Hu Yayi1, Wang Danqing, Liu Shuyun, Liu Jicheng. 1. Department of Obstetrics and Gynecology, The Second West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Abstract
PROBLEM: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy risk because of the possibility of pre-term delivery and sudden intrauterine fetal death. Its pathogenesis is still under discussion. METHOD OF STUDY: The analysis of the recent findings on the complex immunologic events that occur in ICP were performed. RESULTS: In ICP, an increase of type 1 cytokine (TNF-alpha, IFN-gamma) associated with a decrease of type 2 cytokine (IL-4). The decreased production of the suppressor cytokine TGF-beta2 may increase the type 1 cytokine. Fas appeared to be increased and FasL appeared to be decreased in syncytiotrophoblasts of ICP. The human leukocyte antigen gene (HLA-G, E) in extravillous trophoblasts of ICP were significantly decreased. CONCLUSION: Th1/Th2 cytokine balance and HLA play important roles in the tolerance and maintenance of pregnancy. ICP may be resulting from breach of the maternal fetal immune tolerance during pregnancy.
PROBLEM: Intrahepatic cholestasis of pregnancy (ICP) is a pregnancy risk because of the possibility of pre-term delivery and sudden intrauterine fetal death. Its pathogenesis is still under discussion. METHOD OF STUDY: The analysis of the recent findings on the complex immunologic events that occur in ICP were performed. RESULTS: In ICP, an increase of type 1 cytokine (TNF-alpha, IFN-gamma) associated with a decrease of type 2 cytokine (IL-4). The decreased production of the suppressor cytokine TGF-beta2 may increase the type 1 cytokine. Fas appeared to be increased and FasL appeared to be decreased in syncytiotrophoblasts of ICP. The human leukocyte antigen gene (HLA-G, E) in extravillous trophoblasts of ICP were significantly decreased. CONCLUSION:Th1/Th2 cytokine balance and HLA play important roles in the tolerance and maintenance of pregnancy. ICP may be resulting from breach of the maternal fetal immune tolerance during pregnancy.
Authors: Nazan Yurtcu; Canan Soyer Caliskan; Huri Guvey; Samettin Celik; Safak Hatirnaz; Andrea Tinelli Journal: Int J Environ Res Public Health Date: 2022-02-16 Impact factor: 3.390