| Literature DB >> 20047277 |
Boulos Zacharie1, Shaun D Abbott, Jean-François Bienvenu, Alan D Cameron, Josée Cloutier, Jean-Simon Duceppe, Abdallah Ezzitouni, Daniel Fortin, Karine Houde, Caroline Lauzon, Nancie Moreau, Valérie Perron, Nicole Wilb, Michel Asselin, André Doucet, Marie-Eve Fafard, Dannyck Gaudreau, Brigitte Grouix, François Sarra-Bournet, Natalie St-Amant, Lyne Gagnon, Christopher L Penney.
Abstract
A first-in-class series of low molecular weight trisubstituted triazines were synthesized and evaluated for their ability to mimic protein A binding to human IgG antibody. The structure-activity relationship (SAR) demonstrates that the 1,3-phenylenediamine component was essential for robust activity. Twenty-two compounds, represented by lead molecule 34, displayed significant activity compared to protein A. These compounds may prove useful for the treatment of autoimmune disease.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20047277 DOI： 10.1021/jm901403r
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446