Literature DB >> 20091013

Generation of oxygen gradients with arbitrary shapes in a microfluidic device.

Micha Adler1, Mark Polinkovsky, Edgar Gutierrez, Alex Groisman.   

Abstract

We present a system consisting of a microfluidic device made of gas-permeable polydimethylsiloxane (PDMS) with two layers of microchannels and a computer-controlled multi-channel gas mixer. Concentrations of oxygen in the liquid-filled flow channels of the device are imposed by flowing gas mixtures with desired oxygen concentrations through gas channels directly above the flow channels. Oxygen gradients with different linear, exponential, and non-monotonic shapes are generated in the same liquid-filled microchannel and reconfigured in real time. The system can be used to study directed migration of cells and the development of cell and tissue cultures under gradients of oxygen.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 20091013      PMCID： PMC2887752          DOI： 10.1039/b920401f

Source DB:  PubMed          Journal:  Lab Chip        ISSN： 1473-0189            Impact factor:   6.799


  18 in total

1.  Development of an integrated microfluidic platform for dynamic oxygen sensing and delivery in a flowing medium.

Authors:  Adam P Vollmer; Ronald F Probstein; Richard Gilbert; Todd Thorsen
Journal:  Lab Chip       Date:  2005-08-25       Impact factor: 6.799

2.  Generation of complex concentration profiles in microchannels in a logarithmically small number of steps.

Authors:  Kyle Campbell; Alex Groisman
Journal:  Lab Chip       Date:  2006-11-27       Impact factor: 6.799

3.  Sickle cell vasoocclusion and rescue in a microfluidic device.

Authors:  J M Higgins; D T Eddington; S N Bhatia; L Mahadevan
Journal:  Proc Natl Acad Sci U S A       Date:  2007-12-12       Impact factor: 11.205

Review 4.  Aerotaxis and other energy-sensing behavior in bacteria.

Authors:  B L Taylor; I B Zhulin; M S Johnson
Journal:  Annu Rev Microbiol       Date:  1999       Impact factor: 15.500

5.  Formation of steady-state oxygen gradients in vitro: application to liver zonation.

Authors:  Jared W Allen; Sangeeta N Bhatia
Journal:  Biotechnol Bioeng       Date:  2003-05-05       Impact factor: 4.530

6.  Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture.

Authors:  Geeta Mehta; Khamir Mehta; Dhruv Sud; Jonathan W Song; Tommaso Bersano-Begey; Nobuyuki Futai; Yun Seok Heo; Mary-Ann Mycek; Jennifer J Linderman; Shuichi Takayama
Journal:  Biomed Microdevices       Date:  2007-04       Impact factor: 2.838

7.  A microsystem for sensing and patterning oxidative microgradients during cell culture.

Authors:  Jaehyun Park; Tushar Bansal; Mikhail Pinelis; Michel M Maharbiz
Journal:  Lab Chip       Date:  2006-03-16       Impact factor: 6.799

8.  Fine temporal control of the medium gas content and acidity and on-chip generation of series of oxygen concentrations for cell cultures.

Authors:  Mark Polinkovsky; Edgar Gutierrez; Andre Levchenko; Alex Groisman
Journal:  Lab Chip       Date:  2009-02-17       Impact factor: 6.799

9.  Oxygen sensation and social feeding mediated by a C. elegans guanylate cyclase homologue.

Authors:  Jesse M Gray; David S Karow; Hang Lu; Andy J Chang; Jennifer S Chang; Ronald E Ellis; Michael A Marletta; Cornelia I Bargmann
Journal:  Nature       Date:  2004-06-27       Impact factor: 49.962

Review 10.  Hypoxia and oxidative stress in breast cancer. Hypoxia and tumourigenesis.

Authors:  H J Knowles; A L Harris
Journal:  Breast Cancer Res       Date:  2001-07-17       Impact factor: 6.466
View more
  39 in total

Review 1.  Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations.

Authors:  Kristina R Rivera; Murat A Yokus; Patrick D Erb; Vladimir A Pozdin; Michael Daniele
Journal:  Analyst       Date:  2019-05-13       Impact factor: 4.616

2.  Imaging in real-time with FRET the redox response of tumorigenic cells to glutathione perturbations in a microscale flow.

Authors:  Chunchen Lin; Vladimir L Kolossov; Gene Tsvid; Lisa Trump; Jennifer Jo Henry; Jerrod L Henderson; Laurie A Rund; Paul J A Kenis; Lawrence B Schook; H Rex Gaskins; Gregory Timp
Journal:  Integr Biol (Camb)       Date:  2010-12-23       Impact factor: 2.192

3.  Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems.

Authors:  Felipe T Lee-Montiel; Subin M George; Albert H Gough; Anup D Sharma; Juanfang Wu; Richard DeBiasio; Lawrence A Vernetti; D Lansing Taylor
Journal:  Exp Biol Med (Maywood)       Date:  2017-04-14

4.  A high-throughput photodynamic therapy screening platform with on-chip control of multiple microenvironmental factors.

Authors:  Xia Lou; Gwangseong Kim; Hyung Ki Yoon; Yong-Eun Koo Lee; Raoul Kopelman; Euisik Yoon
Journal:  Lab Chip       Date:  2014-03-07       Impact factor: 6.799

5.  Generation of nitric oxide gradients in microfluidic devices for cell culture using spatially controlled chemical reactions.

Authors:  Ying-Hua Chen; Chien-Chung Peng; Yung-Ju Cheng; Jin-Gen Wu; Yi-Chung Tung
Journal:  Biomicrofluidics       Date:  2013-11-07       Impact factor: 2.800

6.  A Customizable Chamber for Measuring Cell Migration.

Authors:  Aniqa N Chowdhury; Huu Tri Vo; Sharon Olang; Elliott Mappus; Brian Peterson; Nora Hlavac; Tyler Harvey; Delphine Dean
Journal:  J Vis Exp       Date:  2017-03-12       Impact factor: 1.355

7.  Microfluidic platform generates oxygen landscapes for localized hypoxic activation.

Authors:  Megan L Rexius-Hall; Gerardo Mauleon; Asrar B Malik; Jalees Rehman; David T Eddington
Journal:  Lab Chip       Date:  2014-10-15       Impact factor: 6.799

8.  O2-controllable hydrogels for studying cellular responses to hypoxic gradients in three dimensions in vitro and in vivo.

Authors:  Daniel M Lewis; Michael R Blatchley; Kyung Min Park; Sharon Gerecht
Journal:  Nat Protoc       Date:  2017-07-20       Impact factor: 13.491

Review 9.  Microfluidics expanding the frontiers of microbial ecology.

Authors:  Roberto Rusconi; Melissa Garren; Roman Stocker
Journal:  Annu Rev Biophys       Date:  2014       Impact factor: 12.981

10.  Cancer cell migration and cancer drug screening in oxygen tension gradient chip.

Authors:  Hyeono Nam; Kenichi Funamoto; Jessie S Jeon
Journal:  Biomicrofluidics       Date:  2020-07-21       Impact factor: 2.800
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.