Literature DB >> 20037801

Phytochemical analysis of an antiviral fraction of Radix astragali using HPLC-DAD-ESI-MS/MS.

Li Tang1, Ying Liu, Yeling Wang, Chunlin Long.   

Abstract

Radix astragali (Huangqi in Chinese) is a well-known traditional Chinese medicinal herb that has been used clinically in China for centuries to cure various diseases. To profile the antiviral constituents of this herb, a high-performance liquid chromatography-diode array detector-electrospray ionization-tandem mass spectrometry (HPLC-DAD-ESI-MS/MS) analytical method was developed to separate and determinate the active part of the extract of Radix astragali, which showed potent inhibition of several viruses. By comparing their retention time and MS data with those obtained from the authentic compounds and the published data, a total of 18 compounds, comprising 11 flavonoids and 7 saponins, were identified. This study provides an approach to rapidly characterize bioactive constituents in traditional Chinese medicines (TCMs).

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20037801     DOI： 10.1007/s11418-009-0381-1

Source DB:  PubMed          Journal:  J Nat Med        ISSN： 1340-3443            Impact factor:   2.343


  12 in total

1.  Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus.

Authors:  L Z Lin; X G He; M Lindenmaier; G Nolan; J Yang; M Cleary; S X Qiu; G A Cordell
Journal:  J Chromatogr A       Date:  2000-04-21       Impact factor: 4.759

2.  Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection.

Authors:  H B Xiao; M Krucker; K Albert; X M Liang
Journal:  J Chromatogr A       Date:  2004-04-02       Impact factor: 4.759

3.  Simultaneous determination of 15 marker constituents in various radix Astragali preparations by solid-phase extraction and high-performance liquid chromatography.

Authors:  Lian-Wen Qi; Qing-Tao Yu; Ling Yi; Mei-Ting Ren; Xiao-Dong Wen; Yu-Xia Wang; Ping Li
Journal:  J Sep Sci       Date:  2008-01       Impact factor: 3.645

4.  Qualitative and quantitative analysis of Radix Astragali products by fast high-performance liquid chromatography-diode array detection coupled with time-of-flight mass spectrometry through dynamic adjustment of fragmentor voltage.

Authors:  Lian-Wen Qi; Jun Cao; Ping Li; Qing-Tao Yu; Xiao-Dong Wen; Yu-Xia Wang; Chang-Yin Li; Kang-De Bao; Xiao-Xiao Ge; Xiao-Lan Cheng
Journal:  J Chromatogr A       Date:  2008-07-12       Impact factor: 4.759

5.  LC-MS characterization of efficacy substances in serum of experimental animals treated with Sophora flavescens extracts.

Authors:  Guan Ye; Hai-Yan Zhu; Zhi-Xiong Li; Chun-Hui Ma; Ming-Song Fan; Zhao-Lin Sun; Cheng-Gang Huang
Journal:  Biomed Chromatogr       Date:  2007-06       Impact factor: 1.902

6.  Cycloartane triterpene glycosides from the hairy root cultures of Astragalus membranaceus.

Authors:  M Hirotani; Y Zhou; H Rui; T Furuya
Journal:  Phytochemistry       Date:  1994-11       Impact factor: 4.072

7.  Simultaneous characterization of isoflavonoids and astragalosides in two Astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry.

Authors:  Xi Zhang; Hong-Bin Xiao; Xing-Ya Xue; Yan-Guo Sun; Xin-Miao Liang
Journal:  J Sep Sci       Date:  2007-08       Impact factor: 3.645

8.  In vivo and in vitro antiviral activities of calycosin-7-O-beta-D-glucopyranoside against coxsackie virus B3.

Authors:  Haiyan Zhu; Yuanyuan Zhang; Guan Ye; Zhixiong Li; Pei Zhou; Chenggang Huang
Journal:  Biol Pharm Bull       Date:  2009-01       Impact factor: 2.233

9.  Rapid and sensitive screening and characterization of phenolic acids, phthalides, saponins and isoflavonoids in Danggui Buxue Tang by rapid resolution liquid chromatography/diode-array detection coupled with time-of-flight mass spectrometry.

Authors:  Lian-Wen Qi; Xiao-Dong Wen; Jun Cao; Chang-Yin Li; Ping Li; Ling Yi; Yu-Xia Wang; Xiao-Lan Cheng; Xiao-Xiao Ge
Journal:  Rapid Commun Mass Spectrom       Date:  2008-08       Impact factor: 2.419

10.  Determination and quantification of astragalosides in Radix Astragali and its medicinal products using LC-MS.

Authors:  Yuangang Zu; Mingming Yan; Yujie Fu; Wei Liu; Lin Zhang; Chengbo Gu; Thomas Efferth
Journal:  J Sep Sci       Date:  2009-02       Impact factor: 3.645
View more
  6 in total

1.  Astragaloside content in the periderm, cortex, and xylem of Astragalus membranaceus root.

Authors:  Ha-Jeong Kwon; Jeehyun Hwang; Sun-Kyoung Lee; Yong-Duk Park
Journal:  J Nat Med       Date:  2013-02-05       Impact factor: 2.343

2.  Clinical characteristics and risk factors for peripartum cardiomyopathy.

Authors:  G Y Huang; L Y Zhang; M A Long-Le; Le-Xin Wang
Journal:  Afr Health Sci       Date:  2012-03       Impact factor: 0.927

3.  Astragalus saponins affect proliferation, invasion and apoptosis of gastric cancer BGC-823 cells.

Authors:  Tao Wang; Xiaoyan Xuan; Min Li; Ping Gao; Yuling Zheng; Wenqiao Zang; Guoqiang Zhao
Journal:  Diagn Pathol       Date:  2013-10-24       Impact factor: 2.644

4.  Intraspecific and heteroplasmic variations, gene losses and inversions in the chloroplast genome of Astragalus membranaceus.

Authors:  Wanjun Lei; Dapeng Ni; Yujun Wang; Junjie Shao; Xincun Wang; Dan Yang; Jinsheng Wang; Haimei Chen; Chang Liu
Journal:  Sci Rep       Date:  2016-02-22       Impact factor: 4.379

5.  Full-length transcriptome sequences by a combination of sequencing platforms applied to isoflavonoid and triterpenoid saponin biosynthesis of Astragalus mongholicus Bunge.

Authors:  Minzhen Yin; Shanshan Chu; Tingyu Shan; Liangping Zha; Huasheng Peng
Journal:  Plant Methods       Date:  2021-06-15       Impact factor: 4.993

6.  Comparative analysis of twenty-five compounds in different parts of Astragalus membranaceus var. mongholicus and Astragalus membranaceus by UPLC-MS/MS.

Authors:  Yuan Li; Sheng Guo; Yue Zhu; Hui Yan; Da-Wei Qian; Han-Qing Wang; Jian-Qiang Yu; Jin-Ao Duan
Journal:  J Pharm Anal       Date:  2019-06-25
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.