Literature DB >> 24914366

Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments.

Tung On Yau1, Ceen-Ming Tang1, Jun Yu1.   

Abstract

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) comprises nearly 10% of gastric carcinoma cases worldwide. Recently, it was recognised to have unique clinicopathologic characteristics, including male predominance, lower rates of lymph node involvement, and better prognosis. EBVaGC is further characterised by abnormal hypermethylation of tumour suppressor gene promoter regions, causing down-regulation of their expression. In the present review, we critically discuss the role of EBV in gastric carcinogenesis, summarising the role of viral proteins and microRNAs with respect to aberrant methylation in EBVaGC. Given the role of epigenetic dysregulation in tumourigenesis, epigenetic modifiers may represent a novel therapeutic strategy.

Entities:  

Keywords:  Aberrant DNA methylation; Epigenetic dysregulation; Epigenetic therapies; Epstein-Barr virus; Gastric carcinoma

Mesh：

Substances：

Year:  2014        PMID： 24914366      PMCID： PMC4047330          DOI： 10.3748/wjg.v20.i21.6448

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  95 in total

1.  EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency.

Authors:  Kasandra J Riley; Gabrielle S Rabinowitz; Therese A Yario; Joseph M Luna; Robert B Darnell; Joan A Steitz
Journal:  EMBO J       Date:  2012-03-30       Impact factor: 11.598

2.  Silencing and CpG island methylation of GSTP1 is rare in ordinary gastric carcinomas but common in Epstein-Barr virus-associated gastric carcinomas.

Authors:  Jin Kim; Hye Seung Lee; Soo In Bae; You Mie Lee; Woo Ho Kim
Journal:  Anticancer Res       Date:  2005 Nov-Dec       Impact factor: 2.480

3.  Downregulation of microRNA-200 in EBV-associated gastric carcinoma.

Authors:  Aya Shinozaki; Takashi Sakatani; Tetsuo Ushiku; Rumi Hino; Maya Isogai; Shunpei Ishikawa; Hiroshi Uozaki; Kenzo Takada; Masashi Fukayama
Journal:  Cancer Res       Date:  2010-05-18       Impact factor: 12.701

4.  Identification of silencing of nine genes in human gastric cancers.

Authors:  Atsushi Kaneda; Michio Kaminishi; Kazuyoshi Yanagihara; Takashi Sugimura; Toshikazu Ushijima
Journal:  Cancer Res       Date:  2002-11-15       Impact factor: 12.701

5.  Patterns of aberrant DNA hypermethylation in nasopharyngeal carcinoma in Tunisian patients.

Authors:  S Challouf; S Ziadi; R Zaghdoudi; F Ksiaa; R Ben Gacem; M Trimeche
Journal:  Clin Chim Acta       Date:  2012-01-24       Impact factor: 3.786

6.  DNA methylation profiles of gastric carcinoma characterized by quantitative DNA methylation analysis.

Authors:  Gyeong Hoon Kang; Sun Lee; Nam-Yun Cho; Tasha Gandamihardja; Tiffany I Long; Daniel J Weisenberger; Mihaela Campan; Peter W Laird
Journal:  Lab Invest       Date:  2007-12-24       Impact factor: 5.662

7.  Genetic Polymorphisms of CYP2E1, GSTP1, NQO1 and MPO and the Risk of Nasopharyngeal Carcinoma in a Han Chinese Population of Southern China.

Authors:  Xiuchan Guo; Yi Zeng; Hong Deng; Jian Liao; Yuming Zheng; Ji Li; Bailey Kessing; Stephen J O'Brien
Journal:  BMC Res Notes       Date:  2010-07-27

8.  Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells.

Authors:  Madhavi Billam; Michele D Sobolewski; Nancy E Davidson
Journal:  Breast Cancer Res Treat       Date:  2009-05-21       Impact factor: 4.872

9.  Novel cambinol analogs as sirtuin inhibitors: synthesis, biological evaluation, and rationalization of activity.

Authors:  Federico Medda; Rupert J M Russell; Maureen Higgins; Anna R McCarthy; Johanna Campbell; Alexandra M Z Slawin; David P Lane; Sonia Lain; Nicholas J Westwood
Journal:  J Med Chem       Date:  2009-05-14       Impact factor: 7.446

10.  Somatostatin receptor 1, a novel EBV-associated CpG hypermethylated gene, contributes to the pathogenesis of EBV-associated gastric cancer.

