Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Engineering signal transduction pathways.

Literature DB >> 20085704

Engineering signal transduction pathways.

Abstract

Cells respond to their environment by sensing signals and translating them into changes in gene expression. In recent years, synthetic networks have been designed in both prokaryotic and eukaryotic systems to create new functionalities and for specific applications. In this review, we discuss the challenges associated with engineering signal transduction pathways. Furthermore, we address advantages and disadvantages of engineering signaling pathways in prokaryotic and eukaryotic cells, highlighting recent examples, and discuss how progress in synthetic biology might impact biotechnology and biomedicine.

Entities: Chemical

Mesh：

Year: 2010 PMID： 20085704 DOI： 10.1016/j.cell.2009.12.028

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

Keyword Cloud
Cited

40 in total

1. Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

Authors: Malte Paulsen; Stefan Legewie; Roland Eils; Emil Karaulanov; Christof Niehrs
Journal: Proc Natl Acad Sci U S A Date: 2011-06-01 Impact factor: 11.205

Review 2. Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods.

Authors: T Scott Chen; Amy E Keating
Journal: Protein Sci Date: 2012-06-08 Impact factor: 6.725

Review 3. Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.

Authors: Prasanta K Hota; Matthias Buck
Journal: Cell Mol Life Sci Date: 2012-06-29 Impact factor: 9.261

4. Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach.

Authors: Aman Chandra Kaushik; Shakti Sahi
Journal: Syst Synth Biol Date: 2015-03-14

Engineering signal transduction pathways.

1. Negative feedback in the bone morphogenetic protein 4 (BMP4) synexpression group governs its dynamic signaling range and canalizes development.

Review 2. Designing specific protein-protein interactions using computation, experimental library screening, or integrated methods.

Review 3. Plexin structures are coming: opportunities for multilevel investigations of semaphorin guidance receptors, their cell signaling mechanisms, and functions.

4. Boolean network model for GPR142 against Type 2 diabetes and relative dynamic change ratio analysis using systems and biological circuits approach.

5. Building a synthetic mechanosensitive signaling pathway in compartmentalized artificial cells.

6. Piconewton-Scale Analysis of Ras-BRaf Signal Transduction with Single-Molecule Force Spectroscopy.

7. Spatiotemporal control of microtubule nucleation and assembly using magnetic nanoparticles.

Review 8. Protein engineering: a new frontier for biological therapeutics.

9. Engineering Synthetic Multistress Tolerance in Escherichia coli by Using a Deinococcal Response Regulator, DR1558.

Review 10. Synthetic biology approaches in drug discovery and pharmaceutical biotechnology.