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Literature DB >> 20064429

Cataloging the Repertoire of Nature's Blowtorch, P450.

Abstract

Veith et al. (2009) analyzed over 17,000 compounds for interaction with the five major human cytochrome P450 drug-metabolizing enzymes. Analysis of the results provides some structural insight and framework for expansion. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year: 2009 PMID： 20064429 DOI： 10.1016/j.chembiol.2009.12.002

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

6 in total

Review 1. Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm.

Authors: F Peter Guengerich; Zhongmei Tang; S Giovanna Salamanca-Pinzón; Qian Cheng
Journal: Mol Interv Date: 2010-06

2. Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediate.

Authors: Harriet L R Cooper; John T Groves
Journal: Arch Biochem Biophys Date: 2010-11-12 Impact factor: 4.013

3. Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.

Authors: Relly Brandman; Jed N Lampe; Yigal Brandman; Paul R Ortiz de Montellano
Journal: Arch Biochem Biophys Date: 2011-02-26 Impact factor: 4.013

Cataloging the Repertoire of Nature's Blowtorch, P450.

Review 1. Characterizing proteins of unknown function: orphan cytochrome p450 enzymes as a paradigm.

2. Molecular probes of the mechanism of cytochrome P450. Oxygen traps a substrate radical intermediate.

3. Active-site residues move independently from the rest of the protein in a 200 ns molecular dynamics simulation of cytochrome P450 CYP119.

4. Human cytochrome P450 17A1 conformational selection: modulation by ligand and cytochrome b5.

Review 5. Recent Structural Insights into Cytochrome P450 Function.

Review 6. Reductive Cytochrome P450 Reactions and Their Potential Role in Bioremediation.