Literature DB >> 2983084

Recombination between a defective retrovirus and homologous sequences in host DNA: reversion by patch repair.

P Schwartzberg, J Colicelli, S P Goff.   

Abstract

The genomes of mammalian species contain multiple copies of sequences homologous to exogenous retroviruses. When a mutant retrovirus carrying a lethal deletion in an essential viral gene was introduced into mammalian cells, revertant viruses appeared and spread throughout the culture. Analysis of one such revertant showed that the mutation had been repaired by homologous recombination with endogenous sequences. Our results suggest that defective retroviruses can draw upon the genetic complement of the host cell to repair lesions in viral genes.

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Year:  1985        PMID： 2983084      PMCID： PMC254699     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  50 in total

1.  Genetic recombination among temperature-sensitive mutnats of Rous sarcoma virus.

Authors:  J A Wyke; J G Bell; J A Beamand
Journal:  Cold Spring Harb Symp Quant Biol       Date:  1975

2.  Detection of specific sequences among DNA fragments separated by gel electrophoresis.

Authors:  E M Southern
Journal:  J Mol Biol       Date:  1975-11-05       Impact factor: 5.469

3.  Genetic recombinants and heterozygotes derived from endogenous and exogenous avian RNA tumor viruses.

Authors:  R A Weiss; W S Mason; P K Vogt
Journal:  Virology       Date:  1973-04       Impact factor: 3.616

4.  Studies of the mechanism of induction of infectious murine leukemia virus from AKR mouse embryo cell lines by 5-iododeoxyuridine and 5-bromodeoxyuridine.

Authors:  N Teich; D R Lowy; J W Hartley; W P Rowe
Journal:  Virology       Date:  1973-01       Impact factor: 3.616

5.  Selective extraction of polyoma DNA from infected mouse cell cultures.

Authors:  B Hirt
Journal:  J Mol Biol       Date:  1967-06-14       Impact factor: 5.469

6.  Characterization of murine leukaemia virus-specific DNA present in normal mouse cells.

Authors:  L D Gelb; J B Milstien; M A Martin; S A Aaronson
Journal:  Nat New Biol       Date:  1973-07-18

7.  A novel murine oncornavirus with dual eco- and xenotropic properties.

Authors:  P J Fischinger; S Nomura; D P Bolognesi
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

8.  Definitive evidence that the murine C-type virus inducing locus Akv-1 is viral genetic material.

Authors:  S K Chattopadhyay; W P Rowe; N M Teich; D R Lowy
Journal:  Proc Natl Acad Sci U S A       Date:  1975-03       Impact factor: 11.205

9.  Construction and analysis of deletion mutations in the pol gene of Moloney murine leukemia virus: a new viral function required for productive infection.

Authors:  P Schwartzberg; J Colicelli; S P Goff
Journal:  Cell       Date:  1984-07       Impact factor: 41.582

10.  Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells.

Authors:  S A Aaronson; G J Todaro; E M Scolnick
Journal:  Science       Date:  1971-10-08       Impact factor: 47.728
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  18 in total

1.  Genomic stability of murine leukemia viruses containing insertions at the Env-3' untranslated region boundary.

Authors:  C R Logg; A Logg; C K Tai; P M Cannon; N Kasahara
Journal:  J Virol       Date:  2001-08       Impact factor: 5.103

2.  A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology.

Authors:  F Clavel; J M Orenstein
Journal:  J Virol       Date:  1990-10       Impact factor: 5.103

3.  Isolation of a recombinant murine leukemia virus utilizing a new primer tRNA.

Authors:  J Colicelli; S P Goff
Journal:  J Virol       Date:  1986-01       Impact factor: 5.103

4.  Recombination in the 5' leader of murine leukemia virus is accurate and influenced by sequence identity with a strong bias toward the kissing-loop dimerization region.

Authors:  J G Mikkelsen; A H Lund; M Duch; F S Pedersen
Journal:  J Virol       Date:  1998-09       Impact factor: 5.103

5.  Extended minus-strand DNA as template for R-U5-mediated second-strand transfer in recombinational rescue of primer binding site-modified retroviral vectors.

Authors:  J G Mikkelsen; A H Lund; K Dybkaer; M Duch; F S Pedersen
Journal:  J Virol       Date:  1998-03       Impact factor: 5.103

6.  Truncated gag products encoded by Gv-1-responsive endogenous retrovirus loci.

Authors:  P F Policastro; M Fredholm; M C Wilson
Journal:  J Virol       Date:  1989-10       Impact factor: 5.103

7.  Deletion of a short, untranslated region adjacent to the polypurine tract in Moloney murine leukemia virus leads to formation of aberrant 5' plus-strand DNA ends in vivo.

Authors:  E Bacharach; J Gonsky; D Lim; S P Goff
Journal:  J Virol       Date:  2000-05       Impact factor: 5.103

8.  A C-terminal domain in the avian sarcoma-leukosis virus pol gene product is not essential for viral replication.

Authors:  R A Katz; A M Skalka
Journal:  J Virol       Date:  1988-02       Impact factor: 5.103

9.  Transduction of proto-src sequences in tissue culture by a molecular clone of transformation-defective Rous sarcoma virus with an internal src deletion.

Authors:  W Phares
Journal:  J Virol       Date:  1988-12       Impact factor: 5.103

10.  Effects of 3' untranslated region mutations on plus-strand priming during moloney murine leukemia virus replication.

Authors:  N D Robson; A Telesnitsky
Journal:  J Virol       Date:  1999-02       Impact factor: 5.103
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