INTRODUCTION AND HYPOTHESIS: We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence. METHODS: The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy. RESULTS: In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased. CONCLUSION: A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.
INTRODUCTION AND HYPOTHESIS: We created a rat model with a retroflexed bladder that mimicked the loss of the posterior urethrovesical angle and compared the results with sham-surgery rats for the establishment of rat models of stress urinary incontinence. METHODS: The retroflexed bladder was created by stitching the bladder posteriorly to the psoas muscle. Sneeze-induced urethral pressure response and urethral baseline pressure were measured using a microtip-transducer catheter and leak point pressures induced by sneezing, the Crede maneuver, and the vertical tilt table method were measured via a supra-pubic cystostomy. RESULTS: In rats with a retroflexed bladder, both urethral pressure response and sneeze-induced leak point pressure were significantly decreased. CONCLUSION: A retroflexed bladder may cause stress urinary incontinence by attenuating the sneeze-induced active urethral closure mechanism. Urethral pressure response restored by resumption of the posterior urethrovesical angle would explain why no sling tension is needed to treat the stress urinary incontinence.
Authors: Izumi Kamo; Kazumasa Torimoto; Michael B Chancellor; William C de Groat; Naoki Yoshimura Journal: Am J Physiol Regul Integr Comp Physiol Date: 2003-05-15 Impact factor: 3.619
Authors: Deirdre A Conway; Izumi Kamo; Naoki Yoshimura; Michael B Chancellor; Tracy W Cannon Journal: Int Urogynecol J Pelvic Floor Dysfunct Date: 2005-08-19
Authors: Yasuhiro Kaiho; Izumi Kamo; Michael B Chancellor; Yoichi Arai; William C de Groat; Naoki Yoshimura Journal: Am J Physiol Renal Physiol Date: 2006-10-17