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Literature DB >> 21153173

DBI mRNA is expressed in endocrine pancreas and its post-translational product DBI(33-50) inhibits insulin release.

P Borboni¹, R Magnaterra, O Porzio, A Fusco, G Sesti, A Bertoli, R Lauro, L N Marlier.

Abstract

It has been previously demonstrated that DBI is present in endocrine pancreas and it is able to inhibit insulin release in isolated rat islets. Its mechanism of action has been investigated, demonstrating the possible involvement of cAMP and ATP-dependent K(+) channels. DB1(33-50), a post-translational product of DBI, is also able to inhibit insulin release, but its action has not been characterized. In the present study, we have investigated the presence of DBI mRNA in pancreas, islets and cultured ß cells. The possible mechanism of action of DBI(33-50) and the involvement of BZ/GABA(A) receptors has been studied.

Entities: Chemical Disease Gene Species

Year: 1995 PMID： 21153173 DOI： 10.1007/BF03021404

Source DB: PubMed Journal: Endocrine ISSN： 1355-008X Impact factor: 3.633

40 in total

Review 1. Cholecystokinin and the regulation of insulin secretion.

Authors: S Karlsson; B Ahrén
Journal: Scand J Gastroenterol Date: 1992 Impact factor: 2.423

2. Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

Authors: K W Kinnally; D B Zorov; Y N Antonenko; S H Snyder; M W McEnery; H Tedeschi
Journal: Proc Natl Acad Sci U S A Date: 1993-02-15 Impact factor: 11.205

3. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis.

Authors: V Papadopoulos; A G Mukhin; E Costa; K E Krueger
Journal: J Biol Chem Date: 1990-03-05 Impact factor: 5.157

4. Method for large-scale isolation of pancreatic islets by tissue culture of fetal rat pancreas.

Authors: C H Hellerström; N J Lewis; H Borg; R Johnson; N Fréinkel
Journal: Diabetes Date: 1979-08 Impact factor: 9.461

5. Coated charcoal immunoassay of insulin.

Authors: V Herbert; K S Lau; C W Gottlieb; S J Bleicher
Journal: J Clin Endocrinol Metab Date: 1965-10 Impact factor: 5.958

6. Role of cyclic AMP in insulin release evoked by glucose and other secretagogues.

Authors: V Grill
Journal: Horm Metab Res Suppl Date: 1980

7. Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat.

Authors: P Bovolin; J Schlichting; M Miyata; C Ferrarese; A Guidotti; H Alho
Journal: Regul Pept Date: 1990-07-30

Review 8. Molecular biology of GABAA receptors.

Authors: R W Olsen; A J Tobin
Journal: FASEB J Date: 1990-03 Impact factor: 5.191

9. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.

Authors: V Papadopoulos; P Guarneri; K E Kreuger; A Guidotti; E Costa
Journal: Proc Natl Acad Sci U S A Date: 1992-06-01 Impact factor: 11.205

10. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

Authors: A Guidotti; C M Forchetti; M G Corda; D Konkel; C D Bennett; E Costa
Journal: Proc Natl Acad Sci U S A Date: 1983-06 Impact factor: 11.205

5 in total

DBI mRNA is expressed in endocrine pancreas and its post-translational product DBI(33-50) inhibits insulin release.

Review 1. Cholecystokinin and the regulation of insulin secretion.

2. Mitochondrial benzodiazepine receptor linked to inner membrane ion channels by nanomolar actions of ligands.

3. The peripheral-type benzodiazepine receptor is functionally linked to Leydig cell steroidogenesis.

4. Method for large-scale isolation of pancreatic islets by tissue culture of fetal rat pancreas.

5. Coated charcoal immunoassay of insulin.

6. Role of cyclic AMP in insulin release evoked by glucose and other secretagogues.

7. Distribution and characterization of diazepam binding inhibitor (DBI) in peripheral tissues of rat.

Review 8. Molecular biology of GABAA receptors.

9. Pregnenolone biosynthesis in C6-2B glioma cell mitochondria: regulation by a mitochondrial diazepam binding inhibitor receptor.

10. Isolation, characterization, and purification to homogeneity of an endogenous polypeptide with agonistic action on benzodiazepine receptors.

Review 1. Liver fatty acid-binding protein and obesity.

Review 2. Acyl-CoA binding proteins: multiplicity and function.

3. Overexpression of acyl-coA binding protein and its effects on the flux of free fatty acids in McA-RH 7777 cells.

4. Acyl-CoA binding protein gene ablation induces pre-implantation embryonic lethality in mice.

5. Hepatic phenotype of liver fatty acid binding protein gene-ablated mice.