| Literature DB >> 20056538 |
Takayoshi Suzuki1, Rikako Tanaka, Shohei Hamada, Hidehiko Nakagawa, Naoki Miyata.
Abstract
To identify novel non-nucleoside DNA methyltransferase (DNMT) inhibitors, we designed and synthesized a series of maleimide derivatives. Among this series, compounds 5-8 were found to be more potent DNMT1 inhibitors than RG108, a DNMT1 inhibitor reported previously by Siedlecki et al. The binding mode analysis of compound 5 is also reported. Copyright (c) 2009 Elsevier Ltd. All rights reserved.Entities:
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Year: 2009 PMID： 20056538 DOI： 10.1016/j.bmcl.2009.12.016
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823