Literature DB >> 20101629

Neuronal cholesterol esterification by ACAT1 in Alzheimer's disease.

Ta-Yuan Chang1, Catherine C Y Chang, Elena Bryleva, Maximillian A Rogers, Stephanie R Murphy.   

Abstract

Cholesterol has been implicated in various neurodegenerative diseases. Here we review the connection between cholesterol and Alzheimer's disease (AD), focusing on a recent study that links neuronal cholesterol esterification with biosynthesis of 24(S)-hydroxycholesterol and the fate of human amyloid precursor protein in a mouse model of AD. We also briefly evaluate the potential of ACAT1 as a drug target for AD.

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Year:  2010        PMID： 20101629     DOI： 10.1002/iub.305

Source DB:  PubMed          Journal:  IUBMB Life        ISSN： 1521-6543            Impact factor:   3.885


  6 in total

1.  Exosome secretion ameliorates lysosomal storage of cholesterol in Niemann-Pick type C disease.

Authors:  Katrin Strauss; Cornelia Goebel; Heiko Runz; Wiebke Möbius; Sievert Weiss; Ivo Feussner; Mikael Simons; Anja Schneider
Journal:  J Biol Chem       Date:  2010-06-16       Impact factor: 5.157

2.  Enteroviruses harness the cellular endocytic machinery to remodel the host cell cholesterol landscape for effective viral replication.

Authors:  Olha Ilnytska; Marianita Santiana; Nai-Yun Hsu; Wen-Li Du; Ying-Han Chen; Ekaterina G Viktorova; Georgy Belov; Anita Brinker; Judith Storch; Christopher Moore; Joseph L Dixon; Nihal Altan-Bonnet
Journal:  Cell Host Microbe       Date:  2013-09-11       Impact factor: 21.023

3.  Microarray analysis revealed different gene expression patterns in HepG2 cells treated with low and high concentrations of the extracts of Anacardium occidentale shoots.

Authors:  Shaghayegh Khaleghi; Azlina Abdul Aziz; Nurhanani Razali; Sarni Mat Junit
Journal:  Genes Nutr       Date:  2011-03-29       Impact factor: 5.523

4.  Quantitative detection of free 24S-hydroxycholesterol, and 27-hydroxycholesterol from human serum.

Authors:  Veera Venkata Ratnam Bandaru; Norman J Haughey
Journal:  BMC Neurosci       Date:  2014-12-24       Impact factor: 3.288

5.  Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.

Authors:  Marcus O W Grimm; Liesa Regner; Janine Mett; Christoph P Stahlmann; Pascal Schorr; Christopher Nelke; Olga Streidenberger; Hannah Stoetzel; Jakob Winkler; Shatha R Zaidan; Andrea Thiel; Kristina Endres; Heike S Grimm; Dietrich A Volmer; Tobias Hartmann
Journal:  Int J Mol Sci       Date:  2016-10-29       Impact factor: 5.923

Review 6.  Atherosclerosis and Alzheimer--diseases with a common cause? Inflammation, oxysterols, vasculature.

Authors:  Richard Lathe; Alexandra Sapronova; Yuri Kotelevtsev
Journal:  BMC Geriatr       Date:  2014-03-21       Impact factor: 3.921
  6 in total

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