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Literature DB >> 20054428

Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time?

Abstract

Restoration of cardiovascular function is the ultimate goal of stem cell-based therapy. In principle, cardiovascular stem cells can improve cardiac function via de novo cardiomyogenesis, enhanced myocardial neovascularization, and prevention of post-infarct remodeling. Stem cell transplantation to improve cardiac function has received mixed results in human clinical trials. These early data suggest that a critical reassessment of the scientific basis to stem cell-based therapy is needed in order to bring this highly promising treatment modality to mainstream clinical care.

Entities: Species

Year: 2008 PMID： 20054428 PMCID： PMC2801905 DOI： 10.1016/j.ddstr.2008.12.003

Source DB: PubMed Journal: Drug Discov Today Ther Strateg ISSN： 1740-6773

62 in total

1. Intracoronary delivery of hematopoietic bone marrow stem cells and luminal loss of the infarct-related artery in patients with recent myocardial infarction.

Authors: Samer Mansour; Marc Vanderheyden; Bernard De Bruyne; Bart Vandekerckhove; Leen Delrue; Inge Van Haute; Guy Heyndrickx; Stephane Carlier; Gaston Rodriguez-Granillo; William Wijns; Jozef Bartunek
Journal: J Am Coll Cardiol Date: 2006-03-27 Impact factor: 24.094

2. Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial.

Authors: Gerd P Meyer; Kai C Wollert; Joachim Lotz; Jan Steffens; Peter Lippolt; Stephanie Fichtner; Hartmut Hecker; Arnd Schaefer; Lubomir Arseniev; Bernd Hertenstein; Arnold Ganser; Helmut Drexler
Journal: Circulation Date: 2006-03-06 Impact factor: 29.690

3. Stem cells and drug discovery: the beginning of a new era?

Authors: Lee L Rubin
Journal: Cell Date: 2008-02-22 Impact factor: 41.582

4. Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction.

Authors: Volker Schächinger; Sandra Erbs; Albrecht Elsässer; Werner Haberbosch; Rainer Hambrecht; Hans Hölschermann; Jiangtao Yu; Roberto Corti; Detlef G Mathey; Christian W Hamm; Tim Süselbeck; Birgit Assmus; Torsten Tonn; Stefanie Dimmeler; Andreas M Zeiher
Journal: N Engl J Med Date: 2006-09-21 Impact factor: 91.245

5. Induced pluripotent stem cells generated without viral integration.

Authors: Matthias Stadtfeld; Masaki Nagaya; Jochen Utikal; Gordon Weir; Konrad Hochedlinger
Journal: Science Date: 2008-09-25 Impact factor: 47.728

6. Regenerating functional myocardium: improved performance after skeletal myoblast transplantation.

Authors: D A Taylor; B Z Atkins; P Hungspreugs; T R Jones; M C Reedy; K A Hutcheson; D D Glower; W E Kraus
Journal: Nat Med Date: 1998-08 Impact factor: 53.440

7. Identification of myocardial and vascular precursor cells in human and mouse epicardium.

Authors: Federica Limana; Antonella Zacheo; David Mocini; Antonella Mangoni; Giovanna Borsellino; Adamo Diamantini; Roberta De Mori; Luca Battistini; Elisa Vigna; Massimo Santini; Vincenzo Loiaconi; Giulio Pompilio; Antonia Germani; Maurizio C Capogrossi
Journal: Circ Res Date: 2007-10-18 Impact factor: 17.367

Review 8. Skeletal myoblasts as a therapeutic agent.

Authors: Philippe Menasché
Journal: Prog Cardiovasc Dis Date: 2007 Jul-Aug Impact factor: 8.194

9. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts.

Authors: Charles E Murry; Mark H Soonpaa; Hans Reinecke; Hidehiro Nakajima; Hisako O Nakajima; Michael Rubart; Kishore B S Pasumarthi; Jitka Ismail Virag; Stephen H Bartelmez; Veronica Poppa; Gillian Bradford; Joshua D Dowell; David A Williams; Loren J Field
Journal: Nature Date: 2004-03-21 Impact factor: 49.962