Literature DB >> 20085489

Application of biochemical markers in development of drugs for treatment of osteoarthritis.

Per Qvist1, Claus Christiansen, Morten A Karsdal, Suzi Høgh Madsen, Bodil Cecilie Sondergaard, Anne-Christine Bay-Jensen.   

Abstract

Osteoarthritis is a chronic disease for which no efficacious medical intervention is yet available. Recent disappointments in late-stage clinical development of disease-modifying osteoarthritic drugs (DMOADs) have precipitated efforts in biomarker discovery aimed at developing an analytical tool box with the potential to improve the clinical development process. In this review, we seek to provide an overview of the biochemical marker repertoire currently available with a special focus on data originating from their application in clinical development programmes. Finally, we discuss possible directions in future biomarker research.

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Year:  2010        PMID： 20085489     DOI： 10.3109/13547500903295873

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  9 in total

1.  Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T MRI - an analysis from the incidence cohort of the Osteoarthritis Initiative.

Authors:  J Pan; C Stehling; C Muller-Hocker; B J Schwaiger; J Lynch; C E McCulloch; M C Nevitt; T M Link
Journal:  Osteoarthritis Cartilage       Date:  2010-10-31       Impact factor: 6.576

Review 2.  Extracellular matrix remodeling: the common denominator in connective tissue diseases. Possibilities for evaluation and current understanding of the matrix as more than a passive architecture, but a key player in tissue failure.

Authors:  Morten A Karsdal; Mette J Nielsen; Jannie M Sand; Kim Henriksen; Federica Genovese; Anne-Christine Bay-Jensen; Victoria Smith; Joanne I Adamkewicz; Claus Christiansen; Diana J Leeming
Journal:  Assay Drug Dev Technol       Date:  2012-10-09       Impact factor: 1.738

3.  Alpha C-telopeptide of type I collagen is associated with subchondral bone turnover and predicts progression of joint space narrowing and osteophytes in osteoarthritis.

Authors:  Janet L Huebner; Anne C Bay-Jensen; Kim M Huffman; Yi He; Diana J Leeming; Gary E McDaniel; Morten A Karsdal; Virginia B Kraus
Journal:  Arthritis Rheumatol       Date:  2014-09       Impact factor: 10.995

4.  Pharmacologic regimens for knee osteoarthritis prevention: can they be cost-effective?

Authors:  E Losina; S A Burbine; L G Suter; D J Hunter; D H Solomon; M E Daigle; E E Dervan; J M Jordan; J N Katz
Journal:  Osteoarthritis Cartilage       Date:  2014-01-31       Impact factor: 6.576

5.  Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.

Authors:  Maureen Pickarski; Tadashi Hayami; Ya Zhuo; Le T Duong
Journal:  BMC Musculoskelet Disord       Date:  2011-08-24       Impact factor: 2.362

Review 6.  Biochemical markers of ongoing joint damage in rheumatoid arthritis--current and future applications, limitations and opportunities.

Authors:  Morten A Karsdal; Thasia Woodworth; Kim Henriksen; Walter P Maksymowych; Harry Genant; Philippe Vergnaud; Claus Christiansen; Tanja Schubert; Per Qvist; Georg Schett; Adam Platt; Anne-Christine Bay-Jensen
Journal:  Arthritis Res Ther       Date:  2011-04-28       Impact factor: 5.156

7.  Mitochondrial DNA (mtDNA) haplogroups and serum levels of anti-oxidant enzymes in patients with osteoarthritis.

Authors:  Mercedes Fernandez-Moreno; Angel Soto-Hermida; Sonia Pertega; Natividad Oreiro; Carlos Fernandez-Lopez; Ignacio Rego-Perez; Francisco J Blanco
Journal:  BMC Musculoskelet Disord       Date:  2011-11-22       Impact factor: 2.362

8.  Applications of proteomics to osteoarthritis, a musculoskeletal disease characterized by aging.

Authors:  Ali Mobasheri
Journal:  Front Physiol       Date:  2011-12-23       Impact factor: 4.566

9.  Analysis of mass spectrometry data from the secretome of an explant model of articular cartilage exposed to pro-inflammatory and anti-inflammatory stimuli using machine learning.

Authors:  Anna L Swan; Kirsty L Hillier; Julia R Smith; David Allaway; Susan Liddell; Jaume Bacardit; Ali Mobasheri
Journal:  BMC Musculoskelet Disord       Date:  2013-12-13       Impact factor: 2.362
  9 in total

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