Literature DB >> 20064720

Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity.

Aranapakam M Venkatesan1, O Dos Santos, John Ellingboe, Deborah A Evrard, Boyd L Harrison, Deborah L Smith, Rosemary Scerni, Geoffrey A Hornby, Lee E Schechter, Terrence H Andree.   

Abstract

Several benzofuran derivatives linked to a 3-indoletetrahydropyridine through an alkyl chain were prepared and evaluated for serotonin transporter and 5-HT(1A) receptor affinities. Their design, synthesis and structure-activity relationships are described. Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID: 20064720     DOI: 10.1016/j.bmcl.2009.12.093

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  5 in total

1.  Classification of 5-HT(1A) receptor agonists and antagonists using GA-SVM method.

Authors:  Xue-lian Zhu; Hai-yan Cai; Zhi-jian Xu; Yong Wang; He-yao Wang; Ao Zhang; Wei-liang Zhu
Journal:  Acta Pharmacol Sin       Date:  2011-10-03       Impact factor: 6.150

2.  Total synthesis of (-)-4-desacetoxy-1-oxovindoline: Single atom exchange of an embedded core heteroatom in vindoline.

Authors:  Byron A Boon; Yi-Yun Yu; Dale L Boger
Journal:  Tetrahedron       Date:  2021-03-29       Impact factor: 2.457

3.  7-(tert-Butyl-diphenyl-sil-yloxy)-2,2-dimethyl-1-benzofuran-3(2H)-one.

Authors:  Cristian O Salas; Ricardo A Tapia; Alejandro Macías
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-12

4.  (5-Benzoyl-2-methyl-4-{[1-(pyridin-4-yl)-1H-1,2,3-triazol-4-yl]meth-oxy}-1-benzofuran-7-yl)(phen-yl)methanone.

Authors:  Xiao-Qin Zhang; Hai-Liang Zhang; Zhu-Yong Dong; Qiang Qian; Yu-Guang Wang
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2012-05-31

5.  Selectivity, Speciation, and Substrate Control in the Gold-Catalyzed Coupling of Indoles and Alkynes.

Authors:  Ryan G Epton; William P Unsworth; Jason M Lynam
Journal:  Organometallics       Date:  2022-02-10       Impact factor: 3.876

  5 in total

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