PURPOSE: Extent of involvement and activity of ulcerative colitis (UC) is best evaluated by colonoscopy. Colonoscopy however carries risk during acute exacerbation. We investigated the utility of PET/CT colonography for assessment of extent and activity of UC. METHODS: Within a 1-week window, 15 patients with mild to moderately active UC underwent colonoscopy and PET/CT colonography 60 min after injection of 10 mCi of (18)F-fluorodeoxyglucose (FDG). PET activity score based on the amount of FDG uptake and endoscopic mucosal activity in seven colonic segments of each patient was recorded. The mean maximum standardized uptake value (SUV(max)) of seven segments was compared with activity in liver. A PET activity grade of 0, 1, 2 or 3 was assigned to each region depending upon their SUV(max) ratio (colon segment to liver). RESULTS: The extent of disease was left-sided colitis in five and pancolitis in ten. The mean Ulcerative Colitis Disease Activity Index (UCDAI) was 7.6. The number of segments involved as per colonoscopic evaluation and PET/CT colonography was 67 and 66, respectively. There was a good correlation for extent evaluation between the two modalities (kappa 55.3%, p = 0.02). One patient had grade 0 PET activity, nine had grade 2 and five had grade 3 PET activity. In six patients, there was one to one correlation between PET activity grades with that of endoscopic grade. One patient showed activity in the sacroiliac joint suggesting active sacroiliitis. CONCLUSION: PET/CT colonography is a novel non-invasive technique for the assessment of extent and activity of the disease in patients with UC.
PURPOSE: Extent of involvement and activity of ulcerative colitis (UC) is best evaluated by colonoscopy. Colonoscopy however carries risk during acute exacerbation. We investigated the utility of PET/CT colonography for assessment of extent and activity of UC. METHODS: Within a 1-week window, 15 patients with mild to moderately active UC underwent colonoscopy and PET/CT colonography 60 min after injection of 10 mCi of (18)F-fluorodeoxyglucose (FDG). PET activity score based on the amount of FDG uptake and endoscopic mucosal activity in seven colonic segments of each patient was recorded. The mean maximum standardized uptake value (SUV(max)) of seven segments was compared with activity in liver. A PET activity grade of 0, 1, 2 or 3 was assigned to each region depending upon their SUV(max) ratio (colon segment to liver). RESULTS: The extent of disease was left-sided colitis in five and pancolitis in ten. The mean Ulcerative Colitis Disease Activity Index (UCDAI) was 7.6. The number of segments involved as per colonoscopic evaluation and PET/CT colonography was 67 and 66, respectively. There was a good correlation for extent evaluation between the two modalities (kappa 55.3%, p = 0.02). One patient had grade 0 PET activity, nine had grade 2 and five had grade 3 PET activity. In six patients, there was one to one correlation between PET activity grades with that of endoscopic grade. One patient showed activity in the sacroiliac joint suggesting active sacroiliitis. CONCLUSION: PET/CT colonography is a novel non-invasive technique for the assessment of extent and activity of the disease in patients with UC.
Authors: R A Hawkins; C Hoh; J Glaspy; Y Choi; M Dahlbom; S Rege; C Messa; E Nietszche; E Hoffman; L Seeger Journal: Semin Nucl Med Date: 1992-10 Impact factor: 4.446
Authors: Mark S Silverberg; Jack Satsangi; Tariq Ahmad; Ian D R Arnott; Charles N Bernstein; Steven R Brant; Renzo Caprilli; Jean-Frédéric Colombel; Christoph Gasche; Karel Geboes; Derek P Jewell; Amir Karban; Edward V Loftus; A Salvador Peña; Robert H Riddell; David B Sachar; Stefan Schreiber; A Hillary Steinhart; Stephan R Targan; Severine Vermeire; B F Warren Journal: Can J Gastroenterol Date: 2005-09 Impact factor: 3.522
Authors: Marc J Gollub; Tim Akhurst; Arnold J Markowitz; Martin R Weiser; José G Guillem; Lachlan McG Smith; Steven M Larson; Alexander R Margulis Journal: AJR Am J Roentgenol Date: 2007-01 Impact factor: 3.959
Authors: M F Neurath; D Vehling; K Schunk; M Holtmann; H Brockmann; A Helisch; T Orth; M Schreckenberger; P R Galle; P Bartenstein Journal: Am J Gastroenterol Date: 2002-08 Impact factor: 10.864
Authors: Lode Goethals; Sofie Wilgenhof; Frank De Geeter; Hendrik Everaert; Bart Neyns Journal: Eur J Nucl Med Mol Imaging Date: 2011-03-02 Impact factor: 9.236
Authors: Yan Li; Karsten Beiderwellen; Felix Nensa; Johannes Grüneisen; Gustav Dobos; Ken Herrmann; Thomas Lauenstein; Lale Umutlu; Jost Langhorst Journal: Eur J Nucl Med Mol Imaging Date: 2018-02-17 Impact factor: 9.236
Authors: Yan Li; Michael Khamou; Benedikt Michael Schaarschmidt; Lale Umutlu; Michael Forsting; Aydin Demircioglu; Johannes Haubold; Anna Katharina Koch; Nils-Martin Bruckmann; Lino Morris Sawicki; Ken Herrmann; James Hunter Boone; Jost Langhorst Journal: Br J Radiol Date: 2020-06-24 Impact factor: 3.039
Authors: Andor W J M Glaudemans; Erik F J de Vries; Filippo Galli; Rudi A J O Dierckx; Riemer H J A Slart; Alberto Signore Journal: Clin Dev Immunol Date: 2013-08-21