Literature DB >> 20068164

The high mobility group A1 gene: transforming inflammatory signals into cancer?

Linda M S Resar1.   

Abstract

High mobility group A1 (HMGA1) is highly expressed during embryogenesis and in poorly differentiated cancers, and high levels portend a poor prognosis in some tumors. HMGA1 induces oncogenic transformation in cultured cells and causes aggressive cancers in transgenic mice, whereas blocking it interferes with transformation in experimental models. These findings suggest a pivotal role for HMGA1 in cancer. This review focuses on two recently described HMGA1 transcriptional targets that mediate inflammatory signals and drive malignant transformation because they could serve as biomarkers or therapeutic targets. Further elucidation of HMGA1 function in transformation promises to have a major impact on our war on cancer.

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Year:  2010        PMID： 20068164      PMCID： PMC2807996          DOI： 10.1158/0008-5472.CAN-09-1212

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  22 in total

1.  Prediction of central nervous system embryonal tumour outcome based on gene expression.

Authors:  Scott L Pomeroy; Pablo Tamayo; Michelle Gaasenbeek; Lisa M Sturla; Michael Angelo; Margaret E McLaughlin; John Y H Kim; Liliana C Goumnerova; Peter M Black; Ching Lau; Jeffrey C Allen; David Zagzag; James M Olson; Tom Curran; Cynthia Wetmore; Jaclyn A Biegel; Tomaso Poggio; Shayan Mukherjee; Ryan Rifkin; Andrea Califano; Gustavo Stolovitzky; David N Louis; Jill P Mesirov; Eric S Lander; Todd R Golub
Journal:  Nature       Date:  2002-01-24       Impact factor: 49.962

2.  Complete murine cDNA sequence, genomic structure, and tissue expression of the high mobility group protein HMG-I(Y).

Authors:  K R Johnson; D A Lehn; T S Elton; P J Barr; R Reeves
Journal:  J Biol Chem       Date:  1988-12-05       Impact factor: 5.157

3.  On the presence of two new high mobility group-like proteins in HeLa S3 cells.

Authors:  T Lund; J Holtlund; M Fredriksen; S G Laland
Journal:  FEBS Lett       Date:  1983-02-21       Impact factor: 4.124

4.  Architectural transcription factor HMGI(Y) promotes tumor progression and mesenchymal transition of human epithelial cells.

Authors:  R Reeves; D D Edberg; Y Li
Journal:  Mol Cell Biol       Date:  2001-01       Impact factor: 4.272

5.  The oncogenic properties of the HMG-I gene family.

Authors:  L J Wood; J F Maher; T E Bunton; L M Resar
Journal:  Cancer Res       Date:  2000-08-01       Impact factor: 12.701

6.  Adenovirus-mediated suppression of HMGI(Y) protein synthesis as potential therapy of human malignant neoplasias.

Authors:  S Scala; G Portella; M Fedele; G Chiappetta; A Fusco
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-11       Impact factor: 11.205

7.  The high-mobility group A1a/signal transducer and activator of transcription-3 axis: an achilles heel for hematopoietic malignancies?

Authors:  Joelle Hillion; Surajit Dhara; Takita Felder Sumter; Mita Mukherjee; Francescopaolo Di Cello; Amy Belton; James Turkson; Souyma Jaganathan; Linzhao Cheng; Zhaohui Ye; Richard Jove; Peter Aplan; Ying-Wei Lin; Kelsey Wertzler; Ray Reeves; Ossama Elbahlouh; Jeanne Kowalski; Raka Bhattacharya; Linda M S Resar
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

8.  The HMG-I oncogene causes highly penetrant, aggressive lymphoid malignancy in transgenic mice and is overexpressed in human leukemia.

