Literature DB >> 20047818

Multidrug-resistant Acinetobacter baumannii: mechanisms of virulence and resistance.

Nicola C Gordon1, David W Wareham.   

Abstract

Infection due to Acinetobacter baumannii has become a significant challenge to modern healthcare systems. The organism shows a formidable capacity to develop antimicrobial resistance, yet the clinical impact of A. baumannii infection remains unclear. Much is known about the processes involved in multidrug resistance, but those underlying the pathogenicity and virulence potential of the organism are only beginning to be elucidated. In this article, we provide an overview of current knowledge, focusing on mechanisms of pathogenesis, the molecular basis of resistance and options for treatment in the absence of novel therapeutic agents. Copyright 2009 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

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Year:  2010        PMID： 20047818     DOI： 10.1016/j.ijantimicag.2009.10.024

Source DB:  PubMed          Journal:  Int J Antimicrob Agents        ISSN： 0924-8579            Impact factor:   5.283


  107 in total

1.  In vitro activity of telavancin in combination with colistin versus Gram-negative bacterial pathogens.

Authors:  Michael Hornsey; Christopher Longshaw; Lynette Phee; David W Wareham
Journal:  Antimicrob Agents Chemother       Date:  2012-04-09       Impact factor: 5.191

2.  Extremophilic Acinetobacter strains from high-altitude lakes in Argentinean Puna: remarkable UV-B resistance and efficient DNA damage repair.

Authors:  Virginia Helena Albarracín; Gopal P Pathak; Thierry Douki; Jean Cadet; Claudio Darío Borsarelli; Wolfgang Gärtner; María Eugenia Farias
Journal:  Orig Life Evol Biosph       Date:  2012-05-30       Impact factor: 1.950

3.  Host-microbe interactions that shape the pathogenesis of Acinetobacter baumannii infection.

Authors:  Brittany L Mortensen; Eric P Skaar
Journal:  Cell Microbiol       Date:  2012-06-14       Impact factor: 3.715

4.  ISAba825, a functional insertion sequence modulating genomic plasticity and bla(OXA-58) expression in Acinetobacter baumannii.

Authors:  Pablo Ravasi; Adriana S Limansky; Ramiro E Rodriguez; Alejandro M Viale; María A Mussi
Journal:  Antimicrob Agents Chemother       Date:  2010-11-22       Impact factor: 5.191

5.  NLRP3 inflammasome pathway has a critical role in the host immunity against clinically relevant Acinetobacter baumannii pulmonary infection.

Authors:  N Dikshit; S D Kale; H J Khameneh; V Balamuralidhar; C Y Tang; P Kumar; T P Lim; T T Tan; A L Kwa; A Mortellaro; B Sukumaran
Journal:  Mucosal Immunol       Date:  2017-06-14       Impact factor: 7.313

6.  Clinical characteristics and outcomes of bacteremia due to different genomic species of Acinetobacter baumannii complex in patients with solid tumors.

Authors:  M-C Chiang; S-C Kuo; S-J Chen; S-P Yang; Y-T Lee; T-L Chen; C-P Fung
Journal:  Infection       Date:  2011-09-02       Impact factor: 3.553

7.  Detection of VIM- and IMP-type Metallo-Beta-Lactamase Genes in Acinetobacter baumannii Isolates from Patients in Two Hospitals in Tehran.

Authors:  Saba Davoodi; Mohammad Ali Boroumand; Saeed Sepehriseresht; Leila Pourgholi
Journal:  Iran J Biotechnol       Date:  2015-03       Impact factor: 1.671

8.  Complete genome sequence and phylogenetic analysis of nosocomial pathogen Acinetobacter nosocomialis strain NCTC 8102.

Authors:  Bindu Subhadra; Surya Surendran; Bo Ra Lim; Jong-Sung Yim; Dong Ho Kim; Kyungho Woo; Kyudong Han; Man Hwan Oh; Chul Hee Choi
Journal:  Genes Genomics       Date:  2019-06-08       Impact factor: 1.839

9.  Resources for Genetic and Genomic Analysis of Emerging Pathogen Acinetobacter baumannii.

Authors:  Larry A Gallagher; Elizabeth Ramage; Eli J Weiss; Matthew Radey; Hillary S Hayden; Kiara G Held; Holly K Huse; Daniel V Zurawski; Mitchell J Brittnacher; Colin Manoil
Journal:  J Bacteriol       Date:  2015-04-06       Impact factor: 3.490

10.  Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii.

Authors:  Saito Higuchi; Yoshikuni Onodera; Megumi Chiba; Kazuki Hoshino; Naomasa Gotoh
Journal:  Antimicrob Agents Chemother       Date:  2013-02-04       Impact factor: 5.191
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