Literature DB >> 20046528

A case of pathologic splenic rupture as the initial manifestation of acute myeloid leukemia M2.

Ji-Sun Han1, Sung Yong Oh, Sung-Hyun Kim, Hyuk-Chan Kwon, Sook Hee Hong, Jin Yeong Han, Ki-Jae Park, Hyo-Jin Kim.   

Abstract

A pathologic splenic rupture refers to a rupture without trauma. A splenic rupture as the initial manifestation of acute myeloid leukemia is extremely rare. In this study, we described a rare case of acute myeloid leukemia presenting principally as an acute abdomen due to a pathologic splenic rupture in a 35-year old male patient. We can assert that a pathologic splenic rupture in hematologic diseases is a potentially life-threatening complication, which necessitates immediate operative intervention. Any such patient complaining about left upper abdominal tenderness should be closely observed, and further diagnostic investigations (ultrasonograph of the abdomen, abdominal CT scan) should be initiated in order to rule out a splenic rupture. The oncologist should be aware of this rare initial presentation of acute myeloid leukemia (AML) M2, as the condition generally necessitates a prompt splenectomy.

Entities:  

Keywords:  Acute myeloid leukemia M2; pathologic; splenic rupture

Mesh:

Year:  2009        PMID: 20046528      PMCID: PMC2799964          DOI: 10.3349/ymj.2010.51.1.138

Source DB:  PubMed          Journal:  Yonsei Med J        ISSN: 0513-5796            Impact factor:   2.759


  8 in total

1.  Splenic rupture in children with hematologic malignancies.

Authors:  U H Athale; S C Kaste; S M Bodner; R C Ribeiro
Journal:  Cancer       Date:  2000-01-15       Impact factor: 6.860

2.  Spontaneous splenic rupture in acute myeloid leukemia: sonographic follow-up study.

Authors:  C Görg; P Barth; R Weide; W B Schwerk
Journal:  Bildgebung       Date:  1994-03

3.  FLAG-IDA in the treatment of refractory/relapsed acute myeloid leukemia: single-center experience.

Authors:  D Pastore; G Specchia; P Carluccio; A Liso; A Mestice; R Rizzi; G Greco; C Buquicchio; V Liso
Journal:  Ann Hematol       Date:  2003-03-15       Impact factor: 3.673

4.  Acute myeloid leukemia presenting as splenic rupture.

Authors:  A Rajagopal; R Ramasamy; J Martin; P Kumar
Journal:  J Assoc Physicians India       Date:  2002-11

5.  Pathological splenic rupture: a rare complication of chronic myelomonocytic leukemia.

Authors:  Shannon Lynn Goddard; Alden E Chesney; Marciano D Reis; Zeina Ghorab; Mike Brzozowski; Frances C Wright; Richard A Wells
Journal:  Am J Hematol       Date:  2007-05       Impact factor: 10.047

Review 6.  Pathologic rupture of the spleen in hematologic malignancies: two additional cases.

Authors:  A A Giagounidis; M Burk; G Meckenstock; A J Koch; W Schneider
Journal:  Ann Hematol       Date:  1996-12       Impact factor: 3.673

7.  Pathologic rupture of the spleen as the initial manifestation in acute lymphoblastic leukemia.

Authors:  S Bernat; R García Boyero; M Guinot; F López; T Gozalbo; G Cañigral
Journal:  Haematologica       Date:  1998-08       Impact factor: 9.941

8.  Splenic rupture in acute megakaryoblastic leukemia.

Authors:  P Wong; K Takabayashi; Y Sugiura; T Asai; K Itoh; S Yoshida; H Horie
Journal:  Jpn J Med       Date:  1987-05
  8 in total
  3 in total

1.  Spontaneous splenic rupture in an acute leukemia patient with splenic tuberculosis: A case report.

Authors:  Yue Zhang; Juan Zhang; Tingting Chen; Hui Zeng; Bing Zhao; Yong Zhang; Xiaohuan Zhou; Wei Han; Yanping Hu; Fengge Liu; Zhijuan Shan; Weifeng Gao; Hebing Zhou
Journal:  Mol Clin Oncol       Date:  2016-12-28

2.  Spontaneous splenic rupture during induction chemotherapy for acute myeloid leukemia.

Authors:  Amer M Zeidan; Mhairi Mitchell; Rina Khatri; Doha Itani; Sosipatros Boikos; Sonali Bose; Pamela Lipsett; David Efron; Karen E King; Jonathan Gerber; Amy DeZern
Journal:  Leuk Lymphoma       Date:  2013-06-05

Review 3.  613 cases of splenic rupture without risk factors or previously diagnosed disease: a systematic review.

Authors:  F Kris Aubrey-Bassler; Nicholas Sowers
Journal:  BMC Emerg Med       Date:  2012-08-14
  3 in total

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