Literature DB >> 20056418

Design and synthesis of some new quinoline-3-carbohydrazone derivatives as potential antimycobacterial agents.

Sumesh Eswaran1, Airody Vasudeva Adhikari, Nishith K Pal, Imran H Chowdhury.   

Abstract

A series of 26 new quinoline derivatives carrying active pharmacophores has been synthesized and evaluated for their in vitro antituberculosis activity against Mycobacterium tuberculosis H37Rv (MTB), Mycobacterium smegmatis (MC(2)), and Mycobacterium fortuitum following the broth micro dilution assay method. Compounds 13e, 13i, 13k, 14a, 14c, 14i, and 14k exhibited significant minimum inhibition concentrations, when compared with first line drugs isoniazid (INH) and rifampicin (RIF) and could be ideally suited for further modifications to obtain more efficacious compounds in the fight against multi-drug resistant tuberculosis. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 20056418     DOI： 10.1016/j.bmcl.2009.12.045

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Second generation of primaquine ureas and bis-ureas as potential antimycobacterial agents.

Authors:  Kristina Pavić; Zrinka Rajić; Hana Michnová; Josef Jampílek; Ivana Perković; Branka Zorc
Journal:  Mol Divers       Date:  2018-12-06       Impact factor: 2.943

2.  1-[2-(4-Nitrophenyl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetrahydroquinolin-4-yl]pyrrolidin-2-one.

Authors:  Margarita Gutierrez; Luis Astudillo; Luisa Quesada; Iván Brito; Matías López-Rodríguez
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-01-08

3.  1-[2-(4-Nitro-phen-yl)-5-(5-phenyl-1,2-oxazol-3-yl)-1,2,3,4-tetra-hydro-quinolin-4-yl]pyrrolidin-2-one monohydrate.

Authors:  Margarita Gutierrez; Gabriel Vallejos; Carlos Fernández; Alejandro Cárdenas; Iván Brito
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-12-18

4.  Preparation and in vitro bioactivity evaluation of N-heterocyclic-linked dihomooxacalix[4]arene derivatives.

Authors:  Lin An; Jia-Dong Liu; Xian-Na Peng; You-Guang Zheng; Chan Wang; Tong-Hui Huang
Journal:  RSC Adv       Date:  2019-12-13       Impact factor: 4.036

5.  Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety.

Authors:  Mostafa M Ghorab; Mohamed S A El-Gaby; Aiten M Soliman; Mansour S Alsaid; Marwa M Abdel-Aziz; Mahmoud M Elaasser
Journal:  Chem Cent J       Date:  2017-05-19       Impact factor: 4.215

Review 6.  Modifications of quinolones and fluoroquinolones: hybrid compounds and dual-action molecules.

Authors:  Joanna Fedorowicz; Jarosław Sączewski
Journal:  Monatsh Chem       Date:  2018-06-07       Impact factor: 1.451

7.  Synthesis, crystal structure and Hirshfeld surface analysis of 2-chloro-3-[(E)-(2-phenyl-hydrazinyl-idene)meth-yl]quinoline.

Authors:  Soufiane Akhramez; Abderrafia Hafid; Mostafa Khouili; Mohamed Saadi; Lahcen El Ammari; El Mostafa Ketatni
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2019-06-07

8.  Synthesis of some novel 2-(3-cyano -6-(thiophen- 2-yl)-4,4'- bipyridin-2- yloxy)acetohydrazide derivatives: assessment of their cytotoxic activity.

Authors:  Hossa F Al Shareef
Journal:  BMC Chem       Date:  2020-06-02

9.  Synthesis, Characterization and Anti-Cancer Activity of Hydrazide Derivatives Incorporating a Quinoline Moiety.

Authors:  Murat Bingul; Owen Tan; Christopher R Gardner; Selina K Sutton; Greg M Arndt; Glenn M Marshall; Belamy B Cheung; Naresh Kumar; David StC Black
Journal:  Molecules       Date:  2016-07-14       Impact factor: 4.411

10.  Analysis of Approaches to Anti-tuberculosis Compounds.

Authors:  Sara Motamen; Ronald J Quinn
Journal:  ACS Omega       Date:  2020-10-27
  10 in total

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