Literature DB >> 200700

Recovery of avian sarcoma virus from tumors induced by transformation-defective mutants.

H Hanafusa, C C Halpern, D L Buchhagen, S Kawai.   

Abstract

Transformation-defective (td) mutants of the Schmidt-Ruppin strain of Rous sarcoma virus (RSV), which contains deletions in the gene responsible for transformation (src gene), are unable to transform chicken embryo fibroblasts in vitro. Injection of some of these td mutants into newborn chickens resulted in the formation of sarcomas from which sarcoma virus was unfailingly recovered. The possibility that transforming RSV was present in the td virus preparations was excluded by further purification of the td viruses. Morphology of the foci induced by the newly recovered sarcoma virus was distinct from that of foci induced by the parental Schmidt Ruppin strain of RSV. It is suggested that the new sarcoma virus was generated as a result of the genetic interaction between the genomes of td virus and chicken cells.

Entities:  

Mesh：

Substances：

Year:  1977        PMID： 200700      PMCID： PMC2181894          DOI： 10.1084/jem.146.6.1735

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  36 in total

1.  Recombination between endogenous and exogenous RNA tumor virus genes as analyzed by nucleic acid hybridization.

Authors:  W S Hayward; H Hanafusa
Journal:  J Virol       Date:  1975-06       Impact factor: 5.103

2.  35S a and b RNA subunits of avian RNA tumor virus strains cloned and passaged in chick and duck cells.

Authors:  M P Stone; R E Smith; W K Joklik
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1975

3.  DNA related to the transforming gene(s) of avian sarcoma viruses is present in normal avian DNA.

Authors:  D Stehelin; H E Varmus; J M Bishop; P K Vogt
Journal:  Nature       Date:  1976-03-11       Impact factor: 49.962

4.  Purification of DNA complementary to nucleotide sequences required for neoplastic transformation of fibroblasts by avian sarcoma viruses.

Authors:  D Stehelin; R V Guntaka; H E Varmus; J M Bishop
Journal:  J Mol Biol       Date:  1976-03-05       Impact factor: 5.469

5.  Rat sequences of the Kirsten and Harvey murine sarcoma virus genomes: nature, origin, and expression in rat tumor RNA.

Authors:  G R Anderson; K C Robbins
Journal:  J Virol       Date:  1976-02       Impact factor: 5.103

6.  Mapping RNase T1-resistant oligonucleotides of avian tumor virus RNAs: sarcoma-specific oligonucleotides are near the poly(A) end and oligonucleotides common to sarcoma and transformation-defective viruses are at the poly(A) end.

Authors:  L H Wang; P Duesberg; K Beemon; P K Vogt
Journal:  J Virol       Date:  1975-10       Impact factor: 5.103

7.  Derivation of mouse sarcoma virus (Kirsten) by acquisition of genes from heterologous host.

Authors:  P Roy-Burman; V Klement
Journal:  J Gen Virol       Date:  1975-08       Impact factor: 3.891

8.  Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range.

Authors:  R H Joho; M A Billeter; C Weissmann
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

9.  Separation of sarcoma virus-specific and leukemia virus-specific genetic sequences of Moloney sarcoma virus.

Authors:  E M Scolnick; R S Howk; A Anisowicz; P T Peebles; C D Scher; W P Parks
Journal:  Proc Natl Acad Sci U S A       Date:  1975-11       Impact factor: 11.205

10.  Location of envelope-specific and sarcoma-specific oligonucleotides on RNA of Schmidt-Ruppin Rous sarcoma virus.

Authors:  L H Wang; P H Duesberg; S Kawai; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1976-02       Impact factor: 11.205
View more
  65 in total

1.  Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

Authors:  H Oppermann; A D Levinson; H E Varmus; L Levintow; J M Bishop
Journal:  Proc Natl Acad Sci U S A       Date:  1979-04       Impact factor: 11.205

2.  Carboxyl-terminal determinants of Abelson protein important for lymphoma induction.

Authors:  K Parmar; R C Huebner; N Rosenberg
Journal:  J Virol       Date:  1991-12       Impact factor: 5.103

3.  Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene.

Authors:  H Iba; R Jove; H Hanafusa
Journal:  Mol Cell Biol       Date:  1985-10       Impact factor: 4.272

4.  In vitro isolation of stable rat sarcoma viruses.

Authors:  S Rasheed; M B Gardner; R J Huebner
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

5.  Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src.

Authors:  H Iba; F R Cross; E A Garber; H Hanafusa
Journal:  Mol Cell Biol       Date:  1985-05       Impact factor: 4.272

6.  Homologous recombination between a defective virus and a chromosomal sequence in mammalian cells.

Authors:  Y Shaul; O Laub; M D Walker; W J Rutter
Journal:  Proc Natl Acad Sci U S A       Date:  1985-06       Impact factor: 11.205

7.  Recombination between a defective retrovirus and homologous sequences in host DNA: reversion by patch repair.

Authors:  P Schwartzberg; J Colicelli; S P Goff
Journal:  J Virol       Date:  1985-03       Impact factor: 5.103

8.  NH2-terminal sequences of two src proteins that cause aberrant transformation.

Authors:  E A Garber; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1987-01       Impact factor: 11.205

9.  Induction of tumors and generation of recovered sarcoma viruses by, and mapping of deletions in, two molecularly cloned src deletion mutants.

Authors:  L H Wang; B Edelstein; B J Mayer
Journal:  J Virol       Date:  1984-06       Impact factor: 5.103

10.  Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

Authors:  H Iba; T Takeya; F R Cross; T Hanafusa; H Hanafusa
Journal:  Proc Natl Acad Sci U S A       Date:  1984-07       Impact factor: 11.205
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.