| Literature DB >> 20061022 |
Agnieszka Pluta1, Agata Wrzesien-Kus, Barbara Cebula-Obrzut, Anna Wolska, Anna Szmigielska-Kaplon, Magdalena Czemerska, Piotr Pluta, Tadeusz Robak, Piotr Smolewski, Agnieszka Wierzbowska.
Abstract
The role of the Smac/DIABLO protein, a novel apoptosis agonist, in acute myeloid leukemia (AML) is not clearly determined. The expression of Smac/DIABLO protein in AML leukemic cells and its relationship with clinical outcome was evaluated in this study. The intracellular expression of Smac/DIABLO protein was assessed using multi-color flow cytometry in 71 newly diagnosed AML patients treated with conventional chemotherapy. It was found that the high expression of Smac/DIABLO protein was an independent prognostic factor in terms of higher complete remission rate (p<0.001) and longer overall survival (p=0.003). Moreover the low expression of Smac/DIABLO protein was associated with poor karyotype. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20061022 DOI： 10.1016/j.leukres.2009.11.030
Source DB: PubMed Journal: Leuk Res ISSN： 0145-2126 Impact factor: 3.156