Miriam L Vega1, Jennifer Abrahams2, Matthew Keller1. 1. Thomas Jefferson University, Philadelphia, Pennsylvania; 2. University of Miami Department of Dermatology, Miami, Florida.
Abstract
BACKGROUND: Psoriasiform lesions are an established, but rare, manifestation of sarcoidosis. Only 0.9 percent of patients with cutaneous sarcoidosis develop this form of the disease. OBSERVATION: The authors present a case of a 61-year-old woman with a history of pulmonary sarcoidosis who presented to their dermatology clinic with thick plaques resembling psoriasis. Biopsy of one of the lesions revealed sarcoidal granulomas in association with psoriasiform changes. CONCLUSION: Psoriasiform lesions are a rare manifestation of sarcoidosis. The authors theorize that the co-expression of TNF-α in both entities is a possible explanation of the psoriasiform expression of sarcoidosis.
BACKGROUND: Psoriasiform lesions are an established, but rare, manifestation of sarcoidosis. Only 0.9 percent of patients with cutaneous sarcoidosis develop this form of the disease. OBSERVATION: The authors present a case of a 61-year-old woman with a history of pulmonary sarcoidosis who presented to their dermatology clinic with thick plaques resembling psoriasis. Biopsy of one of the lesions revealed sarcoidal granulomas in association with psoriasiform changes. CONCLUSION: Psoriasiform lesions are a rare manifestation of sarcoidosis. The authors theorize that the co-expression of TNF-α in both entities is a possible explanation of the psoriasiform expression of sarcoidosis.
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