Literature DB >> 20077118

Evolution of the ancestral recombination graph along the genome in case of selective sweep.

Stephanie Leocard1, Etienne Pardoux.   

Abstract

We consider the genome of a sample of n individuals taken at the end of a selective sweep, which is the fixation of an advantageous allele in the population. When the selective advantage is high, the genealogy at a locus under selective sweep can be approximated by a comb with n teeth. However, because of recombinations during the selective sweep, the hitchhiking effect decreases as the distance from the selected site increases, so that far from this locus, the tree can be approximated by a Kingman coalescent tree, as in the neutral case. We first give the distribution of the tree at a given locus. Then we focus on the evolution of this tree along the genome. Since this tree-valued process is not Markovian, we study the evolution of the Ancestral Recombination Graph along the genome in case of selective sweep.

Mesh:

Year:  2010        PMID: 20077118     DOI: 10.1007/s00285-009-0321-4

Source DB:  PubMed          Journal:  J Math Biol        ISSN: 0303-6812            Impact factor:   2.259


  8 in total

1.  Recombination as a point process along sequences.

Authors:  C Wiuf; J Hein
Journal:  Theor Popul Biol       Date:  1999-06       Impact factor: 1.570

2.  Extinction time and age of an allele in a large finite population.

Authors:  Onno A van Herwaarden; Nathalie J van der Wal
Journal:  Theor Popul Biol       Date:  2002-05       Impact factor: 1.570

3.  Genomic scans for selective sweeps using SNP data.

Authors:  Rasmus Nielsen; Scott Williamson; Yuseob Kim; Melissa J Hubisz; Andrew G Clark; Carlos Bustamante
Journal:  Genome Res       Date:  2005-11       Impact factor: 9.043

4.  The structure of linkage disequilibrium around a selective sweep.

Authors:  Gil McVean
Journal:  Genetics       Date:  2006-12-28       Impact factor: 4.562

5.  The hitchhiking effect on linkage disequilibrium between linked neutral loci.

Authors:  Wolfgang Stephan; Yun S Song; Charles H Langley
Journal:  Genetics       Date:  2006-02-01       Impact factor: 4.562

6.  Approximating genealogies for partially linked neutral loci under a selective sweep.

Authors:  P Pfaffelhuber; A Studeny
Journal:  J Math Biol       Date:  2007-03-30       Impact factor: 2.259

7.  The hitch-hiking effect of a favourable gene.

Authors:  J M Smith; J Haigh
Journal:  Genet Res       Date:  1974-02       Impact factor: 1.588

8.  Properties of a neutral allele model with intragenic recombination.

Authors:  R R Hudson
Journal:  Theor Popul Biol       Date:  1983-04       Impact factor: 1.570

  8 in total
  2 in total

1.  Selective sweeps for recessive alleles and for other modes of dominance.

Authors:  G Ewing; J Hermisson; P Pfaffelhuber; J Rudolf
Journal:  J Math Biol       Date:  2010-11-13       Impact factor: 2.259

2.  USING POPULATION GENOMICS TO DETECT SELECTION IN NATURAL POPULATIONS: KEY CONCEPTS AND METHODOLOGICAL CONSIDERATIONS.

Authors:  Paul A Hohenlohe; Patrick C Phillips; William A Cresko
Journal:  Int J Plant Sci       Date:  2010-11-01       Impact factor: 1.785

  2 in total

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