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Literature DB >> 2007259

Immunohistochemical localization of porcine diazepam-binding inhibitor (DBI) to rat endocrine pancreas.

O Johansson¹, M Hilliges, C G Ostenson, E Sandberg, S Efendic, V Mutt.

Abstract

The occurrence of diazepam-binding inhibitor (DBI), isolated and characterized from porcine upper intestine, was examined in the pancreas of Sprague-Dawley albino rats using indirect immunofluorescence. The polypeptide was found in the endocrine Langerhans islets and, utilizing double-labelling controls, it was shown to be present within the peripherally located glucagon-containing cells. Regulation of islet hormone production may therefore be under DBI control.

Entities: Disease Gene Species

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Year: 1991 PMID： 2007259 DOI： 10.1007/bf00318781

Source DB: PubMed Journal: Cell Tissue Res ISSN： 0302-766X Impact factor: 5.249

5 in total

1. Acyl-CoA-binding protein in the rat. Purification, binding characteristics, tissue concentrations and amino acid sequence.

Authors: J Knudsen; P Højrup; H O Hansen; H F Hansen; P Roepstorff
Journal: Biochem J Date: 1989-09-01 Impact factor: 3.857

2. Isolation and characterization of porcine diazepam-binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release.

Authors: Z W Chen; B Agerberth; K Gell; M Andersson; V Mutt; C G Ostenson; S Efendić; J Barros-Söderling; B Persson; H Jörnvall
Journal: Eur J Biochem Date: 1988-06-01

3. The use of dopamine -hydroxylase as a marker for the central noradrenergic nervous system in rat brain.

Authors: B K Hartman; D Zide; S Udenfriend
Journal: Proc Natl Acad Sci U S A Date: 1972-09 Impact factor: 11.205

4. Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.

Authors: P Ferrero; M R Santi; B Conti-Tronconi; E Costa; A Guidotti
Journal: Proc Natl Acad Sci U S A Date: 1986-02 Impact factor: 11.205

5. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

Authors: A Guidotti; C M Forchetti; M G Corda; D Konkel; C D Bennett; E Costa
Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

5 in total

3 in total

Immunohistochemical localization of porcine diazepam-binding inhibitor (DBI) to rat endocrine pancreas.

1. Acyl-CoA-binding protein in the rat. Purification, binding characteristics, tissue concentrations and amino acid sequence.

2. Isolation and characterization of porcine diazepam-binding inhibitor, a polypeptide not only of cerebral occurrence but also common in intestinal tissues and with effects on regulation of insulin release.

3. The use of dopamine -hydroxylase as a marker for the central noradrenergic nervous system in rat brain.

4. Study of an octadecaneuropeptide derived from diazepam binding inhibitor (DBI): biological activity and presence in rat brain.

5. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

1. DBI mRNA is expressed in endocrine pancreas and its post-translational product DBI(33-50) inhibits insulin release.

2. Immunoreactive endozepine-like peptides in the brain and pituitary of the Atlantic hagfish, Myxine glutinosa.

3. Diazepam binding inhibitor is a potent cholecystokinin-releasing peptide in the intestine.