Elena Lazzeri1, Benedetta Mazzinghi, Paola Romagnani. 1. Excellence Centre for Research, Transfer and High Education for the Development of DE NOVO Therapies (DENOTHE), University of Florence, Florence, Italy.
Abstract
PURPOSE OF REVIEW: Following any injury, various intracellular and intercellular pathways must be activated and coordinated if tissue integrity and homeostasis need to be restored. In most injuries, repair results in once-functional tissue becoming a patch of cells and disorganized extracellular matrix that is referred to as a scar. However, most adult organs of the body, including the kidney, have the potential to regenerate functional tissues if appropriate conditions are restored. In this review, we highlight the burst of recent knowledge leading to discovery of regenerative mechanisms also in adult kidneys. RECENT FINDINGS: A large body of evidence has recently shown that the parietal epithelium of the Bowman's capsule represents a reservoir of renal progenitors in adult kidney. SUMMARY: The discovery of a hierarchical population of renal progenitors within the Bowman's capsule which can generate novel podocytes and also proximal tubular cells provides a new point of view for the understanding of renal physiology. In addition, the observation that renal progenitors can also generate hyperplastic glomerular lesions opens up a novel view of the pathogenesis of different types of glomerular disorders, which may at least in part result from abnormal regenerative responses to podocyte injury.
PURPOSE OF REVIEW: Following any injury, various intracellular and intercellular pathways must be activated and coordinated if tissue integrity and homeostasis need to be restored. In most injuries, repair results in once-functional tissue becoming a patch of cells and disorganized extracellular matrix that is referred to as a scar. However, most adult organs of the body, including the kidney, have the potential to regenerate functional tissues if appropriate conditions are restored. In this review, we highlight the burst of recent knowledge leading to discovery of regenerative mechanisms also in adult kidneys. RECENT FINDINGS: A large body of evidence has recently shown that the parietal epithelium of the Bowman's capsule represents a reservoir of renal progenitors in adult kidney. SUMMARY: The discovery of a hierarchical population of renal progenitors within the Bowman's capsule which can generate novel podocytes and also proximal tubular cells provides a new point of view for the understanding of renal physiology. In addition, the observation that renal progenitors can also generate hyperplastic glomerular lesions opens up a novel view of the pathogenesis of different types of glomerular disorders, which may at least in part result from abnormal regenerative responses to podocyte injury.
Authors: Ivica Grgic; Craig R Brooks; Andreas F Hofmeister; Vanesa Bijol; Joseph V Bonventre; Benjamin D Humphreys Journal: J Am Soc Nephrol Date: 2012-02-23 Impact factor: 10.121
Authors: Liliya M Yamaleyeva; Nadia K Guimaraes-Souza; Louis S Krane; Sigrid Agcaoili; Kenneth Gyabaah; Anthony Atala; Tamer Aboushwareb; James J Yoo Journal: Stem Cells Transl Med Date: 2012-05-03 Impact factor: 6.940
Authors: Agnieszka A Pozdzik; Laetitia Giordano; Gang Li; Marie-Hélène Antoine; Nathalie Quellard; Julie Godet; Eric De Prez; Cécile Husson; Anne-Emilie Declèves; Volker M Arlt; Jean-Michel Goujon; Isabelle Brochériou-Spelle; Steven R Ledbetter; Nathalie Caron; Joëlle L Nortier Journal: PLoS One Date: 2016-07-05 Impact factor: 3.240