Literature DB >> 22293567

Targeting IAP proteins for therapeutic intervention in cancer.

Simone Fulda1, Domagoj Vucic.   

Abstract

Evasion of apoptosis is one of the crucial acquired capabilities used by cancer cells to fend off anticancer therapies. Inhibitor of apoptosis (IAP) proteins exert a range of biological activities that promote cancer cell survival and proliferation. X chromosome-linked IAP is a direct inhibitor of caspases - pro-apoptotic executioner proteases - whereas cellular IAP proteins block the assembly of pro-apoptotic protein signalling complexes and mediate the expression of anti-apoptotic molecules. Furthermore, mutations, amplifications and chromosomal translocations of IAP genes are associated with various malignancies. Among the therapeutic strategies that have been designed to target IAP proteins, the most widely used approach is based on mimicking the IAP-binding motif of second mitochondria-derived activator of caspase (SMAC), which functions as an endogenous IAP antagonist. Alternative strategies include transcriptional repression and the use of antisense oligonucleotides. This Review provides an update on IAP protein biology as well as current and future perspectives on targeting IAP proteins for therapeutic intervention in human malignancies.

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Year:  2012        PMID： 22293567     DOI： 10.1038/nrd3627

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  232 in total

1.  NMR structure and mutagenesis of the inhibitor-of-apoptosis protein XIAP.

Authors:  C Sun; M Cai; A H Gunasekera; R P Meadows; H Wang; J Chen; H Zhang; W Wu; N Xu; S C Ng; S W Fesik
Journal:  Nature       Date:  1999-10-21       Impact factor: 49.962

2.  Smac mimetic increases chemotherapy response and improves survival in mice with pancreatic cancer.

Authors:  Sean P Dineen; Christina L Roland; Rachel Greer; Juliet G Carbon; Jason E Toombs; Puja Gupta; Nabeel Bardeesy; Haizhou Sun; Noelle Williams; John D Minna; Rolf A Brekken
Journal:  Cancer Res       Date:  2010-03-23       Impact factor: 12.701

3.  Inhibitor of apoptosis proteins physically interact with and block apoptosis induced by Drosophila proteins HID and GRIM.

Authors:  D Vucic; W J Kaiser; L K Miller
Journal:  Mol Cell Biol       Date:  1998-06       Impact factor: 4.272

4.  Cellular inhibitors of apoptosis are global regulators of NF-κB and MAPK activation by members of the TNF family of receptors.

Authors:  Eugene Varfolomeev; Tatiana Goncharov; Heather Maecker; Kerry Zobel; László G Kömüves; Kurt Deshayes; Domagoj Vucic
Journal:  Sci Signal       Date:  2012-03-20       Impact factor: 8.192

5.  Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins.

Authors:  A M Verhagen; P G Ekert; M Pakusch; J Silke; L M Connolly; G E Reid; R L Moritz; R J Simpson; D L Vaux
Journal:  Cell       Date:  2000-07-07       Impact factor: 41.582

6.  Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias.

Authors:  I Tamm; S M Kornblau; H Segall; S Krajewski; K Welsh; S Kitada; D A Scudiero; G Tudor; Y H Qui; A Monks; M Andreeff; J C Reed
Journal:  Clin Cancer Res       Date:  2000-05       Impact factor: 12.531

7.  Engineering ML-IAP to produce an extraordinarily potent caspase 9 inhibitor: implications for Smac-dependent anti-apoptotic activity of ML-IAP.

Authors:  Domagoj Vucic; Matthew C Franklin; Heidi J A Wallweber; Kanad Das; Brendan P Eckelman; Hwain Shin; Linda O Elliott; Saloumeh Kadkhodayan; Kurt Deshayes; Guy S Salvesen; Wayne J Fairbrother
Journal:  Biochem J       Date:  2005-01-01       Impact factor: 3.857

8.  Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma.

