OBJECTIVE: To determine the prognostic factors in node-positive patients with early-stage cervical cancer who underwent radical hysterectomy (RH) and to use these factors to stratify patients into risk groups for individualized adjuvant therapy. METHODS: Patients with early-stage cervical cancer who had lymph node metastasis after RH were retrospectively analyzed. RESULTS: Multivariate analysis showed that non-squamous histology, tumor size and parametrial involvement were significantly associated with recurrence-free survival (RFS) and overall survival (OS). Prognostic scores were generated for these factors, and patients were categorized into low- (score 0; n=74), intermediate- (score 1-2; n=100) and high- (score 3-4; n=14) risk groups. Relative to the low-risk group, the probability of cancer recurrence was significantly higher in the high- (OR=10.87, 95% CI=4.22-28.0, P<.001) and intermediate- (OR=3.01, 95% CI=1.37-6.58, P=.006) risk groups. Moreover, the probability of cancer death was significantly higher in the high- (OR=9.88, 95% CI=3.76-25.94, P<.001) and intermediate- (OR=2.49, 95% CI=1.12-5.55, P=.026) risk groups compared with the low-risk group. The rates of pelvic failure and distant recurrence increased with increasing risk. CONCLUSION(S): Node-positive patients were heterogeneous, with different prognoses and recurrence patterns according to clinicopathologic risk factors. Further clinical trials are warranted to develop adjuvant treatment strategies individualized to each risk group. Copyright 2009 Elsevier Inc. All rights reserved.
OBJECTIVE: To determine the prognostic factors in node-positive patients with early-stage cervical cancer who underwent radical hysterectomy (RH) and to use these factors to stratify patients into risk groups for individualized adjuvant therapy. METHODS:Patients with early-stage cervical cancer who had lymph node metastasis after RH were retrospectively analyzed. RESULTS: Multivariate analysis showed that non-squamous histology, tumor size and parametrial involvement were significantly associated with recurrence-free survival (RFS) and overall survival (OS). Prognostic scores were generated for these factors, and patients were categorized into low- (score 0; n=74), intermediate- (score 1-2; n=100) and high- (score 3-4; n=14) risk groups. Relative to the low-risk group, the probability of cancer recurrence was significantly higher in the high- (OR=10.87, 95% CI=4.22-28.0, P<.001) and intermediate- (OR=3.01, 95% CI=1.37-6.58, P=.006) risk groups. Moreover, the probability of cancer death was significantly higher in the high- (OR=9.88, 95% CI=3.76-25.94, P<.001) and intermediate- (OR=2.49, 95% CI=1.12-5.55, P=.026) risk groups compared with the low-risk group. The rates of pelvic failure and distant recurrence increased with increasing risk. CONCLUSION(S): Node-positive patients were heterogeneous, with different prognoses and recurrence patterns according to clinicopathologic risk factors. Further clinical trials are warranted to develop adjuvant treatment strategies individualized to each risk group. Copyright 2009 Elsevier Inc. All rights reserved.
Authors: Koji Matsuo; David J Nusbaum; Hiroko Machida; Yongmei Huang; Varun Khetan; Shinya Matsuzaki; Maximilian Klar; Brendan H Grubbs; Lynda D Roman; Jason D Wright Journal: Am J Obstet Gynecol Date: 2019-10-31 Impact factor: 8.661
Authors: S Y Ryu; M H Kim; B H Nam; T S Lee; E S Song; C Y Park; J W Kim; Y B Kim; H S Ryu; S Y Park; K T Kim; C H Cho; C Lee; S M Kim; B G Kim; D S Bae; Y T Kim; J-H Nam Journal: Br J Cancer Date: 2013-12-19 Impact factor: 7.640
Authors: Lei Li; XiaoYan Song; RuoNan Liu; Nan Li; Ye Zhang; Yan Cheng; HongTu Chao; LiYing Wang Journal: BMC Cancer Date: 2016-07-07 Impact factor: 4.430