Literature DB >> 20068012

Prazosin treatment in the management of scorpion envenomation.

Erdal Peker1, Suleyman Oktar, Murat Dogan, Ergun Kaya, Mehmet Duru.   

Abstract

Scorpion stings represent an important and serious public health problem worldwide due to their high incidence and potentially severe and often fatal clinical manifestations. Children are at greater risk of developing severe cardiac, respiratory, and neurological complications due to lesser body surface area. Alpha receptor stimulation plays important role in the pathogenesis of pulmonary edema. Prazosin, a post synaptic alpha blocker, can be recommended as an effective drug in the treatment of serious scorpion envenomations with significant sympathetic symptoms. Oral prazosin is fast acting, easily available, relatively cheap, free from any anaphylaxis and highly effective.

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Year:  2010        PMID: 20068012     DOI: 10.1177/0960327109359639

Source DB:  PubMed          Journal:  Hum Exp Toxicol        ISSN: 0960-3271            Impact factor:   2.903


  4 in total

1.  Severe Troponin I Elevation and Myocardial Dysfunction in a Child with Scorpion Sting.

Authors:  Nagehan Aslan; Dincer Yildizdas; Ozden Ozgur Horoz; Didar Arslan; Celal Varan; Sevcan Erdem; Hayri Levent Yılmaz
Journal:  J Pediatr Intensive Care       Date:  2018-10-03

2.  Efficacy and safety of scorpion antivenom plus prazosin compared with prazosin alone for venomous scorpion (Mesobuthus tamulus) sting: randomised open label clinical trial.

Authors:  Himmatrao Saluba Bawaskar; Pramodini Himmatrao Bawaskar
Journal:  BMJ       Date:  2011-01-05

3.  Pharmacophore mapping based inhibitor selection and molecular interaction studies for identification of potential drugs on calcium activated potassium channel blockers, tamulotoxin.

Authors:  R Barani Kumar; M Xavier Suresh
Journal:  Pharmacogn Mag       Date:  2013-04       Impact factor: 1.085

4.  Scorpion-related cardiomyopathy and acute pulmonary edema in a child who is stung by Leiurus abdullahbayrami.

Authors:  Mehmet Dokur; Mustafa Dogan; Ersen Aydin Yagmur
Journal:  Turk J Emerg Med       Date:  2017-03-18
  4 in total

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