Authors:  Christina M Annunziata; R Eric Davis; Yulia Demchenko; William Bellamy; Ana Gabrea; Fenghuang Zhan; Georg Lenz; Ichiro Hanamura; George Wright; Wenming Xiao; Sandeep Dave; Elaine M Hurt; Bruce Tan; Hong Zhao; Owen Stephens; Madhumita Santra; David R Williams; Lenny Dang; Bart Barlogie; John D Shaughnessy; W Michael Kuehl; Louis M Staudt
Journal:  Cancer Cell       Date:  2007-08       Impact factor: 31.743

9.  Induction of apoptosis in tumor cells by siRNA-mediated silencing of the livin/ML-IAP/KIAP gene.

Authors:  Irena Crnkovic-Mertens; Felix Hoppe-Seyler; Karin Butz
Journal:  Oncogene       Date:  2003-11-13       Impact factor: 9.867

10.  Structure-based design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site.

Authors:  Haiying Sun; Zaneta Nikolovska-Coleska; Chao-Yie Yang; Liang Xu; York Tomita; Krzysztof Krajewski; Peter P Roller; Shaomeng Wang
Journal:  J Med Chem       Date:  2004-08-12       Impact factor: 7.446
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  317 in total

1.  A Triple-Parameter-Based Laboratory-Friendly Fluorescence Imaging to Identify Apoptosis in Live Cells.

Authors:  Pradip De; Jennifer Carlson Aske; Nandini Dey
Journal:  Methods Mol Biol       Date:  2021

2.  Antagonist of cIAP1/2 and XIAP enhances anti-tumor immunity when combined with radiation and PD-1 blockade in a syngeneic model of head and neck cancer.

Authors:  Roy Xiao; Clint T Allen; Linda Tran; Priya Patel; So-Jin Park; Zhong Chen; Carter Van Waes; Nicole C Schmitt
Journal:  Oncoimmunology       Date:  2018-08-01       Impact factor: 8.110

Review 3.  Photoreceptor cell death and rescue in retinal detachment and degenerations.

Authors:  Yusuke Murakami; Shoji Notomi; Toshio Hisatomi; Toru Nakazawa; Tatsuro Ishibashi; Joan W Miller; Demetrios G Vavvas
Journal:  Prog Retin Eye Res       Date:  2013-08-28       Impact factor: 21.198

4.  Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation.

Authors:  Boxiao Ding; Anita Parmigiani; Chen Yang; Andrei V Budanov
Journal:  Cell Cycle       Date:  2015       Impact factor: 4.534

5.  TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration.

Authors:  Masayuki Yamashita; Emmanuelle Passegué
Journal:  Cell Stem Cell       Date:  2019-06-20       Impact factor: 24.633

6.  Dual Antagonist of cIAP/XIAP ASTX660 Sensitizes HPV- and HPV+ Head and Neck Cancers to TNFα, TRAIL, and Radiation Therapy.

Authors:  Roy Xiao; Yi An; Wenda Ye; Adeeb Derakhshan; Hui Cheng; Xinping Yang; Clint Allen; Zhong Chen; Nicole C Schmitt; Carter Van Waes
Journal:  Clin Cancer Res       Date:  2019-07-02       Impact factor: 12.531

Review 7.  The TWEAK-Fn14 system as a potential drug target.

Authors:  Harald Wajant
Journal:  Br J Pharmacol       Date:  2013-10       Impact factor: 8.739

8.  Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.

Authors:  Mitchell Vamos; Kate Welsh; Darren Finlay; Pooi San Lee; Peter D Mace; Scott J Snipas; Monica L Gonzalez; Santhi Reddy Ganji; Robert J Ardecky; Stefan J Riedl; Guy S Salvesen; Kristiina Vuori; John C Reed; Nicholas D P Cosford
Journal:  ACS Chem Biol       Date:  2013-02-05       Impact factor: 5.100

9.  Synergistic targeting of AML stem/progenitor cells with IAP antagonist birinapant and demethylating agents.

Authors:  Bing Z Carter; Po Yee Mak; Duncan H Mak; Yuexi Shi; Yihua Qiu; James M Bogenberger; Hong Mu; Raoul Tibes; Hui Yao; Kevin R Coombes; Rodrigo O Jacamo; Teresa McQueen; Steven M Kornblau; Michael Andreeff
Journal:  J Natl Cancer Inst       Date:  2014-02       Impact factor: 13.506

10.  Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation.

Authors:  Nobumichi Ohoka; Yoko Morita; Katsunori Nagai; Kenichiro Shimokawa; Osamu Ujikawa; Ikuo Fujimori; Masahiro Ito; Youji Hayase; Keiichiro Okuhira; Norihito Shibata; Takayuki Hattori; Tomoya Sameshima; Osamu Sano; Ryokichi Koyama; Yasuhiro Imaeda; Hiroshi Nara; Nobuo Cho; Mikihiko Naito
Journal:  J Biol Chem       Date:  2018-03-15       Impact factor: 5.157
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