Authors:  Yi Xu; Takita Felder Sumter; Raka Bhattacharya; Abeba Tesfaye; Ephraim J Fuchs; Lisa J Wood; David L Huso; Linda M S Resar
Journal:  Cancer Res       Date:  2004-05-15       Impact factor: 12.701

9.  Growth factor-induced delayed early response genes.

Authors:  A Lanahan; J B Williams; L K Sanders; D Nathans
Journal:  Mol Cell Biol       Date:  1992-09       Impact factor: 4.272

10.  SAR-dependent mobilization of histone H1 by HMG-I/Y in vitro: HMG-I/Y is enriched in H1-depleted chromatin.

Authors:  K Zhao; E Käs; E Gonzalez; U K Laemmli
Journal:  EMBO J       Date:  1993-08       Impact factor: 11.598
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  55 in total

1.  A protein array screen for Kaposi's sarcoma-associated herpesvirus LANA interactors links LANA to TIP60, PP2A activity, and telomere shortening.

Authors:  Meir Shamay; Jianyong Liu; Renfeng Li; Gangling Liao; Li Shen; Melanie Greenway; Shaohui Hu; Jian Zhu; Zhi Xie; Richard F Ambinder; Jiang Qian; Heng Zhu; S Diane Hayward
Journal:  J Virol       Date:  2012-02-29       Impact factor: 5.103

Review 2.  The high mobility group A1 molecular switch: turning on cancer - can we turn it off?

Authors:  Tait H Huso; Linda M S Resar
Journal:  Expert Opin Ther Targets       Date:  2014-03-31       Impact factor: 6.902

Review 3.  Diabetes, Obesity, and Breast Cancer.

Authors:  Chifei Kang; Derek LeRoith; Emily J Gallagher
Journal:  Endocrinology       Date:  2018-11-01       Impact factor: 4.736

4.  AKNA: another AT-hook transcription factor "hooking-up" with inflammation.

Authors:  Alison R Moliterno; Linda M S Resar
Journal:  Cell Res       Date:  2011-06-14       Impact factor: 25.617

5.  IBRUTinib: BRUTe force against bortezomib-resistant myeloma cells.

Authors:  Lingling Xian; Carol Ann Huff; Linda M S Resar
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

6.  Hmga1 deficiency: "SAC-King" the SAC genes to incite chromosomal instability.

Authors:  Lingling Xian; Karen A Reddy; Linda M S Resar
Journal:  Cell Cycle       Date:  2016-12-15       Impact factor: 4.534

7.  Flavopiridol induces BCL-2 expression and represses oncogenic transcription factors in leukemic blasts from adults with refractory acute myeloid leukemia.

Authors:  Dwella M Nelson; Biju Joseph; Joelle Hillion; Jodi Segal; Judith E Karp; Linda M S Resar
Journal:  Leuk Lymphoma       Date:  2011-07-05

8.  Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes.

Authors:  Emmette R Hutchison; Elisa M Kawamoto; Dennis D Taub; Ashish Lal; Kotb Abdelmohsen; Yongqing Zhang; William H Wood; Elin Lehrmann; Simonetta Camandola; Kevin G Becker; Myriam Gorospe; Mark P Mattson
Journal:  Glia       Date:  2013-05-07       Impact factor: 7.452

9.  The High Mobility Group A proteins contribute to thyroid cell transformation by regulating miR-603 and miR-10b expression.

Authors:  Paula Mussnich; Daniela D'Angelo; Vincenza Leone; Carlo Maria Croce; Alfredo Fusco
Journal:  Mol Oncol       Date:  2013-01-17       Impact factor: 6.603

10.  STAT3 inhibitor has potent antitumor activity in B-lineage acute lymphoblastic leukemia cells overexpressing the high mobility group A1 (HMGA1)-STAT3 pathway.

Authors:  Amy Belton; Lingling Xian; Tait Huso; Michael Koo; Li Z Luo; James Turkson; Brent D G Page; Patrick T Gunning; Guosheng Liu; David L Huso; Linda M S Resar
Journal:  Leuk Lymphoma       Date:  2016-03-08
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