| Literature DB >> 20050820 |
Andrew Rundle1, John Richie, Karen Steindorf, Marco Peluso, Kim Overvad, Ole Raaschou-Nielsen, Francoise Clavel-Chapelon, Jacob P Linseisen, Heiner Boeing, Antonia Trichopoulou, Domenico Palli, Vittorio Krogh, Rosario Tumino, Salvatore Panico, Hendrik B Bueno-De-Mesquita, Petra H Peeters, Eiliv Lund, Carlos A Gonzalez, Carmen Martinez, Miren Dorronsoro, Aurelio Barricarte, M Jose Tormo, Josèr Quiros, Antonio Agudo, Goran Berglund, Bengt Jarvholm, Sheila Bingham, Timothy J Key, Emmanuelle Gormally, Rodolfo Saracci, Rudolf Kaaks, Elio Riboli, Paolo Vineis.
Abstract
The association between physical activity, potential intermediate biomarkers and lung cancer risk was investigated in a study of 230 cases and 648 controls nested within the European Prospective Investigation of Cancer and Nutrition. Data on white blood cell aromatic-DNA adducts by (32)P-post-labelling and glutathione (GSH) in red blood cells were available from a subset of cases and controls. Compared with the first quartile, the fourth quartile of recreational physical activity was associated with a lower lung cancer risk (odds ratio (OR) 0.56, 95% confidence interval (CI) 0.35-0.90), higher GSH levels (+1.87 micromol GSH g(-1) haemoglobin, p = 0.04) but not with the presence of high levels of adducts (OR 1.05, 95% CI 0.38-2.86). Despite being associated with recreational physical activity, in these small-scale pilot analyses GSH levels were not associated with lung cancer risk (OR 0.95, 95% CI 0.84-1.07 per unit increase in GSH levels). Household and occupational activity was not associated with lung cancer risk or biomarker levels.Entities:
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Year: 2010 PMID： 20050820 PMCID： PMC3696993 DOI： 10.3109/13547500903186452
Source DB: PubMed Journal: Biomarkers ISSN： 1354-750X Impact factor: 2.658