Literature DB >> 20069611

Multifaceted activity of HIV Vpr/Vpx proteins: the current view of their virological functions.

Mikako Fujita1, Masami Otsuka, Masako Nomaguchi, Akio Adachi.   

Abstract

Primate immunodeficiency viruses encode viral proteins that are uniquely auxiliary to their growth in host cells. Of these accessory proteins, those designated Vpr and Vpx are least well understood with respect to their functions in the viral replication cycle. Moreover, their assigned roles based on the results in published studies remain controversial. This review summarises current knowledge on human immunodeficiency virus (HIV) Vpr/Vpx proteins, and discusses their functional activities during the viral life cycle in macrophages and T lymphocytes, the two major target cells of HIV infection. (c) 2010 John Wiley & Sons, Ltd.

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Year:  2010        PMID： 20069611     DOI： 10.1002/rmv.636

Source DB:  PubMed          Journal:  Rev Med Virol        ISSN： 1052-9276            Impact factor:   6.989


  13 in total

Review 1.  The functions of the HIV1 protein Vpr and its action through the DCAF1.DDB1.Cullin4 ubiquitin ligase.

Authors:  Laurieann Casey; Xiaoyun Wen; Carlos M C de Noronha
Journal:  Cytokine       Date:  2010-03-27       Impact factor: 3.861

Review 2.  HIV accessory proteins versus host restriction factors.

Authors:  Klaus Strebel
Journal:  Curr Opin Virol       Date:  2013-11-15       Impact factor: 7.090

Review 3.  How SAMHD1 changes our view of viral restriction.

Authors:  Nadine Laguette; Monsef Benkirane
Journal:  Trends Immunol       Date:  2011-12-15       Impact factor: 16.687

4.  The Fourth Major Restriction Factor Against HIV/SIV.

Authors:  Masako Nomaguchi; Mikako Fujita; Akio Adachi
Journal:  Front Microbiol       Date:  2011-06-10       Impact factor: 5.640

5.  SAMHD1-deficient CD14+ cells from individuals with Aicardi-Goutières syndrome are highly susceptible to HIV-1 infection.

Authors:  André Berger; Andreas F R Sommer; Jenny Zwarg; Matthias Hamdorf; Karin Welzel; Nicole Esly; Sylvia Panitz; Andreas Reuter; Irene Ramos; Asavari Jatiani; Lubbertus C F Mulder; Ana Fernandez-Sesma; Frank Rutsch; Viviana Simon; Renate König; Egbert Flory
Journal:  PLoS Pathog       Date:  2011-12-08       Impact factor: 6.823

6.  Expression Profiles of Vpx/Vpr Proteins Are Co-related with the Primate Lentiviral Lineage.

Authors:  Yosuke Sakai; Ariko Miyake; Naoya Doi; Hikari Sasada; Yasuyuki Miyazaki; Akio Adachi; Masako Nomaguchi
Journal:  Front Microbiol       Date:  2016-08-03       Impact factor: 5.640

7.  Phylogenetic Insights into the Functional Relationship between Primate Lentiviral Reverse Transcriptase and Accessory Proteins Vpx/Vpr.

Authors:  Yosuke Sakai; Naoya Doi; Yasuyuki Miyazaki; Akio Adachi; Masako Nomaguchi
Journal:  Front Microbiol       Date:  2016-10-18       Impact factor: 5.640

8.  SAMHD1-Dependent and -Independent Functions of HIV-2/SIV Vpx Protein.

Authors:  Mikako Fujita; Masako Nomaguchi; Akio Adachi; Masami Otsuka
Journal:  Front Microbiol       Date:  2012-08-10       Impact factor: 5.640

9.  Species tropism of HIV-1 modulated by viral accessory proteins.

Authors:  Masako Nomaguchi; Naoya Doi; Yui Matsumoto; Yosuke Sakai; Sachi Fujiwara; Akio Adachi
Journal:  Front Microbiol       Date:  2012-07-26       Impact factor: 5.640

10.  Role of poly-proline motif in HIV-2 Vpx expression.

Authors:  Ariko Miyake; Yasuyuki Miyazaki; Mikako Fujita; Masako Nomaguchi; Akio Adachi
Journal:  Front Microbiol       Date:  2014-01-28       Impact factor: 5.640
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