Literature DB >> 20093754

Drug resistance in leprosy.

Masanori Matsuoka1.   

Abstract

Leprosy is caused by Mycobacterium leprae. Currently, leprosy control is mainly based on WHO-recommended multi-drug treatment; thus, emergence of drug resistance is a major concern. M. leprae isolates resistant to single and multiple drugs have been encountered. In this review, the history of chemotherapy and drug resistance in leprosy and molecular biological insights for drug resistance are described. New methodologies to test susceptibility to anti-leprosy drugs instead of the traditional mouse footpad method are introduced. Awareness of the need to monitor drug resistance to prevent the spread of resistant cases is emphasized.

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Year:  2010        PMID： 20093754

Source DB:  PubMed          Journal:  Jpn J Infect Dis        ISSN： 1344-6304            Impact factor:   1.362


  15 in total

1.  Real-time PCR and high-resolution melt analysis for rapid detection of Mycobacterium leprae drug resistance mutations and strain types.

Authors:  Wei Li; Masanori Matsuoka; Masanori Kai; Pratibha Thapa; Saraswoti Khadge; Deanna A Hagge; Patrick J Brennan; Varalakshmi Vissa
Journal:  J Clin Microbiol       Date:  2011-12-14       Impact factor: 5.948

2.  Molecular drug susceptibility testing and genotyping of Mycobacterium leprae strains from South America.

Authors:  Pushpendra Singh; Philippe Busso; Alberto Paniz-Mondolfi; Nacarid Aranzazu; Marc Monot; Nadine Honore; Andrea de Faria Fernandes Belone; Marcos Virmond; Maria Esther Villarreal-Olaya; Carlos Rivas; Stewart T Cole
Journal:  Antimicrob Agents Chemother       Date:  2011-03-28       Impact factor: 5.191

3.  Identification of primary drug resistance to rifampin in Mycobacterium leprae strains from leprosy patients in Amazonas State, Brazil.

Authors:  Matilde Del Carmen Contreras Mejía; Maísa Porto Dos Santos; George Allan Villarouco da Silva; Isabella da Motta Passos; Felipe Gomes Naveca; Maria da Graça Souza Cunha; Milton Ozório Moraes; Lucia de Paula
Journal:  J Clin Microbiol       Date:  2014-10-01       Impact factor: 5.948

4.  Murine experimental leprosy: Evaluation of immune response by analysis of peritoneal lavage cells and footpad histopathology.

Authors:  Fátima Regina Vilani-Moreno; Adriana Sierra Assêncio Almeida Barbosa; Beatriz Gomes Carreira Sartori; Suzana Madeira Diório; Sônia Maria Usó Ruiz Silva; Patrícia Sammarco Rosa; Andréa de Faria Fernandes Belone; Cleverson Teixeira Soares; José Roberto Pereira Lauris; Sílvia Cristina Barboza Pedrini
Journal:  Int J Exp Pathol       Date:  2019-05-24       Impact factor: 1.925

5.  Transmission of dapsone-resistant leprosy detected by molecular epidemiological approaches.

Authors:  Wei Li; Rama M Sakamuri; Danielle E Lyons; Florenda M Orcullo; Vidyagouri Shinde; Edred Lao Dela Pena; Armi A Maghanoy; Irene B Mallari; Esterlina V Tan; Indira Nath; Patrick J Brennan; Marivic Balagon; Varalakshmi Vissa
Journal:  Antimicrob Agents Chemother       Date:  2011-08-22       Impact factor: 5.191

Review 6.  Mycobacterium leprae: genes, pseudogenes and genetic diversity.

Authors:  Pushpendra Singh; Stewart T Cole
Journal:  Future Microbiol       Date:  2011-01       Impact factor: 3.165

7.  Antimicrobial Resistance among Leprosy Patients in Brazil: Real-World Data Based on the National Surveillance Plan.

Authors:  Elaine Silva Nascimento Andrade; Jurema Guerrieri Brandão; Juliana Souza da Silva; Carmelita Ribeiro Filha Coriolano; Patricia Sammarco Rosa; Milton Ozório Moraes; Cynthia de Oliveira Ferreira; Ciro Martins Gomes; Wildo Navegantes de Araújo
Journal:  Antimicrob Agents Chemother       Date:  2022-04-18       Impact factor: 5.938

8.  Human polymorphisms as clinical predictors in leprosy.

Authors:  Ernesto Prado Montes de Oca
Journal:  J Trop Med       Date:  2011-12-18

9.  Structural Implications of Mutations Conferring Rifampin Resistance in Mycobacterium leprae.

Authors:  Sundeep Chaitanya Vedithi; Sony Malhotra; Madhusmita Das; Sheela Daniel; Nanda Kishore; Anuja George; Shantha Arumugam; Lakshmi Rajan; Mannam Ebenezer; David B Ascher; Eddy Arnold; Tom L Blundell
Journal:  Sci Rep       Date:  2018-03-22       Impact factor: 4.379

10.  qPCR-High resolution melt analysis for drug susceptibility testing of Mycobacterium leprae directly from clinical specimens of leprosy patients.

Authors:  Sergio Araujo; Luiz Ricardo Goulart; Richard W Truman; Isabela Maria B Goulart; Varalakshmi Vissa; Wei Li; Masanori Matsuoka; Philip Suffys; Amanda B Fontes; Patricia S Rosa; David M Scollard; Diana L Williams
Journal:  PLoS Negl Trop Dis       Date:  2017-06-01
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