Literature DB >> 20096156

Progress in understanding the immunopathogenesis of psoriasis.

R K H Mak1, C Hundhausen, F O Nestle.   

Abstract

This review emphasizes how translation from bench research to clinical knowledge and vice versa has resulted in considerable progress in understanding the immunopathogenesis of psoriasis. First, the journey in understanding the pathogenic mechanisms behind psoriasis is described. The roles of different components of the adaptive and innate immune systems involved in driving the inflammatory response are explained. Discovery of new immune pathways i.e. the IL23/Th17 axis and its subsequent impact on the development of novel biological therapies is highlighted. Identification of potential targets warranting further research for future therapeutic development are also discussed.

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Year:  2009        PMID： 20096156      PMCID： PMC2957885          DOI： 10.1016/s0001-7310(09)73372-1

Source DB:  PubMed          Journal:  Actas Dermosifiliogr        ISSN： 0001-7310


  98 in total

Review 1.  Psoriasis vulgaris: cutaneous lymphoid tissue supports T-cell activation and "Type 1" inflammatory gene expression.

Authors:  Wook Lew; Anne M Bowcock; James G Krueger
Journal:  Trends Immunol       Date:  2004-06       Impact factor: 16.687

Review 2.  Interleukin-10 in the regulation of T cell-induced colitis.

Authors:  Oliver Annacker; Chrystelle Asseman; Simon Read; Fiona Powrie
Journal:  J Autoimmun       Date:  2003-06       Impact factor: 7.094

3.  Psoriasis patients who are homozygous for the HLA-Cw*0602 allele have a 2.5-fold increased risk of developing psoriasis compared with Cw6 heterozygotes.

Authors:  J E Gudjonsson; A Karason; A Antonsdottir; E H Runarsdottir; V B Hauksson; R Upmanyu; J Gulcher; K Stefansson; H Valdimarsson
Journal:  Br J Dermatol       Date:  2003-02       Impact factor: 9.302

Review 4.  Adalimumab: efficacy and safety in psoriasis and rheumatoid arthritis.

Authors:  Toral Patel; Kenneth B Gordon
Journal:  Dermatol Ther       Date:  2004       Impact factor: 2.851

5.  Peripheral blood T cell responses to keratin peptides that share sequences with streptococcal M proteins are largely restricted to skin-homing CD8(+) T cells.

Authors:  A Johnston; J E Gudjonsson; H Sigmundsdottir; T J Love; H Valdimarsson
Journal:  Clin Exp Immunol       Date:  2004-10       Impact factor: 4.330

Review 6.  Prevalence of joint disease in patients with psoriasis: implications for therapy.

Authors:  Hugh Zachariae
Journal:  Am J Clin Dermatol       Date:  2003       Impact factor: 7.403

7.  In psoriasis lesional skin the type I interferon signaling pathway is activated, whereas interferon-alpha sensitivity is unaltered.

Authors:  Leslie van der Fits; Leontine I van der Wel; Jon D Laman; Errol P Prens; Martie C M Verschuren
Journal:  J Invest Dermatol       Date:  2004-01       Impact factor: 8.551

8.  TGF-beta 1 plays an important role in the mechanism of CD4+CD25+ regulatory T cell activity in both humans and mice.

Authors:  Kazuhiko Nakamura; Atsushi Kitani; Ivan Fuss; Aasta Pedersen; Naohiko Harada; Hajime Nawata; Warren Strober
Journal:  J Immunol       Date:  2004-01-15       Impact factor: 5.422

9.  Etanercept as monotherapy in patients with psoriasis.

Authors:  Craig L Leonardi; Jerold L Powers; Robert T Matheson; Bernard S Goffe; Ralph Zitnik; Andrea Wang; Alice B Gottlieb
Journal:  N Engl J Med       Date:  2003-11-20       Impact factor: 91.245

10.  Spontaneous development of psoriasis in a new animal model shows an essential role for resident T cells and tumor necrosis factor-alpha.

Authors:  Onur Boyman; Hans Peter Hefti; Curdin Conrad; Brian J Nickoloff; Mark Suter; Frank O Nestle
Journal:  J Exp Med       Date:  2004-02-23       Impact factor: 14.307
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  32 in total

1.  Identification of cell types, tissues and pathways affected by risk loci in psoriasis.

Authors:  Yan Lin; Pan Zhao; Changbing Shen; Songke Shen; Xiaodong Zheng; Xianbo Zuo; Sen Yang; Xuejun Zhang; Xianyong Yin
Journal:  Mol Genet Genomics       Date:  2015-11-12       Impact factor: 3.291

2.  Genetic Epidemiology of Psoriasis.

Authors:  Rashmi Gupta; Maya G Debbaneh; Wilson Liao
Journal:  Curr Dermatol Rep       Date:  2014-03

3.  In vivo induction of cutaneous inflammation results in the accumulation of extracellular trap-forming neutrophils expressing RORγt and IL-17.

Authors:  Romy R M C Keijsers; Anke G M Hendriks; Piet E J van Erp; Bram van Cranenbroek; Peter C M van de Kerkhof; Hans J P M Koenen; Irma Joosten
Journal:  J Invest Dermatol       Date:  2013-12-06       Impact factor: 8.551

4.  MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.

Authors:  Ruifang Wu; Jinrong Zeng; Jin Yuan; Xinjie Deng; Yi Huang; Lina Chen; Peng Zhang; Huan Feng; Zixin Liu; Zijun Wang; Xiaofei Gao; Haijing Wu; Honglin Wang; Yuwen Su; Ming Zhao; Qianjin Lu
Journal:  J Clin Invest       Date:  2018-05-14       Impact factor: 14.808

5.  GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.

Authors:  Xichun Xia; Guangchao Cao; Guodong Sun; Leqing Zhu; Yixia Tian; Yueqi Song; Chengbin Guo; Xiao Wang; Jingxiang Zhong; Wei Zhou; Peng Li; Hua Zhang; Jianlei Hao; Zhizhong Li; Liehua Deng; Zhinan Yin; Yunfei Gao
Journal:  J Clin Invest       Date:  2020-10-01       Impact factor: 14.808

6.  Psoriasiform Sarcoidosis: Collision of Two Entities or Expression of One Common Pathogenesis?

Authors:  Miriam L Vega; Jennifer Abrahams; Matthew Keller
Journal:  J Clin Aesthet Dermatol       Date:  2016-04-01

Review 7.  Psoriasis.

Authors:  Paola Di Meglio; Federica Villanova; Frank O Nestle
Journal:  Cold Spring Harb Perspect Med       Date:  2014-08-01       Impact factor: 6.915

Review 8.  microRNAs involved in psoriasis and cardiovascular diseases.

Authors:  Sara Sileno; Sara Beji; Marco D'Agostino; Alessandra Carassiti; Guido Melillo; Alessandra Magenta
Journal:  Vasc Biol       Date:  2021-06-03

9.  CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis.

Authors:  Mariana D Batista; Camilla Tincati; Jeffrey M Milush; Emily L Ho; Lishomwa C Ndhlovu; Vanessa A York; Esper G Kallas; Jorge Kalil; Sheila M Keating; Philip J Norris; David Chang; Patrick Unemori; Kieron S Leslie; Toby Maurer; Wilson Liao; Douglas F Nixon
Journal:  PLoS One       Date:  2013-02-28       Impact factor: 3.240

10.  Tumor necrosis factor-α gene promoter -308 and -238 polymorphisms and its serum level in psoriasis.

Authors:  Magda M Hagag; Mai M Ghazy; Nesreen G Elhelbawy
Journal:  Biochem Biophys Rep       Date:  2021-06-12
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