Literature DB >> 20102196

Hyperpolarized 89Y complexes as pH sensitive NMR probes.

Ashish K Jindal1, Matthew E Merritt, Eul Hyun Suh, Craig R Malloy, A Dean Sherry, Zoltán Kovács.   

Abstract

Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.

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Year:  2010        PMID： 20102196      PMCID： PMC2848490          DOI： 10.1021/ja910278e

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  6 in total

1.  In vivo imaging of extracellular pH using 1H MRSI.

Authors:  R van Sluis; Z M Bhujwalla; N Raghunand; P Ballesteros; J Alvarez; S Cerdán; J P Galons; R J Gillies
Journal:  Magn Reson Med       Date:  1999-04       Impact factor: 4.668

2.  Hyperpolarized (89)Y offers the potential of direct imaging of metal ions in biological systems by magnetic resonance.

Authors:  Matthew E Merritt; Crystal Harrison; Zoltan Kovacs; Preeti Kshirsagar; Craig R Malloy; A Dean Sherry
Journal:  J Am Chem Soc       Date:  2007-10-10       Impact factor: 15.419

3.  pH-dependent modulation of relaxivity and luminescence in macrocyclic gadolinium and europium complexes based on reversible intramolecular sulfonamide ligation.

Authors:  M P Lowe; D Parker; O Reany; S Aime; M Botta; G Castellano; E Gianolio; R Pagliarin
Journal:  J Am Chem Soc       Date:  2001-08-08       Impact factor: 15.419

4.  Increase in signal-to-noise ratio of > 10,000 times in liquid-state NMR.

Authors:  Jan H Ardenkjaer-Larsen; Björn Fridlund; Andreas Gram; Georg Hansson; Lennart Hansson; Mathilde H Lerche; Rolf Servin; Mikkel Thaning; Klaes Golman
Journal:  Proc Natl Acad Sci U S A       Date:  2003-08-20       Impact factor: 11.205

5.  Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate.

Authors:  Ferdia A Gallagher; Mikko I Kettunen; Sam E Day; De-En Hu; Jan Henrik Ardenkjaer-Larsen; René in 't Zandt; Pernille R Jensen; Magnus Karlsson; Klaes Golman; Mathilde H Lerche; Kevin M Brindle
Journal:  Nature       Date:  2008-05-28       Impact factor: 49.962

6.  Cancer cell metabolism: Warburg and beyond.

Authors:  Peggy P Hsu; David M Sabatini
Journal:  Cell       Date:  2008-09-05       Impact factor: 41.582
  6 in total
  17 in total

1.  Simultaneous imaging of 13C metabolism and 1H structure: technical considerations and potential applications.

Authors:  Jeremy W Gordon; Sean B Fain; David J Niles; Kai D Ludwig; Kevin M Johnson; Eric T Peterson
Journal:  NMR Biomed       Date:  2015-03-25       Impact factor: 4.044

2.  Hyperpolarized 89Y-EDTMP complex as a chemical shift-based NMR sensor for pH at the physiological range.

Authors:  Qing Wang; Christopher Parish; Peter Niedbalski; James Ratnakar; Zoltan Kovacs; Lloyd Lumata
Journal:  J Magn Reson       Date:  2020-09-29       Impact factor: 2.229

3.  A hydrogen peroxide-responsive hyperpolarized 13C MRI contrast agent.

Authors:  Alexander R Lippert; Kayvan R Keshari; John Kurhanewicz; Christopher J Chang
Journal:  J Am Chem Soc       Date:  2011-03-02       Impact factor: 15.419

4.  DNP by thermal mixing under optimized conditions yields >60,000-fold enhancement of 89Y NMR signal.

Authors:  Lloyd Lumata; Ashish K Jindal; Matthew E Merritt; Craig R Malloy; A Dean Sherry; Zoltan Kovacs
Journal:  J Am Chem Soc       Date:  2011-05-13       Impact factor: 15.419

Review 5.  A review of responsive MRI contrast agents: 2005-2014.

Authors:  Dina V Hingorani; Adam S Bernstein; Mark D Pagel
Journal:  Contrast Media Mol Imaging       Date:  2014-10-29       Impact factor: 3.161

Review 6.  Magnetic resonance imaging with hyperpolarized agents: methods and applications.

Authors:  Erin B Adamson; Kai D Ludwig; David G Mummy; Sean B Fain
Journal:  Phys Med Biol       Date:  2017-04-06       Impact factor: 3.609

7.  The Relationship between NMR Chemical Shifts of Thermally Polarized and Hyperpolarized 89 Y Complexes and Their Solution Structures.

Authors:  Yixun Xing; Ashish K Jindal; Martín Regueiro-Figueroa; Mariane Le Fur; Nelly Kervarec; Piyu Zhao; Zoltan Kovacs; Laura Valencia; Paulo Pérez-Lourido; Raphaël Tripier; David Esteban-Gómez; Carlos Platas-Iglesias; A Dean Sherry
Journal:  Chemistry       Date:  2016-10-10       Impact factor: 5.236

Review 8.  Chemistry and biochemistry of 13C hyperpolarized magnetic resonance using dynamic nuclear polarization.

Authors:  Kayvan R Keshari; David M Wilson
Journal:  Chem Soc Rev       Date:  2013-12-20       Impact factor: 54.564

9.  Hyperpolarized 13C NMR detects rapid drug-induced changes in cardiac metabolism.

Authors:  Chalermchai Khemtong; Nicholas R Carpenter; Lloyd L Lumata; Matthew E Merritt; Karlos X Moreno; Zoltan Kovacs; Craig R Malloy; A Dean Sherry
Journal:  Magn Reson Med       Date:  2014-08-28       Impact factor: 4.668

10.  Impact of Gd3+ on DNP of [1-13C]pyruvate doped with trityl OX063, BDPA, or 4-oxo-TEMPO.

Authors:  Lloyd Lumata; Matthew E Merritt; Craig R Malloy; A Dean Sherry; Zoltan Kovacs
Journal:  J Phys Chem A       Date:  2012-05-18       Impact factor: 2.781
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