OBJECTIVE: To assess the expression of β-catenin in benign and malignant salivary gland tumors and to investigate the possible role of β-catenin in the behavior of salivary gland tumors. STUDY DESIGN: Paraffin embedded tissues from 45 salivary gland tumors were studied immunohistochemically for expression of β-catenin. RESULT: Reduced/aberrant β-catenin expression was seen in benign and malignant salivary gland tumors. Cytoplasmic localization and reduced membranous expression were comparatively observed more in malignant salivary gland tumors. Additionally, in pleomorphic adenomas (PAs), β-catenin exhibited intense staining in cells arranged in the form of ducts/tubules, whereas cells in clusters and sheets showed weaker immunoreactivity. CONCLUSION: Reduced and cytoplasmic localization of β-catenin could indicate lack of differentiation, invasive potential, and aggressive behavior in malignant salivary gland tumors. Furthermore, change in expression based on the arrangement of tumor cells may suggest that β-catenin may have a role in morphological variations seen in PAs.
OBJECTIVE: To assess the expression of β-catenin in benign and malignant salivary gland tumors and to investigate the possible role of β-catenin in the behavior of salivary gland tumors. STUDY DESIGN:Paraffin embedded tissues from 45 salivary gland tumors were studied immunohistochemically for expression of β-catenin. RESULT: Reduced/aberrant β-catenin expression was seen in benign and malignant salivary gland tumors. Cytoplasmic localization and reduced membranous expression were comparatively observed more in malignant salivary gland tumors. Additionally, in pleomorphic adenomas (PAs), β-catenin exhibited intense staining in cells arranged in the form of ducts/tubules, whereas cells in clusters and sheets showed weaker immunoreactivity. CONCLUSION: Reduced and cytoplasmic localization of β-catenin could indicate lack of differentiation, invasive potential, and aggressive behavior in malignant salivary gland tumors. Furthermore, change in expression based on the arrangement of tumor cells may suggest that β-catenin may have a role in morphological variations seen in PAs.
Authors: Karla Flaviana Carneiro Castelo Branco; Andre Luis Ribeiro Ribeiro; Raíssa Pinheiro de Mendonça; João de Jesus Viana Pinheiro; Maria Sueli da Silva Kataoka; Maria Vanda Catão Arnaud; Sérgio de Melo Alves Junior Journal: Eur Arch Otorhinolaryngol Date: 2018-10-26 Impact factor: 2.503
Authors: J P Alameda; M J Fernández-Aceñero; R Moreno-Maldonado; M Navarro; R Quintana; A Page; A Ramírez; A Bravo; M L Casanova Journal: Cell Death Dis Date: 2011-09-08 Impact factor: 8.469
Authors: Maria M Szwarc; Ramakrishna Kommagani; Mary C Peavey; Lan Hai; David M Lonard; John P Lydon Journal: PLoS One Date: 2017-03-02 Impact factor: 3.240
Authors: Pawel Sowa; Karolina Goroszkiewicz; Joanna Szydelko; Joanna Chechlinska; Katarzyna Pluta; Wojciech Domka; Maciej Misiolek; Wojciech Scierski Journal: Biomed Res Int Date: 2018-08-01 Impact factor: 3.411
Authors: Susan Park; Manali Vora; Annemieke van Zante; Joseph Humtsoe; Hyun-Su Kim; Sue Yom; Shweta Agarwal; Patrick Ha Journal: J Otolaryngol Head Neck Surg Date: 2020-07-10