Literature DB >> 20052624

Severe alcohol hand rub overdose inducing coma, watch after H1N1 pandemic.

Matthieu Henry-Lagarrigue1, Magali Charbonnier, Fabrice Bruneel, Stéphane Legriel, Gilles Troche, Hager Ben Mokhtar, Aihem Yehia, Pierre Guezennec, Jacques Merrer, Catherine Palette, Jean-Pierre Bedos.   

Abstract

BACKGROUND: Alcoholic hand rubs (AHRs) have been proven effective in preventing nosocomial infections, and healthcare authorities include AHRs use among quality-of-care criteria. Since the onset of the influenza A (H1N1) pandemic, AHRs have gained considerable popularity among the general public.
METHODS: We report a case of intentional AHRs self-poisoning inducing rapid coma with hyperlactatemia, and a full recovery. The relevant literature was reviewed. To our knowledge, this is the third reported case of intentional AHRs poisoning. 3 patients presented with a picture of acute alcohol intoxication, of variable severity depending on the amount ingested and speed of ingestion.
RESULTS: The blood alcohol level was 414 mg/dl and tests for other drugs were performed 30 min after admission. The blood lactate level increased briefly to 4.8 mmol/l, without renal or hepatic function disturbances. She regained consciousness after 6 h then achieved a full recovery allowing extubation and readmission to the psychiatric ward after 24 h. She reported gulping down the entire contents of the Aniosgel bottle.
CONCLUSION: Whereas overdrinking in social settings (wine and liquor) leads to a gradual increase in blood alcohol levels, AHRs poisoning is usually characterized by a sudden massive alcohol load. The unusual nature of the alcohol source may lead to diagnostic wanderings. AHRs are currently available in bottles that facilitate the ingestion of large amounts. Unit-dose packaging or dispensing might decrease the risk of AHRs poisoning.

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Year:  2010        PMID: 20052624     DOI: 10.1007/s12028-009-9319-4

Source DB:  PubMed          Journal:  Neurocrit Care        ISSN: 1541-6933            Impact factor:   3.210


  4 in total

1.  An unusual complication of hand hygiene.

Authors:  H S Roberts; R J Self; M Coxon
Journal:  Anaesthesia       Date:  2005-01       Impact factor: 6.955

2.  A surprising side effect of hand antisepsis.

Authors:  Pascal Meyer; Jean-Luc Baudel; Eric Maury; Georges Offenstadt
Journal:  Intensive Care Med       Date:  2005-09-27       Impact factor: 17.440

3.  Novel H1N1 influenza and respiratory protection for health care workers.

Authors:  Kenneth I Shine; Bonnie Rogers; Lewis R Goldfrank
Journal:  N Engl J Med       Date:  2009-09-30       Impact factor: 91.245

4.  Propylene glycol monomethyl ether (PGME): inhalation toxicity and carcinogenicity in Fischer 344 rats and B6C3F1 mice.

Authors:  Pamela J Spencer; James W Crissman; William T Stott; Richard A Corley; Frank S Cieszlak; Alan M Schumann; Jerry F Hardisty
Journal:  Toxicol Pathol       Date:  2002 Sep-Oct       Impact factor: 1.902

  4 in total
  4 in total

1.  Poisoning with Ethanol and 2-Propanol-Based Hand Rubs: Give Caesar What Belongs to Caesar!

Authors:  Bruno Mégarbane; Antoine Villa
Journal:  Neurocrit Care       Date:  2019-02       Impact factor: 3.210

Review 2.  The rising incidence of intentional ingestion of ethanol-containing hand sanitizers.

Authors:  Nicole J Gormley; Alvin C Bronstein; Joseph J Rasimas; Maryland Pao; Angela T Wratney; Junfeng Sun; Howard A Austin; Anthony F Suffredini
Journal:  Crit Care Med       Date:  2012-01       Impact factor: 7.598

3.  A retrospective review of calls to the Poisons Information Helpline of the Western Cape during the first 6 months of the COVID-19 pandemic in South Africa.

Authors:  Catharina E du Plessis; Farah Mohamed; Cindy R Stephen; Helmuth Reuter; Gonwayne Voigt; Daniel J van Hoving; Carine J Marks
Journal:  S Afr J Infect Dis       Date:  2022-03-30

4.  Putatively lethal ingestion of isopropyl alcohol-related case: interpretation of post mortem isopropyl alcohol and acetone concentrations remains challenging.

Authors:  Carine Dumollard; Jean-François Wiart; Florian Hakim; Christophe Demarly; Philippe Morbidelli; Delphine Allorge; Jean-Michel Gaulier
Journal:  Int J Legal Med       Date:  2020-10-22       Impact factor: 2.686

  4 in total

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