OBJECTIVE: Ageing is accompanied by diminished practice-dependent plasticity. We investigated the effect of age on another plasticity inducing paradigm, repetitive transcranial magnetic stimulation (rTMS). METHODS: Healthy young (n=15; 25+/-4 years) and old (n=15; 67+/-5 years) adults participated in two experiments. Motor evoked potentials (MEPs) were measured in the target muscle (first dorsal interosseus, FDI) and a remote muscle (abductor digiti minimi) during a set of single stimuli. Subjects then received real or sham inhibitory rTMS (intermittent subthreshold trains of 6Hz stimulation for 10min). MEPs were measured for 30min after rTMS. RESULTS: In young adults, MEPs in the target FDI muscle were approximately 15% smaller in the real rTMS experiment than in the sham rTMS experiment (P<0.026). In old adults, FDI MEP size did not differ between experiments. CONCLUSIONS: Advancing age is associated with reduced efficacy of inhibitory rTMS. SIGNIFICANCE: This work has important implications for the potential therapeutic use of rTMS in stroke and neurological disease.
OBJECTIVE: Ageing is accompanied by diminished practice-dependent plasticity. We investigated the effect of age on another plasticity inducing paradigm, repetitive transcranial magnetic stimulation (rTMS). METHODS: Healthy young (n=15; 25+/-4 years) and old (n=15; 67+/-5 years) adults participated in two experiments. Motor evoked potentials (MEPs) were measured in the target muscle (first dorsal interosseus, FDI) and a remote muscle (abductor digiti minimi) during a set of single stimuli. Subjects then received real or sham inhibitory rTMS (intermittent subthreshold trains of 6Hz stimulation for 10min). MEPs were measured for 30min after rTMS. RESULTS: In young adults, MEPs in the target FDI muscle were approximately 15% smaller in the real rTMS experiment than in the sham rTMS experiment (P<0.026). In old adults, FDI MEP size did not differ between experiments. CONCLUSIONS: Advancing age is associated with reduced efficacy of inhibitory rTMS. SIGNIFICANCE: This work has important implications for the potential therapeutic use of rTMS in stroke and neurological disease.
Authors: Alison Mary; Vincent Wens; Marc Op de Beeck; Rachel Leproult; Xavier De Tiège; Philippe Peigneux Journal: Hum Brain Mapp Date: 2016-10-11 Impact factor: 5.038
Authors: Kelly A Tennant; DeAnna L Adkins; Matthew D Scalco; Nicole A Donlan; Aaron L Asay; Nagheme Thomas; Jeffrey A Kleim; Theresa A Jones Journal: Neurobiol Learn Mem Date: 2012-09-23 Impact factor: 2.877
Authors: Paulo E P Teixeira; Kevin Pacheco-Barrios; Muhammed Enes Gunduz; Anna Carolyna Gianlorenço; Luis Castelo-Branco; Felipe Fregni Journal: Neurophysiol Clin Date: 2021-02-26 Impact factor: 3.734