Authors:  J Zhao; Q Liang; K-F Cheung; W Kang; Y Dong; R W-M Lung; J H-M Tong; K-F To; J J Y Sung; J Yu
Journal:  Br J Cancer       Date:  2013-05-30       Impact factor: 7.640
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  22 in total

1.  Anti-proliferative role and prognostic implication of miR-141 in gastric cancer.

Authors:  Mingwei Huang; Liucheng Wu; Yuzhou Qin; Zhao Li; Shanshan Luo; Haiquan Qin; Yang Yang; Jiansi Chen
Journal:  Am J Transl Res       Date:  2016-08-15       Impact factor: 4.060

Review 2.  Kinases and therapeutics in pathogen mediated gastric cancer.

Authors:  Charu Sonkar; Nidhi Varshney; Siva Koganti; Hem Chandra Jha
Journal:  Mol Biol Rep       Date:  2022-01-15       Impact factor: 2.316

3.  Transcriptome sequencing of LMP2A-transfected gastric cancer cells identifies potential biomarkers in EBV-associated gastric cancer.

Authors:  Wen Liu; Hua Xiao; Hui Song; Shucai An; Bing Luo
Journal:  Virus Genes       Date:  2022-07-11       Impact factor: 2.198

4.  Dihydroartemisinin suppresses the proliferation of Epstein-Barr virus-associated gastric carcinoma cells via downregulation of latent membrane protein 2A.

Authors:  Wei Gong; Lei Zhang; Hui Yu; Qiang Yu; Wei-Kang Pan; Yin Wang; Xuan-Lin Wu; Qiang Liu
Journal:  Oncol Lett       Date:  2018-06-12       Impact factor: 2.967

Review 5.  Outlooks on Epstein-Barr virus associated gastric cancer.

Authors:  Madiha Naseem; Afsaneh Barzi; Christine Brezden-Masley; Alberto Puccini; Martin D Berger; Ryuma Tokunaga; Francesca Battaglin; Shivani Soni; Michelle McSkane; Wu Zhang; Heinz-Josef Lenz
Journal:  Cancer Treat Rev       Date:  2018-03-31       Impact factor: 12.111

6.  Clinical Significance of p53 Protein Expression, Beta-catenin Expression and HER2 Expression for Epstein-Barr Virus-associated Gastric Cancer.

Authors:  Dong Won Baek; Byung Woog Kang; Soyoon Hwang; Jong Gwang Kim; An Na Seo; Han Ik Bae; Oh Kyoung Kwon; Seung Soo Lee; Ho Young Chung; Wansik Yu
Journal:  Chonnam Med J       Date:  2017-05-25

Review 7.  Status of Epstein-Barr Virus Coinfection with Helicobacter pylori in Gastric Cancer.

Authors:  Shyam Singh; Hem Chandra Jha
Journal:  J Oncol       Date:  2017-03-21       Impact factor: 4.375

Review 8.  Role of Viral miRNAs and Epigenetic Modifications in Epstein-Barr Virus-Associated Gastric Carcinogenesis.

Authors:  Aldo Giudice; Giovanni D'Arena; Anna Crispo; Mario Felice Tecce; Flavia Nocerino; Maria Grimaldi; Emanuela Rotondo; Anna Maria D'Ursi; Mario Scrima; Massimiliano Galdiero; Gennaro Ciliberto; Mario Capunzo; Gianluigi Franci; Antonio Barbieri; Sabrina Bimonte; Maurizio Montella
Journal:  Oxid Med Cell Longev       Date:  2016-02-10       Impact factor: 6.543

9.  microRNA-25 Inhibits Cell Apoptosis of Human Gastric Adenocarcinoma Cell Line AGS via Regulating CCNE1 and MYC.

Authors:  Yong Zhang; Zheng Peng; Yunshan Zhao; Lin Chen
Journal:  Med Sci Monit       Date:  2016-04-27

10.  Viral driven epigenetic events alter the expression of cancer-related genes in Epstein-Barr-virus naturally infected Burkitt lymphoma cell lines.

Authors:  Hector Hernandez-Vargas; Henri Gruffat; Marie Pierre Cros; Audrey Diederichs; Cécilia Sirand; Romina C Vargas-Ayala; Antonin Jay; Geoffroy Durand; Florence Le Calvez-Kelm; Zdenko Herceg; Evelyne Manet; Christopher P Wild; Massimo Tommasino; Rosita Accardi
Journal:  Sci Rep       Date:  2017-07-19       Impact factor: 4.379
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