| Literature DB >> 17370298 |
Guan Ye1, Hai-Yan Zhu, Zhi-Xiong Li, Chun-Hui Ma, Ming-Song Fan, Zhao-Lin Sun, Cheng-Gang Huang.
Abstract
Anti-DHBV (duck hepatitis B virus) activity was found in the aqueous extracts of Sophora flavescens Ait. in vivo. Liquid chromatography/electrospray ionization ion trap mass spectrometry was applied to characterize the components in duck serum after oral administration of S. flavescens extract. Oxymatrine (1), sophoranol (2), sophoridine (3) and matrine (4) were identified in the serum. Further research on the four compounds was evaluated for their antiviral activity against HBV (hepatitis B virus) in cell culture. The results suggested that oxymatrine, sophoranol and matrine were the efficacy substances for anti-HBV activity in aqueous extracts of S. flavescens Ait. Copyright 2007 John Wiley & Sons, Ltd.Entities:
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Year: 2007 PMID： 17370298 DOI： 10.1002/bmc.805
Source DB: PubMed Journal: Biomed Chromatogr ISSN： 0269-3879 Impact factor: 1.902