Literature DB >> 20045972

Development and application of a solution-phase automated synthesizer, 'ChemKonzert'.

Kazuhiro Machida1, Yoichiro Hirose, Shinichiro Fuse, Tohru Sugawara, Takashi Takahashi.   

Abstract

In this paper we describe the development of a fully-automated solution-phase synthesizer, 'ChemKonzert' that can be used to prepare a wide variety of organic compounds. The automated synthesizer is ingeniously designed to perform most of the chemical reactions currently used by synthetic organic chemists and utilizes a centrifugal separator to efficiently achieve liquid-liquid extraction. The design of the hardware and software will be described in this paper, and several examples of organic reactions will also be presented as applications of the apparatus.

Mesh：

Year:  2010        PMID： 20045972     DOI： 10.1248/cpb.58.87

Source DB:  PubMed          Journal:  Chem Pharm Bull (Tokyo)        ISSN： 0009-2363            Impact factor:   1.645


  10 in total

1.  HPLC-assisted automated oligosaccharide synthesis.

Authors:  N Vijaya Ganesh; Kohki Fujikawa; Yih Horng Tan; Keith J Stine; Alexei V Demchenko
Journal:  Org Lett       Date:  2012-05-30       Impact factor: 6.005

Review 2.  Automated Chemical Oligosaccharide Synthesis: Novel Approach to Traditional Challenges.

Authors:  Matteo Panza; Salvatore G Pistorio; Keith J Stine; Alexei V Demchenko
Journal:  Chem Rev       Date:  2018-06-28       Impact factor: 60.622

Review 3.  The Molecular Industrial Revolution: Automated Synthesis of Small Molecules.

Authors:  Melanie Trobe; Martin D Burke
Journal:  Angew Chem Int Ed Engl       Date:  2018-03-07       Impact factor: 15.336

4.  Manual and Automated Syntheses of the N-Linked Glycoprotein Core Glycans.

Authors:  Salvatore G Pistorio; Scott A Geringer; Keith J Stine; Alexei V Demchenko
Journal:  J Org Chem       Date:  2019-05-17       Impact factor: 4.354

5.  HPLC-Based Automated Synthesis of Glycans in Solution.

Authors:  Samira Escopy; Yashapal Singh; Keith J Stine; Alexei V Demchenko
Journal:  Chemistry       Date:  2022-05-25       Impact factor: 5.020

Review 6.  Synthesis and Glycosidation of Anomeric Halides: Evolution from Early Studies to Modern Methods of the 21st Century.

Authors:  Yashapal Singh; Scott A Geringer; Alexei V Demchenko
Journal:  Chem Rev       Date:  2022-06-08       Impact factor: 72.087

7.  HPLC-Assisted Automated Oligosaccharide Synthesis: Implementation of the Autosampler as a Mode of the Reagent Delivery.

Authors:  Salvatore G Pistorio; Swati S Nigudkar; Keith J Stine; Alexei V Demchenko
Journal:  J Org Chem       Date:  2016-09-14       Impact factor: 4.354

8.  Solution-phase automated synthesis of an α-amino aldehyde as a versatile intermediate.

Authors:  Hisashi Masui; Sae Yosugi; Shinichiro Fuse; Takashi Takahashi
Journal:  Beilstein J Org Chem       Date:  2017-01-17       Impact factor: 2.883

9.  Development of 2-arylbenzo[h]quinolone analogs as selective CYP1B1 inhibitors.

Authors:  Jinyun Dong; Zengtao Wang; Qingqing Meng; Qijing Zhang; Guang Huang; Jiahua Cui; Shaoshun Li
Journal:  RSC Adv       Date:  2018-04-20       Impact factor: 3.361

10.  Networking chemical robots for reaction multitasking.

Authors:  Dario Caramelli; Daniel Salley; Alon Henson; Gerardo Aragon Camarasa; Salah Sharabi; Graham Keenan; Leroy Cronin
Journal:  Nat Commun       Date:  2018-08-24       Impact factor: 14.919
  10 in total

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