| Literature DB >> 20047977 |
Christine F Skibola1, Paige M Bracci, Alexandra Nieters, Angela Brooks-Wilson, Silvia de Sanjosé, Ann Maree Hughes, James R Cerhan, Danica R Skibola, Mark Purdue, Eleanor Kane, Qing Lan, Lenka Foretova, Maryjean Schenk, John J Spinelli, Susan L Slager, Anneclaire J De Roos, Martyn T Smith, Eve Roman, Wendy Cozen, Paolo Boffetta, Anne Kricker, Tongzhang Zheng, Tracy Lightfoot, Pierluigi Cocco, Yolanda Benavente, Yawei Zhang, Patricia Hartge, Martha S Linet, Nikolaus Becker, Paul Brennan, Luoping Zhang, Bruce Armstrong, Alex Smith, Renee Shiao, Anne J Novak, Marc Maynadie, Stephen J Chanock, Anthony Staines, Theodore R Holford, Elizabeth A Holly, Nathaniel Rothman, Sophia S Wang.
Abstract
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants were added to previous data (patients diagnosed from 1989 to 2005 in 14 case-control studies; 7,999 cases, 8,452 controls) for testing of polymorphisms in the TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A (rs1800890, rs1800896), and nucleotide-binding oligomerization domain containing 2 (NOD2) 3020insC (rs2066847) genes. Odds ratios were estimated for non-Hispanic whites and several ethnic subgroups using 2-sided tests. Consistent with previous findings, odds ratios were increased for "new" participant TNF -308A carriers (NHL: per-allele odds ratio (OR(allelic)) = 1.10, P(trend) = 0.001; diffuse large B-cell lymphoma (DLBCL): OR(allelic) = 1.23, P(trend) = 0.004). In the combined population, odds ratios were increased for TNF -308A carriers (NHL: OR(allelic) = 1.13, P(trend) = 0.0001; DLBCL: OR(allelic) = 1.25, P(trend) = 3.7 x 10(-6); marginal zone lymphoma: OR(allelic) = 1.35, P(trend) = 0.004) and LTA 252G carriers (DLBCL: OR(allelic) = 1.12, P(trend) = 0.006; mycosis fungoides: OR(allelic) = 1.44, P(trend) = 0.015). The LTA 252A>G/TNF -308G>A haplotype containing the LTA/TNF variant alleles was strongly associated with DLBCL (P = 2.9 x 10(-8)). Results suggested associations between IL10 -3575T>A and DLBCL (P(trend) = 0.02) and IL10 -1082A>G and mantle cell lymphoma (P(trend) = 0.04). These findings strengthen previous results for DLBCL and the LTA 252A>G/TNF -308A locus and provide robust evidence that these TNF/LTA gene variants, or others in linkage disequilibrium, are involved in NHL etiology.Entities:
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Year: 2010 PMID： 20047977 PMCID： PMC2842204 DOI： 10.1093/aje/kwp383
Source DB: PubMed Journal: Am J Epidemiol ISSN： 0002-9262 Impact factor: 4.897