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Literature DB >> 20038540

Lost in translation--basic science in the era of translational research.

Abstract

The concept of translational research, which aims to facilitate the application of basic scientific discoveries in clinical and community settings, is currently in vogue. While there are powerful forces driving this trend, support for translational research must be accompanied by a robust investment in basic science, which provides the essential raw material for translation and continues to represent humanity's best hope to meet a wide range of public health challenges.

Mesh：

Year: 2009 PMID： 20038540 PMCID： PMC2812192 DOI： 10.1128/IAI.01318-09

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

11 in total

1. Careers in translational clinical research-historical perspectives, future challenges.

Authors: David G Nathan
Journal: JAMA Date: 2002-05-08 Impact factor: 56.272

Review 2. Toll receptors: a central element in innate immune responses.

Authors: Thierry Vasselon; Patricia A Detmers
Journal: Infect Immun Date: 2002-03 Impact factor: 3.441

3. Roadmaps, translational research, and childish curiosity.

Authors: Gerald Weissmann
Journal: FASEB J Date: 2005-11 Impact factor: 5.191

4. The meaning of translational research and why it matters.

Authors: Steven H Woolf
Journal: JAMA Date: 2008-01-09 Impact factor: 56.272

5. Important science--it's all about the SPIN.

Authors: Arturo Casadevall; Ferric C Fang
Journal: Infect Immun Date: 2009-07-27 Impact factor: 3.441

6. Basic research (I)

Authors: D E Koshland
Journal: Science Date: 1993-01-15 Impact factor: 47.728

7. Translational careers.

Authors: N Andrews; J E Burris; T R Cech; B S Coller; W F Crowley; E K Gallin; K L Kelner; D G Kirch; A I Leshner; C D Morris; F T Nguyen; J Oates; N S Sung
Journal: Science Date: 2009-05-15 Impact factor: 47.728

Review 8. Renaissance for mouse models of human hematopoiesis and immunobiology.

Authors: Markus G Manz; James P Di Santo
Journal: Nat Immunol Date: 2009-10 Impact factor: 25.606

9. Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1.

Authors: Kristina Dach; Josip Zovko; Michael Hogardt; Isabel Koch; Katrin van Erp; Jürgen Heesemann; Reinhard Hoffmann
Journal: Infect Immun Date: 2009-09-28 Impact factor: 3.441

10. A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen.

Authors: Jon Oscherwitz; Fen Yu; Kemp B Cease
Journal: Infect Immun Date: 2009-10-05 Impact factor: 3.441

32 in total

Lost in translation--basic science in the era of translational research.

1. Careers in translational clinical research-historical perspectives, future challenges.

Review 2. Toll receptors: a central element in innate immune responses.

3. Roadmaps, translational research, and childish curiosity.

4. The meaning of translational research and why it matters.

5. Important science--it's all about the SPIN.

6. Basic research (I)

7. Translational careers.

Review 8. Renaissance for mouse models of human hematopoiesis and immunobiology.

9. Bacterial toxins induce sustained mRNA expression of the silencing transcription factor klf2 via inactivation of RhoA and Rhophilin 1.

10. A heterologous helper T-cell epitope enhances the immunogenicity of a multiple-antigenic-peptide vaccine targeting the cryptic loop-neutralizing determinant of Bacillus anthracis protective antigen.

1. Intervention, integration and translation in obesity research: Genetic, developmental and metaorganismal approaches.

2. Reforming science: structural reforms.

3. (A)Historical science.

4. Retracted science and the retraction index.

5. A Guide to Time Lag and Time Lag Shortening Strategies in Oncology-Based Drug Development.

Review 6. Categorizing biomedical research: the basics of translation.

7. Clinical and translational research and community engagement: implications for researcher capacity building.

8. On the training of future neuroscientists: insights from the Grass laboratory.

9. A CURE Biochemistry Laboratory Module to Study Protein-Protein Interactions by NMR Spectroscopy.

Review 10. A road map to Translational Medicine in Qatar and a model for the world.