC7 induces p21/Rb-mediated inhibition of tumor cell growth and DHPS expression correlates with poor prognosis in neuroblastoma patients.

Authors:  Andrea Bandino; Dirk Geerts; Jan Koster; André S Bachmann
Journal:  Cell Oncol (Dordr)       Date:  2014-10-15       Impact factor: 6.730

3.  Hydroxydibenzoylmethane induces apoptosis through repressing ornithine decarboxylase in human promyelocytic leukemia HL-60 cells.

Authors:  Ming-Fu Wang; Ya-Fan Liao; Ying-Cheng Hung; Chih-Li Lin; Tzyh-Chyuan Hour; Ko-Huang Lue; Hui-Chih Hung; Guang-Yaw Liu
Journal:  Exp Mol Med       Date:  2011-04-30       Impact factor: 8.718

4.  Dietary polyamine intake and colorectal cancer risk in postmenopausal women.

Authors:  Ashley J Vargas; Erin L Ashbeck; Betsy C Wertheim; Robert B Wallace; Marian L Neuhouser; Cynthia A Thomson; Patricia A Thompson
Journal:  Am J Clin Nutr       Date:  2015-07-01       Impact factor: 7.045

5.  Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase.

Authors:  Indranil Basu; Joseph Locker; Maria B Cassera; Thomas J Belbin; Emilio F Merino; Xinyuan Dong; Ivan Hemeon; Gary B Evans; Chandan Guha; Vern L Schramm
Journal:  J Biol Chem       Date:  2010-12-06       Impact factor: 5.157

6.  Polyamine metabolism is sensitive to glycolysis inhibition in human neuroblastoma cells.

Authors:  M Victoria Ruiz-Pérez; Miguel Ángel Medina; José Luis Urdiales; Tuomo A Keinänen; Francisca Sánchez-Jiménez
Journal:  J Biol Chem       Date:  2015-01-15       Impact factor: 5.157

7.  Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).

Authors:  Seung Bum Lee; Jong Hwan Park; John E Folk; Jason A Deck; Anthony E Pegg; Masaaki Sokabe; Christopher S Fraser; Myung Hee Park
Journal:  Biochem J       Date:  2011-01-01       Impact factor: 3.857

8.  ATP13A3 and caveolin-1 as potential biomarkers for difluoromethylornithine-based therapies in pancreatic cancers.

Authors:  Meenu Madan; Arjun Patel; Kristen Skruber; Dirk Geerts; Deborah A Altomare; Otto Phanstiel Iv
Journal:  Am J Cancer Res       Date:  2016-06-01       Impact factor: 6.166

9.  The Dysregulation of Polyamine Metabolism in Colorectal Cancer Is Associated with Overexpression of c-Myc and C/EBPβ rather than Enterotoxigenic Bacteroides fragilis Infection.

Authors:  Anastasiya V Snezhkina; George S Krasnov; Anastasiya V Lipatova; Asiya F Sadritdinova; Olga L Kardymon; Maria S Fedorova; Nataliya V Melnikova; Oleg A Stepanov; Andrew R Zaretsky; Andrey D Kaprin; Boris Y Alekseev; Alexey A Dmitriev; Anna V Kudryavtseva
Journal:  Oxid Med Cell Longev       Date:  2016-06-28       Impact factor: 6.543

10.  Quantitative metabolomics for investigating the value of polyamines in the early diagnosis and therapy of colorectal cancer.

Authors:  Ran Liu; Xiaohui Lin; Zuojing Li; Qing Li; Kaishun Bi
Journal:  Oncotarget       Date:  2017-12-04
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.